{
  "id": 6576,
  "label": "osteosclerotic plasma cell myeloma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004815",
  "properties": {
    "xrefs": [
      "DOID:9541",
      "GARD:0024111",
      "MEDGEN:857662",
      "NCIT:C7765",
      "SCTID:425657001",
      "UMLS:C3898068"
    ],
    "synonyms": [
      "osteosclerotic multiple myeloma",
      "osteosclerotic plasma cell myeloma",
      "osteosclerotic myeloma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A plasma cell neoplasm associated with osteosclerotic and fibrotic changes in the bone trabeculae. Often, the lymph nodes show changes resembling the plasma cell variant of Castleman disease. It is often part of POEMS syndrome which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 10907,
      "label": "plasma cell myeloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6702,
        6892
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9538",
          "EFO:0001378",
          "GARD:0007108",
          "ICD10CM:C90.0",
          "ICD9:203.0",
          "ICDO:9732/3",
          "MEDGEN:10122",
          "MESH:D009101",
          "MedDRA:10028228",
          "NCIT:C3242",
          "NORD:1469",
          "OMIM:254500",
          "ONCOTREE:PCM",
          "Orphanet:29073",
          "UMLS:C0026764",
          "icd11.foundation:1582389689",
          "icd11.foundation:526287100"
        ],
        "synonyms": [
          "Kahler disease",
          "Kahler's disease",
          "Multiple Myeloma",
          "medullary plasmacytoma",
          "multiple myeloma",
          "multiple myeloma, resistance to, Somatic mutation",
          "multiple myeloma, susceptibility to, Somatic mutation",
          "multiple myeloma/plasma cell myeloma",
          "myeloid neoplasm of plasma cell",
          "myeloma",
          "myeloma, multiple",
          "myeloma, plasma cell, malignant",
          "myelomatosis",
          "plasma cell myeloid neoplasm",
          "plasma cell myeloma",
          "Al amyloidosis",
          "amyloidosis, systemic",
          "myeloma - multiple"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)"
      },
      "child_count": 9,
      "reference_id": "MONDO:0009693"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 10907,
      "label": "plasma cell myeloma"
    }
  ]
}