{
  "id": 6399,
  "label": "herpes simplex infectious disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004609",
  "properties": {
    "xrefs": [
      "DOID:8566",
      "EFO:1002022",
      "ICD10CM:B00",
      "ICD9:054",
      "ICD9:058.89",
      "MEDGEN:9234",
      "MESH:D006561",
      "SCTID:88594005",
      "UMLS:C0019348"
    ],
    "synonyms": [
      "Simplexvirus caused disease or disorder",
      "Simplexvirus disease or disorder",
      "Simplexvirus infectious disease",
      "herpes simplex",
      "herpes simplex complex",
      "herpes simplex infection",
      "herpes simplex viral infection"
    ],
    "definition": "A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 7411,
      "label": "Herpesviridae infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24062
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007309",
          "MESH:D006566",
          "SCTID:23513009"
        ],
        "synonyms": [
          "Herpesviridae caused disease or disorder",
          "Herpesviridae disease or disorder",
          "Herpesviridae infections",
          "herpesvirus infection",
          "Herpesviridae infection",
          "Herpesvirus infection",
          "Herpesvirus infections",
          "herpes infection",
          "infection, Herpesviridae",
          "infection, Herpesvirus",
          "infections, Herpesviridae",
          "infections, Herpesvirus"
        ],
        "definition": "Virus diseases caused by the herpesviridae."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005794"
    }
  ],
  "children": [
    {
      "id": 6405,
      "label": "herpetic whitlow",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6399,
        7501,
        21328,
        21440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8607",
          "ICD9:054.6",
          "MEDGEN:509122",
          "NCIT:C128402",
          "SCTID:43891009",
          "UMLS:C0153042"
        ],
        "synonyms": [
          "Simplexvirus caused paronychia (disease)",
          "Simplexvirus paronychia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A painful blister of the periungual skin that is caused by herpes simplex virus type 1 or 2."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004616"
    },
    {
      "id": 6490,
      "label": "herpes simplex dermatitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6399,
        20419
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9123",
          "ICD10CM:B00.0",
          "ICD9:054.0",
          "ICD9:054.41",
          "MEDGEN:163132",
          "MESH:D007617",
          "NCIT:C35620",
          "SCTID:186535001",
          "UMLS:C0854331"
        ],
        "synonyms": [
          "Herpes simplex dermatitis",
          "Simplexvirus caused dermatitis",
          "Simplexvirus dermatitis",
          "eczema herpeticum (disorder) [ambiguous]",
          "herpes simplex dermatitis",
          "Herpes simplex dermatitis of eyelid",
          "Herpes simplex eyelid dermatitis",
          "herpes simplex virus eyelid dermatitis",
          "eczema herpeticum"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Localized rash characterized by grouped vesicles or pustules on an erythematous base that is caused by herpes simplex virus infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004712"
    },
    {
      "id": 7390,
      "label": "genital herpes",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6399,
        20727,
        24063
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8704",
          "EFO:0007282",
          "ICD9:054.1",
          "ICD9:054.10",
          "ICD9:054.19",
          "MEDGEN:42436",
          "MESH:D006558",
          "NCIT:C14364",
          "SCTID:33839006",
          "UMLS:C0019342"
        ],
        "synonyms": [
          "herpes genitalia",
          "herpes genitalis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Herpes simplex infection of the genitals, most commonly caused by the herpes simplex-2 virus."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005770"
    },
    {
      "id": 7410,
      "label": "herpes simplex virus gingivostomatitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6399,
        6599
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007307",
          "MESH:D013283",
          "SCTID:57920007"
        ],
        "synonyms": [
          "Simplexvirus caused stomatitis",
          "Simplexvirus stomatitis",
          "Gingivostomatitides, herpetic",
          "Gingivostomatitis, herpetic",
          "Herpes simplex, oral",
          "Stomatitides, herpetic",
          "herpetic Gingivostomatitides",
          "herpetic Gingivostomatitis",
          "herpetic Stomatitides",
          "herpetic stomatitis",
          "oral Herpes simplex",
          "simplex, oral Herpes"
        ],
        "categories": [
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005792"
    },
    {
      "id": 13569,
      "label": "herpes simplex encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6399,
        7600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006649",
          "MEDGEN:75794",
          "MESH:D020803",
          "NANDO:2200772",
          "NCIT:C84762",
          "NORD:1087",
          "Orphanet:1930",
          "UMLS:C0276226",
          "icd11.foundation:320069644"
        ],
        "synonyms": [
          "Encephalitis, Herpes Simplex",
          "HSE",
          "HSV encephalitis",
          "HSVE",
          "Herpes simplex meningo-encephalitis",
          "Herpes simplex neuroinvasion",
          "Simplexvirus caused infectious encephalitis",
          "Simplexvirus infectious encephalitis",
          "herpetic encephalitis",
          "Herpes simplex virus encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Herpes simplex virus encephalitis (HSE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSV often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012521"
    },
    {
      "id": 16169,
      "label": "herpes simplex virus keratitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6399,
        20248,
        21277
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080158",
          "EFO:0007308",
          "GARD:0025063",
          "MEDGEN:5534",
          "NCIT:C34743",
          "Orphanet:137586",
          "SCTID:9389005",
          "UMLS:C0019357"
        ],
        "synonyms": [
          "HSV keratitis",
          "Simplexvirus caused keratitis",
          "Simplexvirus keratitis",
          "dendritic keratitis",
          "herpetic keratitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (keratitis, dendritic). (Dictionary of Visual Science, 3d ed)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0015288"
    },
    {
      "id": 17690,
      "label": "congenital herpes simplex virus infection",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6399,
        23097
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018687",
          "ICD9:771.2",
          "MEDGEN:82910",
          "NANDO:2200889",
          "Orphanet:293",
          "SCTID:91576008",
          "UMLS:C0276225"
        ],
        "synonyms": [
          "Simplexvirus caused infectious embryofetopathy",
          "Simplexvirus infectious embryofetopathy",
          "antenatal herpes simplex virus infection",
          "congenital herpes simplex",
          "mother-to-child transmission of herpes simplex virus infection",
          "congenital herpes simplex infection",
          "neonatal HSV infection",
          "neonatal herpes simplex",
          "neonatal herpes simplex virus infection"
        ],
        "definition": "Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent fetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs, such as the liver or central nervous system, are less frequent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017381"
    },
    {
      "id": 23233,
      "label": "herpes labialis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6399,
        6519,
        24063
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:5533",
          "MESH:D006560",
          "NCIT:C34695",
          "SCTID:1475003",
          "UMLS:C0019345"
        ],
        "synonyms": [
          "cold sore",
          "cold sores",
          "herpes labialis",
          "Herpes simplex, labial",
          "Sore, cold",
          "Sores, cold",
          "blister, fever",
          "blisters, fever",
          "fever blister",
          "fever blisters",
          "herpes simplex labialis",
          "labial Herpes simplex"
        ],
        "categories": [
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A lesion caused by type 1 or type 2 herpes simplex virus, typically involving the oralfacial region."
      },
      "child_count": 6,
      "reference_id": "MONDO:0043653"
    },
    {
      "id": 24087,
      "label": "herpes simplex type 1 infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6399
      ],
      "type_id": 0,
      "properties": {
        "definition": "A disease caused by infection with herpes simplex type 1."
      },
      "child_count": 2,
      "reference_id": "MONDO:0100359"
    },
    {
      "id": 24088,
      "label": "herpes simplex type 2 infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6399
      ],
      "type_id": 0,
      "properties": {
        "definition": "A disease caused by infection with herpes simplex type 2."
      },
      "child_count": 2,
      "reference_id": "MONDO:0100360"
    }
  ],
  "roots": [
    {
      "id": 7411,
      "label": "Herpesviridae infectious disease"
    }
  ]
}