{
  "id": 6687,
  "label": "eosinophilia-myalgia syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004941",
  "properties": {
    "xrefs": [
      "DOID:998",
      "EFO:1001316",
      "GARD:0006345",
      "ICD9:710.5",
      "MEDGEN:38987",
      "MESH:D016603",
      "NORD:1094",
      "SCTID:95416007",
      "UMLS:C0085179",
      "icd11.foundation:1361333197"
    ],
    "synonyms": [
      "eosinophilia myalgia syndrome",
      "EMS",
      "L-tryptophan induced EMS",
      "severe muscle pain and abnormally high eosinophils",
      "syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include eosinophilia, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn wd, Semin Arthritis Rheum 1997 Jun;26(6):788-93)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16456,
      "label": "hypereosinophilic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        16883,
        23489
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:999",
          "EFO:1001467",
          "GARD:0002804",
          "ICD10CM:D72.11",
          "ICD9:288.3",
          "ICDO:9964/3",
          "MEDGEN:280990",
          "MESH:D017681",
          "MedDRA:10048643",
          "NANDO:2200805",
          "NANDO:2200806",
          "NCIT:C27038",
          "Orphanet:168956",
          "SCTID:419455006",
          "UMLS:C1540912",
          "icd11.foundation:110429919"
        ],
        "synonyms": [
          "HES",
          "hypereosinophilic disease",
          "hypereosinophilic disorder",
          "hypereosinophilic syndrome",
          "eosinophilia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage."
      },
      "child_count": 24,
      "reference_id": "MONDO:0015691"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16456,
      "label": "hypereosinophilic syndrome"
    }
  ]
}