{
  "id": 6507,
  "label": "central sleep apnea syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004731",
  "properties": {
    "xrefs": [
      "DOID:9220",
      "MEDGEN:854402",
      "MESH:D020182",
      "NCIT:C27169",
      "SCTID:27405005",
      "UMLS:C3887547"
    ],
    "synonyms": [
      "central sleep apnea syndrome",
      "central sleep apnea, primary",
      "primary central sleep apnea",
      "secondary central sleep apnea",
      "Apneas, central",
      "Apneas, central sleep",
      "Breathings, central sleep-disordered",
      "alveolar hypoventilation, central",
      "alveolar hypoventilations, central",
      "apnea, central",
      "apnea, central sleep",
      "apnea, sleep, central",
      "breathing, central sleep-disordered",
      "central Apneas",
      "central alveolar hypoventilation",
      "central alveolar hypoventilation syndrome",
      "central apnea",
      "central sleep Apneas",
      "central sleep apnea",
      "central sleep apnea, secondary",
      "central sleep disordered breathing",
      "central sleep-disordered Breathings",
      "central sleep-disordered breathing",
      "hypoventilation, central alveolar",
      "hypoventilations, central alveolar",
      "ondine syndrome",
      "sleep Apneas, central",
      "sleep apnea, lethal central",
      "sleep disordered breathing, central",
      "sleep-disordered Breathings, central",
      "sleep-disordered breathing, central"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 6990,
      "label": "sleep apnea syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5338,
        6815
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050847",
          "EFO:0003877",
          "HP:0010535",
          "ICD10CM:G47.3",
          "ICD9:780.57",
          "MEDGEN:11458",
          "MESH:D012891",
          "NCIT:C148023",
          "SCTID:111489007",
          "SCTID:73430006",
          "UMLS:C0037315"
        ],
        "synonyms": [
          "breathing-related sleep disorder",
          "SDB",
          "sleep apnea",
          "sleep apnea syndrome",
          "sleep apneas",
          "sleep disordered breathing",
          "sleep-disordered breathing",
          "apnea syndrome, sleep",
          "apnea syndromes, sleep",
          "apnea, sleep",
          "apneas, sleep",
          "breathing, sleep-disordered",
          "hypersomnia with periodic respiration",
          "hypopnea, sleep",
          "hypopneas, sleep",
          "mixed central and obstructive sleep apnea",
          "mixed sleep Apneas",
          "mixed sleep apnea",
          "sleep apnea, mixed",
          "sleep apnea, mixed central and obstructive",
          "sleep apneas, mixed",
          "sleep hypopnea",
          "sleep hypopneas"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005296"
    }
  ],
  "children": [
    {
      "id": 21379,
      "label": "primary central sleep apnea syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:G47.31",
          "ICD9:327.21",
          "MEDGEN:148385",
          "SCTID:9741000119101",
          "UMLS:C0751762"
        ],
        "synonyms": [
          "primary central sleep apnea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A central sleep apnea syndrome considered to be idiopathic. Central sleep apnea is caused by improper signaling from the brainstem to the respiratory muscles and is triggered by either hypoventilation or hyperventilation. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating, and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024356"
    },
    {
      "id": 21380,
      "label": "drug induced central sleep apnea",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:783188",
          "SCTID:104831000119109",
          "UMLS:C3662033"
        ],
        "synonyms": [
          "drug induced central sleep apnea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A central sleep apnea syndrome induced by medication or substance use. Central sleep apnea is caused by improper signaling from the brainstem to the respiratory muscles and is triggered by either hypoventilation or hyperventilation. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating, and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024357"
    },
    {
      "id": 21381,
      "label": "complex sleep apnea",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6507,
        8555
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080302",
          "MEDGEN:83271",
          "SCTID:230493001",
          "UMLS:C0338495"
        ],
        "synonyms": [
          "CompSAS",
          "complex sleep apnea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A distinct form of sleep-disordered breathing characterized as central sleep apnea (CSA), and presents in obstructive sleep apnea (OSA) patients during initial treatment with a continuous positive airway pressure (CPAP) device."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024358"
    },
    {
      "id": 21382,
      "label": "central sleep apnea due to periodic breathing",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:327.27",
          "ICD9:786.09",
          "MEDGEN:783212",
          "SCTID:85721000119105",
          "UMLS:C3662057"
        ],
        "synonyms": [
          "central sleep apnea due to periodic breathing",
          "Cheyne–Stokes breathing",
          "central sleep apnea with Cheyne–Stokes breathing"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A sleep-related disorder characterized by cyclical breathing patterns where periods of shallow or absent breathing (apneas or hypopneas) alternate with periods of deeper breathing (hyperpnea). This cyclical pattern is caused by an instability in the body's respiratory control system, where the brain doesn't properly regulate breathing effort."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024359"
    },
    {
      "id": 21383,
      "label": "central sleep apnea caused by high altitude",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:884045",
          "SCTID:91441000119109",
          "UMLS:C4075997"
        ],
        "synonyms": [
          "central sleep apnea due to high altitude",
          "central sleep apnea due to high-altitude periodic breathing",
          "high altitude-induced periodic breathing"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A central sleep apnea syndrome induced by sleeping at an altitude higher than 2000 m. Central sleep apnea is caused by improper signaling from the brainstem to the respiratory muscles and is triggered by either hypoventilation or hyperventilation. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating, and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024360"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 6990,
      "label": "sleep apnea syndrome"
    }
  ]
}