{
  "id": 6473,
  "label": "squamous carcinoma in situ",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004693",
  "properties": {
    "xrefs": [
      "ICDO:8070/2",
      "ICDO:8077/2",
      "MEDGEN:83116",
      "NCIT:C27093",
      "UMLS:C0334245"
    ],
    "synonyms": [
      "carcinoma, squamous cell, in situ, malignant",
      "epidermoid carcinoma in situ",
      "epidermoid cell carcinoma in situ",
      "grade 3 SIN",
      "grade 3 squamous intraepithelial neoplasia",
      "grade III SIN",
      "grade III squamous intraepithelial neoplasia",
      "intraepithelial squamous cell carcinoma",
      "squamous carcinoma in situ",
      "squamous cell carcinoma in situ",
      "squamous cell carcinoma in-situ",
      "stage 0 squamous cell carcinoma",
      "CIN III",
      "CIN III - carcinoma in situ of cervix",
      "CIN III - severe dyskaryosis",
      "carcinoma in situ of cervix",
      "carcinoma in situ of uterine cervix",
      "cervical intraepithelial neoplasia grade III with severe dysplasia",
      "cervix Ca in situ",
      "severe dysplasia of cervix",
      "severe dysplasia of the cervix uteri",
      "squamous intraepithelial neoplasia, grade III",
      "stage 0 uterine cervix carcinoma",
      "uterine cervix in situ carcinoma"
    ],
    "definition": "A malignant epithelial neoplasm confined to the squamous epithelium, without invasion of the underlying tissues."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6433,
      "label": "in situ carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20078,
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8719",
          "ICD9:230-234",
          "ICD9:234.8",
          "ICD9:234.9",
          "ICDO:8010/2",
          "MEDGEN:763",
          "MESH:D002278",
          "NCIT:C2917",
          "SCTID:109355002",
          "UMLS:C0007099"
        ],
        "synonyms": [
          "CIS",
          "carcinoma in situ",
          "carcinoma, in situ, malignant",
          "epithelial tumor, in situ, malignant",
          "intraepithelial carcinoma",
          "non-invasive carcinoma",
          "stage 0 disease"
        ],
        "definition": "A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion."
      },
      "child_count": 63,
      "reference_id": "MONDO:0004647"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    }
  ],
  "children": [
    {
      "id": 6445,
      "label": "trachea carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3640,
        6473
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8802",
          "ICD10CM:D02.1",
          "ICD9:231.1",
          "MEDGEN:57816",
          "NCIT:C3639",
          "SCTID:92772005",
          "UMLS:C0154070"
        ],
        "synonyms": [
          "carcinoma in situ of the trachea",
          "carcinoma in situ of trachea",
          "severe epithelial dysplasia of trachea",
          "stage 0 trachea carcinoma",
          "trachea carcinoma in situ",
          "trachea in situ carcinoma",
          "tracheal carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the tracheal mucosa and is confined to the epithelial layer without evidence of further tissue invasion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004661"
    },
    {
      "id": 6455,
      "label": "penis carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6473,
        18435
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8872",
          "GARD:0024082",
          "ICD10CM:D07.4",
          "ICD9:233.5",
          "ICDO:8080/2",
          "MEDGEN:102309",
          "NCIT:C27790",
          "SCTID:398831006",
          "UMLS:C0154089"
        ],
        "synonyms": [
          "Bowen disease of the penis",
          "Bowen's disease of penis",
          "Bowen's disease of the penis",
          "Queyrat erythroplasia",
          "Queyrat's erythroplasia",
          "carcinoma in situ of penis",
          "carcinoma in situ of the penis",
          "erythroplasia of Queyrat",
          "grade III penile intraepithelial neoplasia",
          "grade III squamous intraepithelial lesion of penis",
          "grade III squamous intraepithelial lesion of the penis",
          "penile carcinoma in situ",
          "penile carcinoma in situ aJCC v7",
          "penis in situ carcinoma",
          "stage 0 penile carcinoma in situ",
          "stage 0 penis carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the penis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004671"
    },
    {
      "id": 20161,
      "label": "skin squamous cell carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4598,
        6427,
        6473
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:378389",
          "NCIT:C2906",
          "UMLS:C2314897"
        ],
        "synonyms": [
          "intraepidermal squamous cell carcinoma",
          "skin squamous cell cancer in situ",
          "skin squamous cell carcinoma in situ",
          "squamous cell carcinoma in situ of skin",
          "squamous cell carcinoma in situ of the skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Intraepidermal squamous cell carcinoma, confined to the epidermis. There is no evidence of invasion."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020760"
    }
  ],
  "roots": [
    {
      "id": 6433,
      "label": "in situ carcinoma"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    }
  ]
}