{
  "id": 6420,
  "label": "vein disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004634",
  "properties": {
    "xrefs": [
      "DOID:866",
      "ICD9:453",
      "MEDGEN:115992",
      "NCIT:C35279",
      "SCTID:90507008",
      "UMLS:C0235522"
    ],
    "synonyms": [
      "disease of vein",
      "disease or disorder of vein",
      "disorder of vein",
      "vein disease",
      "vein disease or disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A disease involving the vein."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    }
  ],
  "children": [
    {
      "id": 3214,
      "label": "venous insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6420,
        20084
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10128",
          "HP:0005293",
          "ICD9:459.81",
          "MEDGEN:21841",
          "MESH:D014689",
          "SCTID:20696009",
          "UMLS:C0042485"
        ],
        "synonyms": [
          "venous insufficiency",
          "venous insufficiency (disease)",
          "peripheral venous insufficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with edema and sometimes with venous stasis ulcers at the ankle."
      },
      "child_count": 4,
      "reference_id": "MONDO:0000945"
    },
    {
      "id": 3567,
      "label": "portal vein thrombosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3150,
        4495,
        6420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11695",
          "ICD10CM:I81",
          "ICD10WHO:I81",
          "ICD9:452",
          "MEDGEN:56372",
          "NCIT:C78565",
          "SCTID:17920008",
          "UMLS:C0155773",
          "icd11.foundation:866276949"
        ],
        "synonyms": [
          "portal vein thrombotic disease",
          "thrombotic disease of portal vein"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The formation of a blood clot (thrombus) in the portal vein."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001339"
    },
    {
      "id": 3920,
      "label": "occlusion of tributary of retinal vein",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6420,
        8380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13514",
          "ICD9:362.36"
        ],
        "synonyms": [
          "venous tributary (branch) occlusion of retina"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001733"
    },
    {
      "id": 4411,
      "label": "central retinal vein occlusion",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6420,
        8380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2450",
          "GARD:0021734",
          "ICD10CM:H34.81",
          "ICD9:362.35",
          "MEDGEN:509679",
          "NCIT:C118859",
          "Orphanet:411527",
          "SCTID:68478007",
          "UMLS:C0154841",
          "icd11.foundation:1146548497"
        ],
        "synonyms": [
          "central retinal Venous occlusion",
          "central retinal vein retinal vein occlusion",
          "retinal vein occlusion of central retinal vein"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Blockage of the central retinal vein."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002303"
    },
    {
      "id": 4995,
      "label": "cavernous sinus meningioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4997,
        6420,
        20321,
        21452,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4435",
          "GARD:0023317",
          "MEDGEN:232034",
          "NCIT:C5268",
          "UMLS:C1332865"
        ],
        "synonyms": [
          "cavernous sinus meningioma (disease)",
          "meningioma (disease) of cavernous sinus",
          "meningioma of cavernous sinus",
          "meningioma of the cavernous sinus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A meningioma that affects the cavernous sinus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002996"
    },
    {
      "id": 5025,
      "label": "superior vena cava angiosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6420,
        17394,
        23003
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4522",
          "GARD:0023338",
          "MEDGEN:234373",
          "NCIT:C5378",
          "UMLS:C1336530"
        ],
        "synonyms": [
          "angiosarcoma (disease) of anterior vena cava",
          "angiosarcoma of Superior vena cava",
          "angiosarcoma of the Superior vena cava",
          "anterior vena cava angiosarcoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A malignant vascular neoplasm arising from the superior vena cava."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003032"
    },
    {
      "id": 6028,
      "label": "pulmonary vein leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6420,
        6788,
        17394,
        23003
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7388",
          "GARD:0023875",
          "MEDGEN:235513",
          "NCIT:C5374",
          "UMLS:C1335575"
        ],
        "synonyms": [
          "leiomyosarcoma of pulmonary vein",
          "leiomyosarcoma of the pulmonary vein",
          "pulmonary vein leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the pulmonary vein. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004206"
    },
    {
      "id": 6413,
      "label": "phlebitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6420,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:864",
          "EFO:1001395",
          "MEDGEN:18425",
          "MESH:D010689",
          "NCIT:C38003",
          "SCTID:61599003",
          "UMLS:C0031542"
        ],
        "synonyms": [
          "inflammation of vein",
          "vein inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of a vein."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004625"
    },
    {
      "id": 7833,
      "label": "malignant jugulotympanic paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4233,
        4265,
        4753,
        6420,
        20305,
        20310,
        20329,
        21452,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024363",
          "MEDGEN:87584",
          "NCIT:C4623",
          "UMLS:C0347856"
        ],
        "synonyms": [
          "cancer of jugular body",
          "jugular body cancer",
          "malignant glomus jugulare neoplasm",
          "malignant glomus jugulare tumor",
          "malignant glomus jugulare tumour",
          "malignant jugular body neoplasm",
          "malignant jugulotympanic paraganglioma",
          "malignant neoplasm of glomus jugulare",
          "malignant neoplasm of jugular body",
          "malignant neoplasm of the glomus jugulare",
          "malignant tumor of glomus jugulare",
          "malignant tumor of the glomus jugulare",
          "malignant tumour of glomus jugulare",
          "malignant tumour of the glomus jugulare"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A jugulotympanic paraganglioma that metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006291"
    },
    {
      "id": 9920,
      "label": "varicose disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:799",
          "ICD9:454.9",
          "ICD9:456.8",
          "MEDGEN:21827",
          "MESH:D014648",
          "NCIT:C35114",
          "OMIM:192200",
          "SCTID:128060009",
          "UMLS:C0042345"
        ],
        "synonyms": [
          "varix",
          "varices",
          "varicose veins"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A vascular disease characterized by the presence of enlarged and tortuous veins."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008638"
    },
    {
      "id": 16108,
      "label": "vein of Galen aneurysm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3493,
        5807,
        6420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005467",
          "MEDGEN:140912",
          "MESH:C536535",
          "NCIT:C98642",
          "Orphanet:1053",
          "SCTID:253194008",
          "UMLS:C0431420",
          "icd11.foundation:1884295064"
        ],
        "synonyms": [
          "vein of Galen arteriovenous malformations",
          "Galen vein aneurysm",
          "Galenic arteriovenous malformation",
          "VGAM",
          "ectasia or varix of the vein of Galen",
          "vein of Galen aneurysm malformation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Vein of Galen aneurysm is a rare formof arteriovenous malformation in which the embryonic precursor to the vein of Galen, a vein at the base of the brain, dilates causing too much blood to rush to the heart. This can lead to rapid heart failure. Other features may include increased head circumference resulting from hydrocephalus, unusually prominent veins on the face and scalp, developmental delay, persistent headache, and other neurological findings. Vein of Galen aneurysm is often recognized on an ultrasound late in pregnancy. In other cases, it is diagnosed after birth. Although the exact cause remains unknown, this condition appears to result from a defect in early fetal development. Treatment is aimed at decreasing the blood flow through the malformation while maximizing the blood supply to the brain. Minimally invasive surgical techniques are preferred, such as endovascular embolization."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015196"
    },
    {
      "id": 22795,
      "label": "isolated splenic vein thrombosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3150,
        6420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022338",
          "MEDGEN:544034",
          "Orphanet:583856",
          "UMLS:C0272416",
          "icd11.foundation:121618859"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035008"
    },
    {
      "id": 22796,
      "label": "isolated mesenteric vein thrombosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3150,
        6420,
        6756
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022339",
          "MEDGEN:120599",
          "Orphanet:583861",
          "UMLS:C0267412",
          "icd11.foundation:213868120"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035009"
    }
  ],
  "roots": [
    {
      "id": 7065,
      "label": "vascular disorder"
    }
  ]
}