{
  "id": 6477,
  "label": "esophageal leukoplakia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004697",
  "properties": {
    "xrefs": [
      "DOID:9021",
      "HP:0012859",
      "ICD9:530.83",
      "MEDGEN:75628",
      "NCIT:C3953",
      "SCTID:89057003",
      "UMLS:C0267095"
    ],
    "synonyms": [
      "esophageal epidermoid metaplasia",
      "esophageal leukoplakia",
      "esophageal leukoplakia (disease)",
      "esophagus leukoplakia",
      "leukoplakia of esophagus",
      "leukoplakia of oesophagus",
      "leukoplakia of the esophagus",
      "leukoplakia of the oesophagus",
      "oesophagus leukoplakia"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A rare condition that usually affects the middle-to-distal esophagus in middle-aged and elderly people. There is usually a history of tobacco smoking or alcohol intake. Dysphagia is the presenting symptom. Morphologically, the lesions are well-demarcated and are characterized by epithelial hyperplasia, thickened basal layer, prominent granular cell layer, and hyperorthokeratosis. In a minority of patients this condition is associated with adjacent high-grade squamous dysplasia and/or squamous cell carcinoma."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5629,
      "label": "esophageal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23495
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6050",
          "EFO:0009544",
          "ICD9:530",
          "ICD9:530.2",
          "ICD9:530.20",
          "ICD9:530.9",
          "MEDGEN:8693",
          "MESH:D004935",
          "NCIT:C3027",
          "SCTID:30811009",
          "SCTID:37657006",
          "UMLS:C0014852",
          "icd11.foundation:1594312948"
        ],
        "synonyms": [
          "disease of esophagus",
          "disease of oesophagus",
          "disease or disorder of esophagus",
          "disease or disorder of oesophagus",
          "disorder of esophagus",
          "disorder of oesophagus",
          "esophageal disorder",
          "esophagus disease",
          "esophagus disease or disorder",
          "oesophagus disease",
          "oesophagus disease or disorder",
          "esophageal ulcer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003749"
    },
    {
      "id": 23173,
      "label": "leukoplakia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:44133",
          "MESH:D007971",
          "NCIT:C3186",
          "SCTID:274134003",
          "UMLS:C0023531"
        ],
        "synonyms": [
          "keratotic plaque",
          "leukoplakia",
          "lesion, leukoplakic",
          "lesions, leukoplakic",
          "leukokeratoses",
          "leukokeratosis",
          "leukoplakias",
          "leukoplakic lesion",
          "leukoplakic lesions"
        ],
        "definition": "A white patch or plaque on a mucous membrane that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc., must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition."
      },
      "child_count": 5,
      "reference_id": "MONDO:0043243"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5629,
      "label": "esophageal disorder"
    },
    {
      "id": 23173,
      "label": "leukoplakia"
    }
  ]
}