{
  "id": 6487,
  "label": "esophagus carcinoma in situ",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004708",
  "properties": {
    "xrefs": [
      "DOID:9095",
      "GARD:0024094",
      "ICD10CM:D00.1",
      "ICD9:230.1",
      "MEDGEN:56332",
      "NCIT:C89771",
      "SCTID:92585006",
      "UMLS:C0154059",
      "icd11.foundation:218644880"
    ],
    "synonyms": [
      "carcinoma in situ of esophagus",
      "carcinoma in situ of oesophagus",
      "esophageal carcinoma in situ",
      "esophageal carcinoma in situ aJCC v7",
      "esophagus in situ carcinoma",
      "oesophagus in situ carcinoma",
      "severe esophageal dysplasia",
      "severe esophageal dysplasia aJCC v7",
      "stage 0 esophageal cancer",
      "stage 0 esophageal cancer aJCC v7",
      "stage 0 esophageal carcinoma in situ",
      "stage 0 esophagus carcinoma",
      "stage 0 oesophagus carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Stage 0 includes: For squamous cell carcinoma: Tis (HGD), N0, M0, G1, GX, Tumor location: Any. For adenocarcinoma: Tis (HGD), N0, M0, G1, GX. Tis: High-grade dysplasia. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated. GX: Grade cannot be assessed-stage grouping as G1. Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. (AJCC 7th ed.)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6433,
      "label": "in situ carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20078,
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8719",
          "ICD9:230-234",
          "ICD9:234.8",
          "ICD9:234.9",
          "ICDO:8010/2",
          "MEDGEN:763",
          "MESH:D002278",
          "NCIT:C2917",
          "SCTID:109355002",
          "UMLS:C0007099"
        ],
        "synonyms": [
          "CIS",
          "carcinoma in situ",
          "carcinoma, in situ, malignant",
          "epithelial tumor, in situ, malignant",
          "intraepithelial carcinoma",
          "non-invasive carcinoma",
          "stage 0 disease"
        ],
        "definition": "A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion."
      },
      "child_count": 63,
      "reference_id": "MONDO:0004647"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7738,
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1107",
          "EFO:0002916",
          "GARD:0006383",
          "MEDGEN:56256",
          "MedDRA:10030155",
          "NCIT:C3513",
          "Orphanet:70482",
          "SCTID:372138000",
          "UMLS:C0152018"
        ],
        "synonyms": [
          "Esophageal cancer",
          "carcinoma of esophagus",
          "carcinoma of the esophagus",
          "carcinoma of the oesophagus",
          "esophageal carcinoma",
          "esophagus carcinoma",
          "oesophagus carcinoma",
          "cancer of esophagus",
          "cancer of oesophagus",
          "cancer of the esophagus",
          "cancer of the oesophagus",
          "esophageal cancer",
          "esophageal cancer, NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0019086"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6433,
      "label": "in situ carcinoma"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus"
    }
  ]
}