{
  "id": 6233,
  "label": "hyperthyroidism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004425",
  "properties": {
    "xrefs": [
      "DOID:7998",
      "EFO:0009189",
      "ICD9:242.90",
      "MEDGEN:6972",
      "MESH:D006980",
      "NANDO:2100119",
      "NANDO:2200329",
      "NCIT:C3123",
      "SCTID:34486009",
      "UMLS:C0020550"
    ],
    "synonyms": [
      "overactive thyroid"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 5187,
      "label": "thyroid gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:50",
          "EFO:1000627",
          "ICD10CM:E00-E07",
          "ICD9:240-246",
          "ICD9:246.8",
          "ICD9:246.9",
          "MEDGEN:1378579",
          "MESH:D013959",
          "NCIT:C26893",
          "SCTID:14304000",
          "UMLS:C4317107",
          "Wikipedia:Thyroid_disease"
        ],
        "synonyms": [
          "disease of thyroid gland",
          "disease or disorder of thyroid gland",
          "disorder of thyroid gland",
          "thyroid disease",
          "thyroid gland disease",
          "thyroid gland disease or disorder",
          "thyroid gland diseases",
          "thyroid gland disorder",
          "thyroid gland disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the thyroid gland."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003240"
    }
  ],
  "children": [
    {
      "id": 3354,
      "label": "toxic diffuse goiter",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6233,
        7075
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10719",
          "ICD10CM:E05.0",
          "ICD9:242.00",
          "MEDGEN:488851",
          "SCTID:267374005",
          "UMLS:C0342122"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0001104"
    },
    {
      "id": 8419,
      "label": "thyroid crisis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12837",
          "EFO:1001212",
          "HP:0011782",
          "ICD9:242.81",
          "ICD9:242.91",
          "MEDGEN:11813",
          "MESH:D013958",
          "MedDRA:10043705",
          "NCIT:C112836",
          "SCTID:29028009",
          "UMLS:C0040127",
          "icd11.foundation:1215823328"
        ],
        "synonyms": [
          "thyroid crisis",
          "thyroid crisis (disease)",
          "thyroid storm",
          "thyrotoxic crisis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Acute onset of severe, life-threatening hyperthyroidism caused by a sudden release of excessive thyroid hormone."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006996"
    },
    {
      "id": 9130,
      "label": "selective pituitary resistance to thyroid hormone",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6233,
        24776
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111374",
          "GARD:0024576",
          "MEDGEN:333543",
          "MESH:C564154",
          "OMIM:145650",
          "Orphanet:165994",
          "UMLS:C1840364",
          "icd11.foundation:482664523"
        ],
        "synonyms": [
          "PRTH",
          "hyperthyroidism, familial, due to inappropriate thyrotropin secretion",
          "pituitary resistance to thyroid hormone",
          "thyroid hormone resistance, selective pituitary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pituitary resistance to thyroid hormone is a rare, genetic thyroid disease, due to reduced pituitary gland responsiveness to thyroid hormone, characterized by mild to moderate hyperthyroidism in association with elevated circulating thyroid hormone levels, normal or elevated thyroid stimulating hormone, and no abnormalities of the pituitary gland on MRI. Patients present with diffuse large goiter, tachycardia, atrial fibrillation, weight loss and/or heat intolerance/perspiration, but no exophthalmos or anterior tibial mixedema."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007784"
    },
    {
      "id": 10294,
      "label": "generalized resistance to thyroid hormone",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3557,
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000301",
          "MEDGEN:1654700",
          "Orphanet:3221",
          "UMLS:C4722330"
        ],
        "synonyms": [
          "GRTH",
          "Refetoff syndrome",
          "deafness-thyroid hormone resistance syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A thyroid hormone resistance syndrome characterized by resistance in the pituitary gland and in most or all of the peripheral tissues."
      },
      "child_count": 12,
      "reference_id": "MONDO:0009043"
    },
    {
      "id": 11321,
      "label": "thyrotoxicosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7997",
          "EFO:0009190",
          "ICD10CM:E05",
          "ICD9:242",
          "ICD9:242.80",
          "ICD9:242.90",
          "MEDGEN:11814",
          "MESH:D013971",
          "NCIT:C61469",
          "SCTID:90739004",
          "UMLS:C0040156",
          "icd11.foundation:1470387017"
        ],
        "synonyms": [
          "GRD1",
          "Graves disease, susceptibility to, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis."
      },
      "child_count": 1,
      "reference_id": "MONDO:0010138"
    },
    {
      "id": 12425,
      "label": "familial gestational hyperthyroidism",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6233,
        21520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081102",
          "GARD:0016913",
          "ICD9:242.80",
          "ICD9:648.10",
          "MEDGEN:355106",
          "MESH:C566384",
          "OMIM:603373",
          "Orphanet:99819",
          "SCTID:703309000",
          "UMLS:C1863959",
          "icd11.foundation:811229304"
        ],
        "synonyms": [
          "hyperthyroidism, familial gestational"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011309"
    },
    {
      "id": 13264,
      "label": "familial hyperthyroidism due to mutations in TSH receptor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081101",
          "GARD:0002858",
          "MEDGEN:373154",
          "MESH:C563786",
          "OMIM:609152",
          "Orphanet:424",
          "UMLS:C1836706"
        ],
        "synonyms": [
          "familial non-immune hyperthyroidism",
          "resistance to thyroid stimulating hormone",
          "Nonautoimmune hyperthyroidism",
          "hyperthyroidism, NONAUTOIMMUNE",
          "hyperthyroidism, Nonautoimmune, autosomal dominant",
          "hyperthyroidism, congenital Nonautoimmune",
          "toxic thyroid hyperplasia, autosomal dominant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Familial non-autoimmune autosomal dominant hyperthyroidism (FNAH) is a rare hyperthyroidism characterized by mild to severe hyperthyroidism, presence of goiter, absence of features of autoimmunity, frequent relapses while on treatment and a positive family history."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012203"
    },
    {
      "id": 15448,
      "label": "hyperthyroxinemia, familial dysalbuminemic",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6233,
        7020
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:90974",
          "MESH:D050010",
          "NCIT:C131813",
          "OMIM:615999",
          "Orphanet:276271",
          "SCTID:237547004",
          "UMLS:C0342185"
        ],
        "synonyms": [
          "bisalbuminemia",
          "dysalbuminemic hyperthyroxinemia",
          "dysalbuminemic hypertriiodothyroninemia",
          "familial Dysalbuminemic hyperthyroidism",
          "familial Dysalbuminemic hyperthyroxinemia",
          "hyperthyroxinemia, familial Dysalbuminemic",
          "hyperthyroxinemia, familial dysalbuminemic",
          "FDAH",
          "FDH",
          "euthyroid hyperthyroxinemia 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An inherited autosomal dominant trait characterized by abnormally elevated levels of total serum thyroxine; (T4) in euthyroid patients with abnormal serum albumin that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and tsh are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the alb gene on chromosome 4."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014448"
    },
    {
      "id": 29358,
      "label": "primary hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:811409",
          "UMLS:C3714618"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of hyperthyroidism caused by overproduction of thyroid hormones (T3 and T4) due to pathology within the thyroid gland itself. Primary hyperthyroidism is characterized by low TSH levels and elevated T3/T4 levels."
      },
      "child_count": 3,
      "reference_id": "MONDO:1060200"
    },
    {
      "id": 29359,
      "label": "secondary hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:923144",
          "UMLS:C1095928"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of hyperthyroidism caused by overproduction of thyroid hormones (T3 and T4) due to pathology outside of the thyroid gland, namely in the hypothalamus or pituitary gland. Secondary hyperthyroidism is characterized by elevated TSH levels and elevated T3/T4 levels."
      },
      "child_count": 2,
      "reference_id": "MONDO:1060201"
    }
  ],
  "roots": [
    {
      "id": 5187,
      "label": "thyroid gland disorder"
    }
  ]
}