{
  "id": 6429,
  "label": "myeloid leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004643",
  "properties": {
    "xrefs": [
      "DOID:8692",
      "GARD:0008226",
      "ICD10CM:C92",
      "ICD9:205",
      "ICD9:205.80",
      "ICD9:205.9",
      "ICD9:205.90",
      "ICDO:9860/3",
      "MEDGEN:7320",
      "MESH:D007951",
      "NCIT:C3172",
      "SCTID:188732008",
      "UMLS:C0023470"
    ],
    "synonyms": [
      "leukaemia granulocytic",
      "leukaemia myeloid",
      "leukemia granulocytic",
      "leukemia myelogenous",
      "leukemia myeloid",
      "leukemia, granulocytic, malignant",
      "myelocytic leukaemia",
      "myelocytic leukemia",
      "myelogenous leukaemia",
      "myelogenous leukemia",
      "myeloid leukemia",
      "non-lymphoblastic leukaemia",
      "non-lymphoblastic leukemia",
      "non-lymphocytic leukaemia",
      "non-lymphocytic leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6789,
      "label": "leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1240",
          "EFO:0000565",
          "HP:0001909",
          "ICD9:207",
          "ICD9:207.8",
          "ICD9:207.80",
          "ICD9:208",
          "ICD9:208.8",
          "ICD9:208.80",
          "ICD9:208.9",
          "ICD9:208.90",
          "ICDO:9800/3",
          "MEDGEN:9725",
          "MESH:D007938",
          "NANDO:2100002",
          "NCIT:C3161",
          "SCTID:93143009",
          "UMLS:C0023418"
        ],
        "synonyms": [
          "blood (leukemia)",
          "leukaemia (disease)",
          "leukemia",
          "leukemia (disease)",
          "leukemia, disease",
          "leukemia, malignant",
          "leukemias",
          "leukemias, general",
          "leukaemia NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005059"
    },
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6892,
        16513,
        20376
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2226",
          "EFO:0002428",
          "GARD:0009319",
          "ICD9:238.79",
          "ICDO:9960/3",
          "ICDO:9975/1",
          "MEDGEN:220955",
          "MedDRA:10028576",
          "NCIT:C4345",
          "ONCOTREE:MPN",
          "Orphanet:98274",
          "SCTID:425333006",
          "UMLS:C1292778"
        ],
        "synonyms": [
          "CMPD",
          "MPD",
          "MPN",
          "chronic myeloproliferative disease",
          "chronic myeloproliferative disorder",
          "chronic myeloproliferative neoplasm",
          "myeloproliferative disorder",
          "myeloproliferative neoplasm",
          "myeloproliferative neoplasm, chronic",
          "myeloproliferative tumor",
          "myeloproliferative tumour",
          "CMPD, U",
          "chronic myeloproliferative disorders",
          "myeloproliferative neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)"
      },
      "child_count": 39,
      "reference_id": "MONDO:0020076"
    }
  ],
  "children": [
    {
      "id": 6439,
      "label": "atypical chronic myeloid leukemia, BCR-ABL1 negative",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6429,
        7847,
        19728
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060597",
          "DOID:8747",
          "GARD:0019583",
          "ICDO:9876/3",
          "MEDGEN:266233",
          "MedDRA:10054651",
          "NCIT:C3519",
          "Orphanet:98824",
          "SCTID:277589003",
          "UMLS:C1292772",
          "icd11.foundation:331838766"
        ],
        "synonyms": [
          "aCML",
          "atypical CML",
          "atypical chronic myeloid leukaemia",
          "atypical chronic myeloid leukemia",
          "atypical chronic myeloid leukemia, BCR-ABL1 Negative",
          "subacute granulocytic leukaemia",
          "subacute granulocytic leukemia",
          "subacute myelogenous leukaemia",
          "subacute myelogenous leukemia",
          "subacute myeloid leukaemia",
          "subacute myeloid leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myelodysplastic/myeloproliferative neoplasm characterized by the principal involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene. (WHO, 2001)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004653"
    },
    {
      "id": 13067,
      "label": "chronic myelogenous leukemia, BCR-ABL1 positive",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081088",
          "DOID:8552",
          "EFO:0000339",
          "GARD:0006105",
          "ICD9:205.1",
          "ICDO:9863/3",
          "ICDO:9875/3",
          "MEDGEN:75993",
          "MedDRA:10009013",
          "NANDO:2200013",
          "NCIT:C3174",
          "OMIM:608232",
          "ONCOTREE:CML",
          "Orphanet:521",
          "UMLS:C0279543"
        ],
        "synonyms": [
          "BCR-ABL Positive chronic myelogenous leukaemia",
          "BCR-ABL Positive chronic myelogenous leukemia",
          "CML",
          "CML - chronic myelogenous leukaemia",
          "CML - chronic myelogenous leukemia",
          "chronic granulocytic leukemia",
          "chronic myelocytic leukaemia",
          "chronic myelocytic leukemia",
          "chronic myelogenous leukaemia (CML)",
          "chronic myelogenous leukemia",
          "chronic myelogenous leukemia (CML)",
          "chronic myelogenous leukemia, BCR-ABL1 Positive",
          "chronic myelogenous leukemias",
          "chronic myeloid leukemia",
          "hematopoeitic - chronic myelocytic leukaemia (CML)",
          "hematopoeitic - chronic myelocytic leukemia (CML)",
          "leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation",
          "leukemia, chronic myeloid, Philadelphia chromosome positive, somatic",
          "myeloid leukemia, chronic",
          "leukemia, chronic myelogenous",
          "leukemia, chronic myeloid",
          "leukemia, chronic myeloid, atypical"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival."
      },
      "child_count": 6,
      "reference_id": "MONDO:0011996"
    },
    {
      "id": 18806,
      "label": "acute myeloid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        11789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9119",
          "EFO:0000222",
          "GARD:0012757",
          "ICD10CM:C92.0",
          "ICD9:205.0",
          "ICD9:205.00",
          "ICDO:9861/3",
          "MEDGEN:9730",
          "MESH:D015470",
          "MedDRA:10000880",
          "NCIT:C3171",
          "NORD:1905",
          "OMIM:601626",
          "ONCOTREE:AML",
          "Orphanet:519",
          "SCTID:91861009",
          "UMLS:C0023467"
        ],
        "synonyms": [
          "AML",
          "AML - acute myeloid leukaemia",
          "AML - acute myeloid leukemia",
          "ANLL",
          "acute Nonlymphocytic leukaemia",
          "acute Nonlymphocytic leukemia",
          "acute granulocytic leukaemia",
          "acute granulocytic leukemia",
          "acute myeloblastic leukemia",
          "acute myelocytic leukaemia",
          "acute myelocytic leukemia",
          "acute myelogenous leukemia",
          "acute myelogenous leukemias",
          "acute myeloid leukaemia (AML)",
          "acute myeloid leukemia",
          "acute myeloid leukemia (AML)",
          "acute myeloid leukemia, somatic",
          "acute nonlymphocytic leukaemia",
          "acute nonlymphocytic leukemia",
          "hematopoeitic - acute Myleogenous leukaemia (AML)",
          "hematopoeitic - acute Myleogenous leukemia (AML)",
          "leukemia, acute myeloid, autosomal dominant, somatic mutation",
          "leukemia, acute myeloid, reduced survival in, somatic",
          "leukemia, acute myeloid, somatic",
          "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation",
          "leukemia, myelocytic, acute",
          "myeloid leukemia, acute",
          "myeloid leukemia, acute, M4/M4Eo subtype, somatic",
          "acute non lymphoblastic leukaemia",
          "acute non lymphoblastic leukemia",
          "leukemia, acute myelogenous",
          "leukemia, acute myeloid",
          "leukemia, acute myeloid, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections."
      },
      "child_count": 156,
      "reference_id": "MONDO:0018874"
    },
    {
      "id": 21579,
      "label": "Philadelphia-positive myelogenous leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6429
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025459",
          "MEDGEN:9731",
          "NCIT:C3177",
          "UMLS:C0023476"
        ],
        "synonyms": [
          "Ph1-positive granulocytic leukaemia",
          "Ph1-positive granulocytic leukemia",
          "Ph1-positive myelocytic leukaemia",
          "Ph1-positive myelocytic leukemia",
          "Ph1-positive myelogenous leukaemia",
          "Ph1-positive myelogenous leukemia",
          "Ph1-positive myeloid leukaemia",
          "Ph1-positive myeloid leukemia",
          "Philadelphia-positive granulocytic leukaemia",
          "Philadelphia-positive granulocytic leukemia",
          "Philadelphia-positive myelocytic leukaemia",
          "Philadelphia-positive myelocytic leukemia",
          "Philadelphia-positive myelogenous leukemia",
          "Philadelphia-positive myeloid leukaemia",
          "Philadelphia-positive myeloid leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0024685"
    }
  ],
  "roots": [
    {
      "id": 6789,
      "label": "leukemia"
    },
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm"
    }
  ]
}