{
  "id": 6454,
  "label": "lupus erythematosus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004670",
  "properties": {
    "xrefs": [
      "DOID:8857",
      "ICD10CM:L93",
      "ICD10WHO:L93",
      "ICD9:695.4",
      "MEDGEN:98043",
      "NCIT:C27153",
      "SCTID:200936003",
      "UMLS:C0409974",
      "icd11.foundation:1443317238"
    ],
    "synonyms": [
      "lupus",
      "lupus erythematosus"
    ],
    "categories": [
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "An autoimmune, connective tissue chronic inflammatory disorder affecting the skin, joints, kidneys, lungs, heart, and the peripheral blood cells. It is more commonly seen in women than men. Variants include discoid and systemic lupus erythematosus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7203,
      "label": "rheumatic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1575",
          "EFO:0005755",
          "ICD9:729.0",
          "MEDGEN:3157",
          "MESH:D012216",
          "NANDO:2100151",
          "NANDO:2100152",
          "NCIT:C27204",
          "SCTID:396332003",
          "UMLS:C0009326",
          "Wikipedia:Rheumatism"
        ],
        "synonyms": [
          "rheumatic disease",
          "rheumatologic disorder",
          "collagen disease",
          "collagen vascular disease",
          "connective tissue disease",
          "disease, rheumatic",
          "diseases, rheumatic",
          "enthesopathies",
          "enthesopathy",
          "inflammatory rheumatism",
          "musculoskeletal pain disorder",
          "rheumatism"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Inflammatory and degenerative diseases of connective tissue structures, such as arthritis."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005554"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 6978,
      "label": "cutaneous lupus erythematosus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050169",
          "EFO:0003834",
          "GARD:0006225",
          "MEDGEN:7401",
          "MESH:D008178",
          "NCIT:C26819",
          "SCTID:7119001",
          "UMLS:C0024137",
          "icd11.foundation:1401395930"
        ],
        "synonyms": [
          "lupus erythematosus, cutaneous"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune disorder that manifests as different lupus-specific skin disorders; it can occur with systemic lupus erythematosus, or as a singular disease."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005282"
    },
    {
      "id": 9248,
      "label": "systemic lupus erythematosus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6454,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9074",
          "HP:0002725",
          "ICD10CM:M32",
          "ICD10WHO:M32",
          "ICD9:710.0",
          "MEDGEN:6146",
          "MESH:D008180",
          "NANDO:1200272",
          "NANDO:2200416",
          "NCIT:C3201",
          "NORD:1380",
          "OMIM:152700",
          "OMIMPS:601744",
          "Orphanet:536",
          "SCTID:55464009",
          "UMLS:C0024141",
          "icd11.foundation:749596428"
        ],
        "synonyms": [
          "Lupus",
          "SLE",
          "SLE - lupus erythematosus, systemic",
          "disseminated lupus erythematosus",
          "lupus erythematosus, systemic",
          "systemic lupus erythematosus",
          "systemic lupus erythematosus (disease)",
          "systemic lupus erythematosus susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific."
      },
      "child_count": 20,
      "reference_id": "MONDO:0007915"
    },
    {
      "id": 16984,
      "label": "drug-induced lupus erythematosus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0040093",
          "GARD:0020599",
          "MEDGEN:537988",
          "MedDRA:10013706",
          "NCIT:C114354",
          "Orphanet:231111",
          "SCTID:80258006",
          "UMLS:C0263591",
          "icd11.foundation:1239818910"
        ],
        "synonyms": [
          "DIL",
          "DILE",
          "drug induced lupus",
          "drug induced lupus erythematosus",
          "drug-induced lupus"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune disorder, similar to systemic lupus erythematosus, that is caused by certain drugs."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016474"
    }
  ],
  "roots": [
    {
      "id": 7203,
      "label": "rheumatic disorder"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}