{
  "id": 6606,
  "label": "pulmonary emphysema",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004849",
  "properties": {
    "xrefs": [
      "DOID:9675",
      "EFO:0000464",
      "ICD10CM:J43",
      "ICD9:492",
      "ICD9:492.8",
      "MEDGEN:18764",
      "MESH:D004646",
      "MESH:D011656",
      "NCIT:C3348",
      "SCTID:87433001",
      "UMLS:C0034067"
    ],
    "synonyms": [
      "emphysema",
      "emphysema, pulmonary"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A subcategory of chronic obstructive pulmonary disease (COPD). It occurs in people who smoke and suffer from chronic bronchitis. It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6740,
      "label": "chronic obstructive pulmonary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4382,
        4630
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3083",
          "EFO:0000341",
          "ICD9:490-496",
          "ICD9:496",
          "MEDGEN:9818",
          "MESH:D029424",
          "NCIT:C3199",
          "OMIM:606963",
          "SCTID:13645005",
          "UMLS:C0024117",
          "icd11.foundation:133207228"
        ],
        "synonyms": [
          "COLD",
          "COPD",
          "COPD, chronic obstructive pulmonary disease",
          "chronic obstructive airways disease",
          "chronic obstructive lung disease",
          "chronic obstructive pulmonary disease (COPD)",
          "chronic obstructive pulmonary disease, (COPD)",
          "cold",
          "cold (chronic obstructive lung disease)",
          "disease (COPD), chronic obstructive",
          "obstructive lung disease, chronic",
          "obstructive pulmonary disease (COPD), chronic",
          "pulmonary disease (COPD), chronic obstructive"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005002"
    }
  ],
  "children": [
    {
      "id": 3193,
      "label": "interstitial emphysema",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10030",
          "ICD10CM:J98.2",
          "ICD9:518.1",
          "MEDGEN:234586",
          "NCIT:C34571",
          "SCTID:77690003",
          "UMLS:C1370824",
          "icd11.foundation:2008095771"
        ],
        "synonyms": [
          "PIE",
          "interstitial emphysema of lung",
          "pie",
          "pulmonary interstitial emphysema"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Pathologic accumulation of air in the interstitium of the lungs, which is caused by the rupture of alveoli and terminal bronchioles, and is most often seen in premature infants that need mechanical ventilation for respiratory distress syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000923"
    },
    {
      "id": 3194,
      "label": "compensatory emphysema",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10031",
          "ICD10CM:J98.3",
          "ICD9:518.2",
          "MEDGEN:510136",
          "SCTID:33325001",
          "UMLS:C0155918",
          "icd11.foundation:318427535"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0000924"
    },
    {
      "id": 3195,
      "label": "hyperlucent lung",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10032",
          "MEDGEN:101178",
          "MESH:D019568",
          "UMLS:C0524799"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung with reduced markings on its chest radiograph and increased areas of transradiancy (hyperlucency). A hyperlucent lung is usually associated with pulmonary emphysema or pneumothorax."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000925"
    },
    {
      "id": 8916,
      "label": "emphysema, hereditary pulmonary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:502241",
          "MESH:C565057",
          "OMIM:130700",
          "UMLS:C3501835"
        ],
        "synonyms": [
          "emphysema, hereditary pulmonary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007535"
    },
    {
      "id": 8917,
      "label": "congenital lobar emphysema",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002104",
          "MEDGEN:120557",
          "MESH:C535735",
          "MedDRA:10010456",
          "NCIT:C98895",
          "NORD:1085",
          "OMIM:130710",
          "Orphanet:1928",
          "SCTID:66987001",
          "UMLS:C0265797",
          "icd11.foundation:685349915"
        ],
        "synonyms": [
          "CLE",
          "Emphysema, Congenital Lobar",
          "congenital lobar hyperinflation",
          "emphysema, congenital lobar",
          "infantile lobar hyperinflation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Congenital lobar emphysema (CLE) is a respiratory abnormality characterized by respiratory distress due to hyperinflation of one or more affected lobes of the lung."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007536"
    }
  ],
  "roots": [
    {
      "id": 6740,
      "label": "chronic obstructive pulmonary disease"
    }
  ]
}