{
  "id": 6392,
  "label": "monocytic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004600",
  "properties": {
    "xrefs": [
      "DOID:8527",
      "GARD:0024074",
      "ICD10CM:C93",
      "ICD9:206.8",
      "ICD9:206.80",
      "ICD9:206.81",
      "ICD9:206.90",
      "ICD9:206.91",
      "MEDGEN:109338",
      "SCTID:188744006",
      "UMLS:C0598894"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6789,
      "label": "leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1240",
          "EFO:0000565",
          "HP:0001909",
          "ICD9:207",
          "ICD9:207.8",
          "ICD9:207.80",
          "ICD9:208",
          "ICD9:208.8",
          "ICD9:208.80",
          "ICD9:208.9",
          "ICD9:208.90",
          "ICDO:9800/3",
          "MEDGEN:9725",
          "MESH:D007938",
          "NANDO:2100002",
          "NCIT:C3161",
          "SCTID:93143009",
          "UMLS:C0023418"
        ],
        "synonyms": [
          "blood (leukemia)",
          "leukaemia (disease)",
          "leukemia",
          "leukemia (disease)",
          "leukemia, disease",
          "leukemia, malignant",
          "leukemias",
          "leukemias, general",
          "leukaemia NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005059"
    }
  ],
  "children": [
    {
      "id": 6403,
      "label": "chronic monocytic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3274,
        6392
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8593",
          "GARD:0024075",
          "ICD9:206.1",
          "ICD9:206.10",
          "ICD9:206.11",
          "MEDGEN:9729",
          "NCIT:C34774",
          "SCTID:188745007",
          "UMLS:C0023466"
        ],
        "synonyms": [
          "monocytic leukemia, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (myeloid progenitor cells) in the bone marrow and other sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004614"
    },
    {
      "id": 9231,
      "label": "acute monocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6392,
        18806
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2004-2820",
          "DOID:8864",
          "EFO:0000221",
          "GARD:0000525",
          "ICD10CM:C93.0",
          "ICD9:206.0",
          "ICDO:9891/3",
          "MEDGEN:7319",
          "MESH:D007948",
          "MedDRA:10000871",
          "MedDRA:10059439",
          "NANDO:2200008",
          "NANDO:2200009",
          "NCIT:C4861",
          "OMIM:151380",
          "ONCOTREE:AMOL",
          "Orphanet:514",
          "SCTID:413441006",
          "UMLS:C0023465",
          "icd11.foundation:517546180"
        ],
        "synonyms": [
          "monocytic leukaemia",
          "monocytic leukemia",
          "AML M5",
          "acute monoblastic leukaemia and acute monocytic leukaemia",
          "acute monocytic leukaemia (FAB M5B)",
          "acute monocytic leukaemia (FAB M5b)",
          "acute monocytic leukemia",
          "acute monocytic leukemia (FAB M5B)",
          "acute monocytic leukemia (FAB M5b)",
          "acute monocytic leukemia, morphology (morphologic abnormality)",
          "leukemia, monocytic, malignant",
          "monocytic leukemia, acute",
          "AML-M5",
          "acute monoblastic leukaemia",
          "acute monoblastic leukemia",
          "acute monoblastic/monocytic leukaemia",
          "acute monoblastic/monocytic leukemia",
          "acute myeloblastic leukaemia type 5",
          "acute myeloblastic leukemia type 5",
          "leukemia, acute monocytic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0007896"
    }
  ],
  "roots": [
    {
      "id": 6789,
      "label": "leukemia"
    }
  ]
}