{ "id": 6195, "label": "laryngeal disorder", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0004382", "properties": { "xrefs": [ "DOID:786", "EFO:0009673", "ICD9:478.70", "MEDGEN:7268", "MESH:D007818", "NCIT:C26810", "SCTID:60600009", "UMLS:C0023051" ], "synonyms": [ "disease of larynx", "disease or disorder of larynx", "disorder of larynx", "disorder of the larynx", "laryngeal disease", "laryngeal disorder", "larynx disease", "larynx disease or disorder" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma." }, "isLeaf": false, "isRoot": false, "child_count": 20, "parents": [ { "id": 6623, "label": "upper respiratory tract disorder", "isLeaf": false, "isRoot": false, "parents": [ 6815 ], "type_id": 0, "properties": { "xrefs": [ "DOID:974", "ICD9:478.1", "ICD9:478.19", "ICD9:478.9", "MEDGEN:538406", "SCTID:201060008", "UMLS:C0264221" ], "synonyms": [ "disease of upper respiratory tract", "disease or disorder of upper respiratory tract", "disorder of upper respiratory tract", "upper respiratory tract disease", "upper respiratory tract disease or disorder" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A disease involving the upper respiratory tract." }, "child_count": 10, "reference_id": "MONDO:0004867" } ], "children": [ { "id": 2943, "label": "spasmodic dystonia", "isLeaf": true, "isRoot": false, "parents": [ 2936, 6195 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050844", "GARD:0027260", "ICD9:478.79", "MEDGEN:409603", "MESH:D055154", "Orphanet:93961", "SCTID:3331000119108", "UMLS:C1963946" ], "synonyms": [ "laryngeal dyskinesia", "laryngeal dystonia", "spasmodic dysphonia", "spastic dysphonia", "abductor spasmodic dysphonia", "adductor spasmodic dysphonia", "mixed spasmodic dysphonia (type)" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A chronic voice disorder characterized by momentary periods of uncontrolled spasms of the muscles of the larynx." }, "child_count": 0, "reference_id": "MONDO:0000485" }, { "id": 3538, "label": "laryngostenosis", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11527", "HP:0001602", "ICD10CM:J38.6", "ICD9:478.74", "MEDGEN:7274", "MESH:D007829", "SCTID:75547007", "UMLS:C0023075", "icd11.foundation:803766116" ], "synonyms": [ "stenosis of larynx" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Narrowing of the laryngeal airway." }, "child_count": 0, "reference_id": "MONDO:0001305" }, { "id": 4698, "label": "laryngitis", "isLeaf": false, "isRoot": false, "parents": [ 6195, 20399 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3437", "ICD9:464.00", "MEDGEN:7273", "MESH:D007827", "NCIT:C26811", "SCTID:45913009", "UMLS:C0023067" ], "synonyms": [ "inflammation of larynx", "laryngeal Inflammation", "laryngeal inflammation", "larynx inflammation" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "An acute or chronic, bacterial or viral inflammatory process affecting the larynx. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness." }, "child_count": 8, "reference_id": "MONDO:0002647" }, { "id": 9212, "label": "laryngeal abductor paralysis", "isLeaf": true, "isRoot": false, "parents": [ 6195, 21538 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0005509", "ICD9:748.3", "MEDGEN:96004", "OMIM:150260", "Orphanet:2808", "SCTID:232442001", "UMLS:C0396059", "icd11.foundation:965049946" ], "synonyms": [ "Gerhardt syndrome", "familial vocal cord dysfunction", "laryngeal abductor paralysis", "Labd", "vocal cord dysfunction familial", "vocal cord dysfunction, familial" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ] }, "child_count": 0, "reference_id": "MONDO:0007876" }, { "id": 9214, "label": "congenital laryngomalacia", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080833", "GARD:0006865", "ICD10CM:Q31.5", "ICD9:748.3", "MEDGEN:120500", "MESH:D055092", "MedDRA:10060786", "NCIT:C98971", "OMIM:150280", "Orphanet:2373", "SCTID:253737007", "UMLS:C0264303", "icd11.foundation:64182721" ], "synonyms": [ "congenital laryngeal stridor", "laryngomalacia", "laryngomalacia congenital" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Increased collapsibility of the larynx." }, "child_count": 0, "reference_id": "MONDO:0007878" }, { "id": 9215, "label": "larynx atresia", "isLeaf": true, "isRoot": false, "parents": [ 6195, 21538 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0003194", "ICD9:748.3", "MEDGEN:78572", "MESH:C563637", "NANDO:2200190", "NCIT:C98972", "OMIM:150300", "Orphanet:1202", "SCTID:64981002", "UMLS:C0265756" ], "synonyms": [ "congenital atresia of larynx", "congenital atresia of the larynx", "laryngeal atresia", "congenital partial atresia of the larynx", "larynx, congenital partial atresia OF" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A congenital malformation of the larynx in which there is failure of recanalization of the laryngotracheal tube during gestation." }, "child_count": 0, "reference_id": "MONDO:0007879" }, { "id": 9216, "label": "congenital laryngeal web", "isLeaf": true, "isRoot": false, "parents": [ 4370, 6195 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0016596", "MEDGEN:372058", "MESH:C537676", "MESH:C563636", "MedDRA:10023871", "NCIT:C98970", "OMIM:150360", "Orphanet:2374", "SCTID:444921008", "UMLS:C1835494", "icd11.foundation:1641764672" ], "synonyms": [ "Laryngeal web", "gay Feinmesser Cohen syndrome", "glottic web, congenital anterior", "laryngeal web, congenital heart disease and low stature", "laryngeal web, familial", "subglottic Bar", "subglottic bar, congenital heart disease and low stature", "subglottic web" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Congenital laryngeal web is a rare malformation consisting of a membrane-like structure that extends across the laryngeal lumen close to the level of the vocal cords." }, "child_count": 0, "reference_id": "MONDO:0007880" }, { "id": 12393, "label": "H syndrome", "isLeaf": true, "isRoot": false, "parents": [ 6195, 7931, 19140, 23867 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111278", "GARD:0010239", "MEDGEN:400532", "MESH:C535391", "MESH:C538322", "NANDO:2200457", "OMIM:602782", "Orphanet:168569", "SCTID:711159002", "UMLS:C1864445", "icd11.foundation:107155297" ], "synonyms": [ "Asrar Facharzt Haque syndrome", "H syndrome", "Faisalabad histiocytosis", "HJCD", "Rosai-Dorfman disease, familial", "SLC29A3 spectrum disorder", "histiocytosis and lymphadenopathy with or without cutaneous, Cardiac, and/or endocrine features, Joint contractures, and/or deafness", "histiocytosis with Joint contractures and sensorineural deafness", "histiocytosis-lymphadenopathy plus syndrome", "hyperpigmentation, cutaneous, with hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism with or without hearing loss", "pigmented hypertrichosis with insulin-dependent diabetes mellitus", "sinus histiocytosis and massive lymphadenopathy" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A systemic inherited histiocytosis, with characteristic cutaneous findings accompanying systemic manifestations. H syndrome refers to the major clinical findings of hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, and occasionally, hyperglycemia/diabetes mellitus. Due to overlapping clinical features, H syndrome is now considered to include pigmented hypertrichosis with insulin dependent diabetes mellitus syndrome (PHID), Faisalabad histiocytosis (FHC) and familial sinus histiocytosis with massive lymphadenopathy (FSHML)." }, "child_count": 0, "reference_id": "MONDO:0011273" }, { "id": 16191, "label": "primary laryngeal lymphangioma", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0019891", "MEDGEN:1634144", "Orphanet:137926", "SCTID:763617006", "UMLS:C4706521" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Primary laryngeal lymphangioma is a rare, benign, congenital malformation of the lymphatic system characterized by a polypoidal, variable-sized, soft tissue mass located in the larynx. Most lesions manifest by the 2nd year of life and, depending on the size, patients may present with changes in voice, dysphagia, stridor, airway obstruction and/or respiratory distress. Cystic hygroma of the neck is frequently associated." }, "child_count": 0, "reference_id": "MONDO:0015314" }, { "id": 16193, "label": "congenital laryngeal palsy", "isLeaf": true, "isRoot": false, "parents": [ 4427, 6195 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0012713", "MEDGEN:96003", "Orphanet:137932", "UMLS:C0396058", "icd11.foundation:1508780420" ], "synonyms": [ "congenital vocal cord paralysis" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Congenital laryngeal palsy is a rare larynx anomaly characterized by unilateral or bilateral paralysis of the vocal cords as a result of dysfunction of the motor nerve supply to the larynx. Patients typically present at birth (or shortly thereafter) with stridor, weak or breathy cry, dysphonia or aphonia, feeding or aspiration difficulties and, occasionally, respiratory compromise. Neurological disease, masses that cause compression and aberrant vessels are often associated. Most cases resolve spontaneously over 6-12 months." }, "child_count": 0, "reference_id": "MONDO:0015316" }, { "id": 16248, "label": "congenital subglottic stenosis", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0019952", "ICD10CM:Q31.1", "ICD9:748.3", "MEDGEN:97973", "NANDO:1201004", "NANDO:2200190", "Orphanet:141121", "SCTID:204552001", "UMLS:C0396051", "icd11.foundation:76585642" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0015395" }, { "id": 16249, "label": "congenital laryngeal cyst", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0019953", "MEDGEN:451040", "Orphanet:141124", "SCTID:765763007", "UMLS:C0339880", "icd11.foundation:591042640" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Congenital laryngeal cyst is a rare larynx anomaly characterized by a cyst involving the larynx or supraglottis locations, such as the epiglottis and vallecula. Timing and severity of presentation depend on the size of the cyst and its proximity to the glottis and range from severe prenatal airway obstruction leading to polyhydramnios and pulmonary hypoplasia to postnatal inspiratory stridor associated with muffled cry, hoarseness and cyanotic episodes, and to feeding difficulties and failure to thrive. It can be associated with laryngomalacia." }, "child_count": 0, "reference_id": "MONDO:0015396" }, { "id": 17027, "label": "laryngocele", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0003191", "ICD10CM:Q31.3", "ICD9:748.3", "MEDGEN:452345", "MESH:D059608", "MedDRA:10023885", "NCIT:C97062", "Orphanet:2372", "SCTID:51523009", "UMLS:C0265761", "icd11.foundation:360056769" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A rare congenital malformation in the larynx. It is characterized by the presence of an air-filled sac within the laryngeal wall which may bulge on the neck." }, "child_count": 0, "reference_id": "MONDO:0016530" }, { "id": 20241, "label": "laryngeal diphtheria", "isLeaf": true, "isRoot": false, "parents": [ 6195, 7160, 21378 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025266", "ICD10CM:A36.2", "ICD9:032.3", "MEDGEN:4336", "NCIT:C34546", "SCTID:50215002", "UMLS:C0012557", "icd11.foundation:1101542926" ], "synonyms": [ "laryngeal diphtheria", "Diphtheritic laryngotracheitis", "Laryngeal Diphtheria", "Laryngeal diphtheria", "diphtheritic laryngotracheitis" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Infection of the larynx by Corynebacterium diphtheriae." }, "child_count": 0, "reference_id": "MONDO:0020863" }, { "id": 20251, "label": "laryngeal granuloma", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "ICD9:478.79", "MEDGEN:6674", "MESH:D006102", "SCTID:72211003", "UMLS:C0018196" ], "synonyms": [ "laryngeal granuloma", "Granuloma of Larynx", "Granuloma, Laryngeal", "Granulomas, Laryngeal", "Laryngeal Granuloma", "Laryngeal Granulomas", "Laryngeal granuloma", "Larynx Granuloma", "Larynx Granulomas" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A tumor-like nodule or mass of inflammatory granulation tissue projecting into the lumen of the LARYNX." }, "child_count": 0, "reference_id": "MONDO:0020974" }, { "id": 20312, "label": "laryngeal neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6195, 20056 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0003817", "MEDGEN:7271", "MESH:D007822", "NCIT:C3156", "SCTID:126692004", "UMLS:C0023055" ], "synonyms": [ "laryngeal neoplasm", "laryngeal tumor", "laryngeal tumour", "larynx neoplasm", "larynx neoplasm (disease)", "larynx tumor", "larynx tumour", "neoplasm of larynx", "neoplasm of the larynx", "tumor of larynx", "tumor of the larynx", "tumour of larynx", "tumour of the larynx" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A benign or malignant neoplasm involving the larynx." }, "child_count": 12, "reference_id": "MONDO:0021071" }, { "id": 20557, "label": "polyp of vocal cord", "isLeaf": true, "isRoot": false, "parents": [ 6195, 6807 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0009478", "MEDGEN:21887", "NCIT:C3440", "SCTID:9078005", "UMLS:C0042929", "icd11.foundation:1351291002" ], "synonyms": [ "laryngeal vocal fold polyp", "polyp of the vocal cord", "vocal cord polyp" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A non-neoplastic polypoid swelling of the vocal cord mucosa. It is usually unilateral and caused by excessive use of the voice." }, "child_count": 0, "reference_id": "MONDO:0021420" }, { "id": 23254, "label": "voice disorders", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0009692", "MEDGEN:12120", "MESH:D014832", "NCIT:C3441", "SCTID:71941009", "UMLS:C0042940" ], "synonyms": [ "neurologic voice disorder", "voice disorder", "neurologic dysphonia" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A pathologic process in the larynx that affects the production of speech. Causes include vocal cord paresis, vocal cord nodule, vocal cord polyp, and laryngitis." }, "child_count": 0, "reference_id": "MONDO:0043862" }, { "id": 25195, "label": "acquired laryngomalacia", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080834", "MEDGEN:1762305", "UMLS:C5437619", "icd11.foundation:1224426540" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A laryngeal disease that is characterized by acquired collapse of laryngeal suprastructures." }, "child_count": 0, "reference_id": "MONDO:0850295" }, { "id": 25821, "label": "idiopathic subglottic stenosis", "isLeaf": true, "isRoot": false, "parents": [ 6195 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0026930", "MEDGEN:1864137", "Orphanet:652681", "UMLS:C5925119" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0958099" } ], "roots": [ { "id": 6623, "label": "upper respiratory tract disorder" } ] }