{
  "id": 6624,
  "label": "biliary tract disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004868",
  "properties": {
    "xrefs": [
      "DOID:9741",
      "EFO:0009534",
      "ICD9:576.9",
      "MEDGEN:108201",
      "MESH:D001660",
      "SCTID:105997008",
      "UMLS:C0549613"
    ],
    "synonyms": [
      "biliary tree disease",
      "biliary tree disease or disorder",
      "disease of biliary tree",
      "disease or disorder of biliary tree",
      "disorder of biliary tree"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A disease involving the biliary tree."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 15,
  "parents": [
    {
      "id": 4586,
      "label": "hepatobiliary disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3118",
          "EFO:0010284",
          "MEDGEN:82758",
          "NCIT:C3959",
          "UMLS:C0267792"
        ],
        "synonyms": [
          "disease of hepatobiliary system",
          "disease or disorder of hepatobiliary system",
          "disorder of hepatobiliary system",
          "hepatobiliary disorder",
          "hepatobiliary system disease",
          "hepatobiliary system disease or disorder",
          "liver and biliary disease",
          "liver and biliary disorder",
          "liver and biliary system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002515"
    }
  ],
  "children": [
    {
      "id": 4900,
      "label": "bile duct disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4138",
          "MEDGEN:2240",
          "MESH:D001649",
          "NCIT:C96716",
          "SCTID:118926004",
          "UMLS:C0005395"
        ],
        "synonyms": [
          "bile duct disease",
          "bile duct disease or disorder",
          "bile duct disorder",
          "disease of bile duct",
          "disease or disorder of bile duct",
          "disorder of bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disease involving the bile duct."
      },
      "child_count": 7,
      "reference_id": "MONDO:0002887"
    },
    {
      "id": 6998,
      "label": "biliary tract neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6624,
        21432
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050625",
          "EFO:0003891",
          "HP:0100574",
          "MEDGEN:14118",
          "ONCOTREE:BILIARY_TRACT",
          "SCTID:126853008",
          "UMLS:C0005426"
        ],
        "synonyms": [
          "biliary tract neoplasm",
          "biliary tract neoplasm (disease)",
          "biliary tree neoplasm",
          "biliary tree neoplasm (disease)",
          "biliary tree tumor",
          "biliary tree tumour",
          "neoplasm of biliary tree",
          "tumor of biliary tree",
          "tumour of biliary tree",
          "BILIARY_TRACT",
          "tumour of the extrahepatic bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm that involves the biliary tract."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005304"
    },
    {
      "id": 7031,
      "label": "gallstones",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004210",
          "ICD9:574.20",
          "MEDGEN:66850",
          "MESH:D042882",
          "SCTID:235919008",
          "UMLS:C0242216"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Solid crystalline precipitates in the biliary tract, usually formed in the gallbladder, resulting in the condition of cholelithiasis. Gallstones, derived from the bile, consist mainly of calcium, cholesterol, or bilirubin."
      },
      "child_count": 1,
      "reference_id": "MONDO:0005346"
    },
    {
      "id": 7068,
      "label": "primary biliary cholangitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6624,
        8725
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12236",
          "EFO:1001486",
          "GARD:0007459",
          "ICD10CM:K74.3",
          "ICD9:571.6",
          "MEDGEN:3035",
          "MESH:D008105",
          "MedDRA:10004661",
          "MedDRA:10019137",
          "NANDO:1200439",
          "NCIT:C27167",
          "NORD:1604",
          "OMIMPS:109720",
          "Orphanet:186",
          "SCTID:31712002",
          "UMLS:C0008312",
          "icd11.foundation:649193479"
        ],
        "synonyms": [
          "Hanot syndrome",
          "PBC",
          "chronic non-suppurative destructive cholangitis",
          "chronic nonsuppurative destructive cholangitis",
          "primary Bilary cirrhosis (PBC)",
          "primary biliary cirrhosis",
          "biliary cirrhosis, primary",
          "familial primary biliary cirrhosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005388"
    },
    {
      "id": 8144,
      "label": "bile reflux",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12237",
          "EFO:1000838",
          "MEDGEN:2243",
          "MESH:D001655",
          "UMLS:C0005403"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (duodenogastric reflux); to the esophagus (gastroesophageal reflux); or to the pancreas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006677"
    },
    {
      "id": 8349,
      "label": "postcholecystectomy syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624,
        7612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9740",
          "EFO:1001117",
          "ICD10CM:K91.5",
          "ICD9:576.0",
          "MEDGEN:101815",
          "MESH:D017562",
          "SCTID:90782003",
          "UMLS:C0152099",
          "icd11.foundation:157319976"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Abdominal symptoms after removal of the gallbladder. The common postoperative symptoms are often the same as those present before the operation, such as colic, bloating, nausea, and vomiting. There is pain on palpation of the right upper quadrant and sometimes jaundice. The term is often used, inaccurately, to describe such postoperative symptoms not due to gallbladder removal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006916"
    },
    {
      "id": 8716,
      "label": "Alagille syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        6624,
        7019,
        16089,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9245",
          "GARD:0000804",
          "ICD9:759.89",
          "MEDGEN:39014",
          "MESH:D016738",
          "MedDRA:10053870",
          "NANDO:1200918",
          "NANDO:1200919",
          "NANDO:2200931",
          "NCIT:C35139",
          "NORD:748",
          "OMIMPS:118450",
          "Orphanet:52",
          "SCTID:31742004",
          "UMLS:C0085280",
          "icd11.foundation:1249656206"
        ],
        "synonyms": [
          "Alagille syndrome",
          "Alagille-Watson syndrome",
          "Arteriohepatic dysplasia",
          "syndromic bile duct paucity",
          "Cardiovertebral syndrome",
          "Hepatofacioneurocardiovertebral syndrome",
          "Watson Alagille syndrome",
          "Watson-Miller syndrome",
          "hepatic ductular hypoplasia",
          "paucity of interlobular bile ducts"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Alagille (AGS) syndrome is variably characterized by chronic cholestasis due to paucity of intrahepatic bile ducts, peripheral pulmonary artery stenosis, vertebrae segmentation anomalies, characteristic facies, posterior embryotoxon/anterior segment abnormalities, pigmentary retinopathy, and dysplastic kidneys."
      },
      "child_count": 15,
      "reference_id": "MONDO:0007318"
    },
    {
      "id": 9005,
      "label": "isolated agenesis of gallbladder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021844",
          "MEDGEN:82736",
          "MESH:C562564",
          "OMIM:137040",
          "Orphanet:440987",
          "UMLS:C0266251"
        ],
        "synonyms": [
          "gallbladder, agenesis OF"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007642"
    },
    {
      "id": 13712,
      "label": "cholelithiasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10211",
          "EFO:0004799",
          "ICD10CM:K80",
          "ICD10WHO:K80",
          "ICD9:574",
          "ICD9:574.20",
          "ICD9:574.5",
          "MEDGEN:3039",
          "MESH:D002769",
          "NCIT:C122822",
          "SCTID:266474003",
          "UMLS:C0008350",
          "icd11.foundation:1268183934"
        ],
        "synonyms": [
          "gallstones"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "The presence of crystallized deposits forming in the gallbladder or biliary tree, primarily composed of cholesterol, bilirubin, and bile."
      },
      "child_count": 4,
      "reference_id": "MONDO:0012672"
    },
    {
      "id": 17702,
      "label": "ketamine-induced biliary dilatation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624,
        21773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1380193",
          "Orphanet:293807",
          "SCTID:726613003",
          "UMLS:C4512018"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Ketamine-induced biliary dilatation is an acquired biliary tract disease caused by the abusive consumption of ketamine, which results in the fusiform dilatation of the common bile ducts (CBD) without obstructive lesions or dilatation of the intrahepatic biliary ducts. Possible manifestations of the underlying cholangiopathy include epigastric pain and impaired liver function. Severity of CBD dilatation appears to correlate with the duration of ketamine consumption and the condition has been reported to be reversible in abstinent patients."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017394"
    },
    {
      "id": 17869,
      "label": "follicular cholangitis and pancreatitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4455,
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021236",
          "MEDGEN:1667817",
          "Orphanet:300552",
          "UMLS:C4749906"
        ],
        "synonyms": [
          "follicular pancreatocholangitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Follicular cholangitis and pancreatitis is a rare pancreatobiliary disease characterized by marked duct-centered lymphoid follicular inflammation that develops in both biliary and pancreatic ductal systems, mainly affecting the hilar bile ducts and the pancreatic head. Patients present with jaundice, abdominal pain, liver dysfunction, pruritus and/or weight loss. Histology shows lymphoplasmacytic infiltration with formation of numerous, large lymphpoid follicles around the affected bile and pancreatic ducts."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017589"
    },
    {
      "id": 18752,
      "label": "idiopathic ductopenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021975",
          "MEDGEN:1814697",
          "Orphanet:480512",
          "UMLS:C5702661"
        ],
        "synonyms": [
          "IAD",
          "idiopathic adult ductopenia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018807"
    },
    {
      "id": 18753,
      "label": "Caroli syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        5714,
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081394",
          "GARD:0021976",
          "MEDGEN:1814547",
          "NANDO:2200934",
          "Orphanet:480520",
          "UMLS:C5700203"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare genetic hepatic disease characterized by multiple segmental cystic dilatations of both central and smaller peripheral bile ducts associated with congenital hepatic fibrosis. Age of symptom onset is variable, as is disease progression. Patients present with recurrent cholangitis, hepatolithiasis, and cholecystolithiasis. Portal hypertension may appear later in the disease course, and the risk of developing cholangiocarcinoma is increased significantly. The syndrome is often associated with autosomal recessive polycystic kidney disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018808"
    },
    {
      "id": 18776,
      "label": "isolated congenital hepatic fibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624,
        8725
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021995",
          "ICD9:777.8",
          "MEDGEN:40449",
          "MESH:C562378",
          "NANDO:2100267",
          "NANDO:2200936",
          "NCIT:C97071",
          "NORD:1225",
          "Orphanet:485426",
          "SCTID:79607001",
          "UMLS:C0009714"
        ],
        "synonyms": [
          "isolated CHF",
          "Congenital Hepatic Fibrosis",
          "congenital hepatic fibrosis",
          "nonsyndromic congenital hepatic fibrosis",
          "congenital fibrose liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A congenital disorder usually inherited in an autosomal recessive pattern. It affects the hepatobiliary system and the kidneys. It is characterized by liver fibrosis, portal hypertension, and renal cysts."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018840"
    },
    {
      "id": 23185,
      "label": "Rokitansky-Aschoff sinuses of the gallbladder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624,
        6977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:78636",
          "MESH:C535869",
          "SCTID:22149007",
          "UMLS:C0267892"
        ],
        "synonyms": [
          "Aschoff-Rokitansky sinuses",
          "Rokitansky-Aschoff sinuses",
          "intramural diverticulosis of the gallbladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An abnormality characterized by macroscopic or microscopic outpouchings of gallbladder mucosa into the muscle of the gallbladder wall. It may be associated with cholecystitis or gallstones."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043291"
    }
  ],
  "roots": [
    {
      "id": 4586,
      "label": "hepatobiliary disorder"
    }
  ]
}