{
  "id": 6442,
  "label": "breast carcinoma in situ",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004658",
  "properties": {
    "xrefs": [
      "DOID:8791",
      "ICD10CM:D05",
      "ICD9:233.0",
      "MEDGEN:57817",
      "MESH:D000071960",
      "NCIT:C3641",
      "SCTID:189336000",
      "UMLS:C0154084",
      "icd11.foundation:1264360394"
    ],
    "synonyms": [
      "breast cancer in situ",
      "breast cancer stage 0",
      "breast carcinoma in situ",
      "breast in situ carcinoma",
      "carcinoma in situ of breast",
      "carcinoma in situ of the breast",
      "in situ breast cancer",
      "non-infiltrating breast carcinoma",
      "non-infiltrating carcinoma of breast",
      "non-infiltrating carcinoma of the breast",
      "non-invasive breast carcinoma",
      "non-invasive carcinoma of breast",
      "non-invasive carcinoma of the breast",
      "stage 0 breast cancer",
      "stage 0 breast cancer aJCC v6",
      "stage 0 breast cancer aJCC v6 and v7",
      "stage 0 breast cancer aJCC v7",
      "stage 0 breast carcinoma",
      "stage 0 breast carcinoma in situ",
      "stage 0 carcinoma of breast",
      "stage 0 carcinoma of the breast"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A in situ carcinoma that involves the breast."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6433,
      "label": "in situ carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20078,
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8719",
          "ICD9:230-234",
          "ICD9:234.8",
          "ICD9:234.9",
          "ICDO:8010/2",
          "MEDGEN:763",
          "MESH:D002278",
          "NCIT:C2917",
          "SCTID:109355002",
          "UMLS:C0007099"
        ],
        "synonyms": [
          "CIS",
          "carcinoma in situ",
          "carcinoma, in situ, malignant",
          "epithelial tumor, in situ, malignant",
          "intraepithelial carcinoma",
          "non-invasive carcinoma",
          "stage 0 disease"
        ],
        "definition": "A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion."
      },
      "child_count": 63,
      "reference_id": "MONDO:0004647"
    },
    {
      "id": 6730,
      "label": "breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        8659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3459",
          "EFO:0000305",
          "HP:0003002",
          "MEDGEN:146260",
          "NCIT:C4872",
          "SCTID:254838004",
          "UMLS:C0678222"
        ],
        "synonyms": [
          "breast cancer",
          "breast cancer, NOS",
          "cancer of breast",
          "cancer of the breast",
          "cancer, breast",
          "breast carcinoma",
          "carcinoma of breast",
          "carcinoma of the breast",
          "mammary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the breast"
      },
      "child_count": 26,
      "reference_id": "MONDO:0004989"
    }
  ],
  "children": [
    {
      "id": 4565,
      "label": "lobular neoplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3010",
          "MEDGEN:167824",
          "NCIT:C27939",
          "UMLS:C0861352"
        ],
        "synonyms": [
          "LIN",
          "LN",
          "lobular intraepithelial neoplasia",
          "lobular neoplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A spectrum of non-invasive neoplastic lesions that arise from the terminal ductal lobular units of the breast. There is atypical small epithelial cell proliferation. Pagetoid involvement of the terminal ducts may or may not be present. In the minority of cases, there is a risk for subsequent development of invasive ductal or invasive lobular carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002486"
    },
    {
      "id": 6360,
      "label": "breast apocrine carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8428",
          "MEDGEN:231073",
          "NCIT:C5140",
          "UMLS:C1332315"
        ],
        "synonyms": [
          "apocrine breast carcinoma in situ",
          "apocrine carcinoma in situ of breast",
          "apocrine carcinoma in situ of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A ductal breast carcinoma in situ, characterized by the presence of neoplastic epithelial cells with apocrine differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004562"
    },
    {
      "id": 6758,
      "label": "ductal breast carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5172,
        5857,
        6442,
        7234
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060074",
          "EFO:0000432",
          "ICDO:8500/2",
          "MEDGEN:765",
          "MESH:D002285",
          "NCIT:C2924",
          "ONCOTREE:DCIS",
          "UMLS:C0007124"
        ],
        "synonyms": [
          "DCIS",
          "carcinoma in situ of mammary duct",
          "ductal breast carcinoma in situ",
          "ductal carcinoma in situ",
          "ductal carcinoma in situ (DCIS)",
          "ductal carcinoma in situ of breast",
          "ductal carcinoma in situ of the breast",
          "intraductal breast carcinoma",
          "intraductal carcinoma",
          "intraductal carcinoma of breast",
          "intraductal carcinoma of the breast",
          "mammary duct carcinoma in situ",
          "mammary duct in situ carcinoma",
          "non-infiltrating ductal adenocarcinoma of breast",
          "non-infiltrating ductal adenocarcinoma of the breast",
          "non-infiltrating ductal breast adenocarcinoma",
          "non-infiltrating ductal breast carcinoma",
          "non-infiltrating ductal carcinoma of breast",
          "non-infiltrating ductal carcinoma of the breast",
          "non-infiltrating intraductal adenocarcinoma",
          "non-infiltrating intraductal adenocarcinoma of breast",
          "non-infiltrating intraductal adenocarcinoma of the breast",
          "non-infiltrating intraductal breast adenocarcinoma",
          "non-infiltrating intraductal carcinoma",
          "non-invasive ductal adenocarcinoma of breast",
          "non-invasive ductal adenocarcinoma of the breast",
          "non-invasive ductal breast adenocarcinoma",
          "non-invasive ductal breast carcinoma",
          "non-invasive ductal carcinoma of breast",
          "non-invasive ductal carcinoma of the breast",
          "non-invasive intraductal adenocarcinoma of breast",
          "non-invasive intraductal adenocarcinoma of the breast",
          "non-invasive intraductal breast adenocarcinoma",
          "stage 0 mammary duct carcinoma",
          "breast ductal carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005023"
    },
    {
      "id": 7741,
      "label": "ductal breast carcinoma in situ and lobular carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000221",
          "ICDO:8522/2",
          "MEDGEN:83137",
          "NCIT:C4195",
          "UMLS:C0334383"
        ],
        "synonyms": [
          "DCIS and LCIS of breast",
          "DCIS and LCIS of the breast",
          "ductal and lobular breast carcinoma in situ",
          "ductal and lobular carcinoma in situ of breast",
          "ductal and lobular carcinoma in situ of the breast",
          "ductal carcinoma in situ with lobular carcinoma in situ of breast",
          "ductal carcinoma in situ with lobular carcinoma in situ of the breast",
          "intraductal and lobular breast carcinoma in situ",
          "intraductal and lobular carcinoma in situ of breast",
          "intraductal and lobular carcinoma in situ of the breast",
          "intraductal carcinoma and lobular carcinoma in situ",
          "non-infiltrating ductal and non-infiltrating lobular breast carcinoma",
          "non-infiltrating ductal with non-infiltrating lobular carcinoma of breast",
          "non-infiltrating ductal with non-infiltrating lobular carcinoma of the breast",
          "non-invasive ductal and non-invasive lobular breast carcinoma",
          "non-invasive ductal and non-invasive lobular carcinoma",
          "non-invasive ductal breast carcinoma with non-invasive lobular breast carcinoma",
          "non-invasive ductal carcinoma with non-invasive lobular carcinoma of breast",
          "non-invasive ductal carcinoma with non-invasive lobular carcinoma of the breast",
          "non-invasive ductal with non-invasive lobular breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "The co-existence of ductal and lobular carcinoma in situ in the breast, without evidence of stromal invasion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006184"
    }
  ],
  "roots": [
    {
      "id": 6433,
      "label": "in situ carcinoma"
    },
    {
      "id": 6730,
      "label": "breast carcinoma"
    }
  ]
}