{
  "id": 6299,
  "label": "tertiary syphilis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004497",
  "properties": {
    "xrefs": [
      "DOID:8200",
      "GARD:0027683",
      "ICD10CM:A52",
      "ICD9:095.8",
      "ICD9:095.9",
      "ICD9:097.0",
      "MEDGEN:56297",
      "MESH:C536774",
      "NCIT:C128414",
      "SCTID:72083004",
      "UMLS:C0153188"
    ],
    "synonyms": [
      "late syphilis",
      "late tertiary syphilis",
      "tertiary syphilis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A stage of syphilis that occurs fifteen to thirty years after the initial infection; it can include gumma formation and cardiovascular or central nervous system involvement (neurosyphilis)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7568,
      "label": "syphilis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2837,
        8423
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4166",
          "EFO:0007504",
          "GARD:0027732",
          "ICD9:097.9",
          "MEDGEN:21447",
          "MESH:D013587",
          "MedDRA:10062120",
          "NCIT:C35055",
          "SCTID:76272004",
          "UMLS:C0039128",
          "icd11.foundation:455894495"
        ],
        "synonyms": [
          "Treponema pallidum caused disease or disorder",
          "Treponema pallidum disease or disorder",
          "Treponema pallidum infectious disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A contagious bacterial infection caused by the spirochete Treponema pallidum. It is a sexually transmitted disorder, although it can also be transmitted from the mother to the fetus in utero. Typically, it is initially manifested with a single sore which heals without treatment. If the infection is left untreated, the initial stage is followed by skin rash and mucous membrane lesions. A late stage follows, which is characterized by damage of the internal organs, including the nervous system."
      },
      "child_count": 20,
      "reference_id": "MONDO:0005976"
    }
  ],
  "children": [
    {
      "id": 2865,
      "label": "gummatous syphilis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6299
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050584",
          "GARD:0027524",
          "icd11.foundation:1630654348"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A tertiary syphilis that is characterized by granulomatous lesions, called gummas, which are characterized by a center of necrotic tissue with a rubbery texture. They form in the liver, bones, and testes but may affect any organ."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000363"
    },
    {
      "id": 6663,
      "label": "cardiovascular syphilis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6299
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9880",
          "GARD:0027709",
          "ICD9:093.8",
          "ICD9:093.89",
          "ICD9:093.9",
          "MEDGEN:21055",
          "SCTID:83883001",
          "UMLS:C0039130",
          "icd11.foundation:183283901"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004911"
    },
    {
      "id": 6690,
      "label": "neurosyphilis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6299
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9988",
          "GARD:0008729",
          "ICD10CM:A52.3",
          "ICD9:094",
          "ICD9:094.89",
          "ICD9:094.9",
          "MEDGEN:14360",
          "MESH:D009494",
          "NCIT:C84935",
          "SCTID:26039008",
          "UMLS:C0027927",
          "icd11.foundation:2118246468"
        ],
        "synonyms": [
          "neurosyphilis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Infection of the brain or spinal cord by Treponema pallidum. It occurs many years following the original infection which remained untreated. Signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004944"
    },
    {
      "id": 23017,
      "label": "late latent syphilis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6299,
        7436
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027960",
          "MEDGEN:687555",
          "NCIT:C128371",
          "SCTID:186903006",
          "UMLS:C1260915"
        ],
        "synonyms": [
          "late latent syphilis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Latent syphilis when infection was acquired more than twelve months previously."
      },
      "child_count": 0,
      "reference_id": "MONDO:0040923"
    }
  ],
  "roots": [
    {
      "id": 7568,
      "label": "syphilis"
    }
  ]
}