{
  "id": 6274,
  "label": "anal canal Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004468",
  "properties": {
    "xrefs": [
      "DOID:8119",
      "GARD:0024022",
      "MEDGEN:231062",
      "NCIT:C7477",
      "SCTID:236811000119101",
      "UMLS:C1332261"
    ],
    "synonyms": [
      "Paget disease of the anal canal",
      "Paget's disease of anal canal",
      "Paget's disease of the anal canal",
      "anal canal Paget disease",
      "anal canal Paget's disease",
      "anal canal mammary Paget's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Paget disease involving the squamous epithelium of the anal canal."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4702,
      "label": "anal Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4703,
        9488
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3446",
          "GARD:0023203",
          "MEDGEN:233981",
          "NCIT:C5598",
          "UMLS:C1332274"
        ],
        "synonyms": [
          "Paget disease of the anus",
          "Paget's disease of anus",
          "Paget's disease of the anus",
          "anal Paget disease",
          "anal Paget's disease",
          "anus Paget disease",
          "anus mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A slowly spreading, erythematous eczematoid plaque in the anal region. Histologically, the basal part or whole thickness of the squamous epithelium is infiltrated by large cells with abundant pale cytoplasm and large nuclei. Half of the cases are associated with an internal malignancy, most often a colorectal adenocarcinoma. The other half of the cases, have a high local recurrence rate and they may become invasive (WHO)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002651"
    },
    {
      "id": 4771,
      "label": "anal canal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4703,
        8521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3692",
          "GARD:0021773",
          "HP:0030439",
          "MEDGEN:233977",
          "NCIT:C7471",
          "Orphanet:424016",
          "SCTID:764845008",
          "UMLS:C1332259",
          "icd11.foundation:168138050"
        ],
        "synonyms": [
          "adenocarcinoma arising in anal mucosa",
          "adenocarcinoma arising in the anal mucosa",
          "adenocarcinoma of anal canal",
          "adenocarcinoma of the anal canal",
          "anal canal adenocarcinoma",
          "anal canal adenocarcinoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An anal adenocarcinoma arising from the anal canal mucosa. Morphologically, it resembles the adenocarcinoma which arises from the colorectal glandular epithelium. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002735"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4702,
      "label": "anal Paget disease"
    },
    {
      "id": 4771,
      "label": "anal canal adenocarcinoma"
    }
  ]
}