{
  "id": 6578,
  "label": "non-secretory plasma cell myeloma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004817",
  "properties": {
    "xrefs": [
      "DOID:9547",
      "GARD:0024113",
      "MEDGEN:857719",
      "NCIT:C4734",
      "SCTID:277580004",
      "UMLS:C3898125"
    ],
    "synonyms": [
      "non-secretory multiple myeloma",
      "non-secretory plasma cell myeloma",
      "non-functioning myeloma",
      "non-secreting myeloma",
      "non-secretory myeloma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare type of multiple myeloma in which the plasma cells synthesize but do not secrete immunoglobulins. As a result, none of the immunoglobulins appear out of the normal range. The symptoms are generally the same with those of immunoglobulin-secreting myeloma; however, the incidence of renal insufficiency is lower in non-secretory myeloma. The diagnosis can be missed because of the absence of monoclonal immunoglobulin in the serum or urine."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 10907,
      "label": "plasma cell myeloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6702,
        6892
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9538",
          "EFO:0001378",
          "GARD:0007108",
          "ICD10CM:C90.0",
          "ICD9:203.0",
          "ICDO:9732/3",
          "MEDGEN:10122",
          "MESH:D009101",
          "MedDRA:10028228",
          "NCIT:C3242",
          "NORD:1469",
          "OMIM:254500",
          "ONCOTREE:PCM",
          "Orphanet:29073",
          "UMLS:C0026764",
          "icd11.foundation:1582389689",
          "icd11.foundation:526287100"
        ],
        "synonyms": [
          "Kahler disease",
          "Kahler's disease",
          "Multiple Myeloma",
          "medullary plasmacytoma",
          "multiple myeloma",
          "multiple myeloma, resistance to, Somatic mutation",
          "multiple myeloma, susceptibility to, Somatic mutation",
          "multiple myeloma/plasma cell myeloma",
          "myeloid neoplasm of plasma cell",
          "myeloma",
          "myeloma, multiple",
          "myeloma, plasma cell, malignant",
          "myelomatosis",
          "plasma cell myeloid neoplasm",
          "plasma cell myeloma",
          "Al amyloidosis",
          "amyloidosis, systemic",
          "myeloma - multiple"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)"
      },
      "child_count": 9,
      "reference_id": "MONDO:0009693"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 10907,
      "label": "plasma cell myeloma"
    }
  ]
}