{
  "id": 6692,
  "label": "B-cell acute lymphoblastic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004947",
  "properties": {
    "xrefs": [
      "DOID:0080630",
      "DOID:7061",
      "EFO:0000094",
      "GARD:0024135",
      "MEDGEN:226949",
      "NCIT:C8936",
      "SCTID:277571004",
      "UMLS:C1292769"
    ],
    "synonyms": [
      "B lymphoblastic leukemia/lymphoma",
      "precursor B lymphoblastic leukemia/lymphoma",
      "precursor B-lymphoblastic lymphoma/leukemia",
      "precursor B lymphoblastic lymphoma/leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 16,
  "parents": [
    {
      "id": 6710,
      "label": "acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5444,
        6890,
        7079,
        11789,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9952",
          "EFO:0000220",
          "GARD:0000522",
          "HP:0006721",
          "ICD10CM:C91.0",
          "ICD9:204",
          "ICD9:204.0",
          "ICD9:204.00",
          "ICD9:204.9",
          "ICDO:9835/3",
          "MEDGEN:7317",
          "NCIT:C3167",
          "Orphanet:513",
          "SCTID:91857003",
          "UMLS:C0023449"
        ],
        "synonyms": [
          "lymphoblastic leukaemia",
          "lymphoblastic leukemia",
          "ALL",
          "ALL - acute lymphocytic leukaemia",
          "ALL - acute lymphocytic leukemia",
          "acute lymphoblastic leukaemia (ALL)",
          "acute lymphoblastic leukaemia (disease)",
          "acute lymphoblastic leukemia",
          "acute lymphoblastic leukemia (ALL)",
          "acute lymphoblastic leukemia (disease)",
          "acute lymphoblastic leukemia/lymphoma",
          "acute lymphocytic leukaemia",
          "acute lymphocytic leukemia",
          "acute lymphocytic leukemias",
          "acute lymphogenous leukaemia",
          "acute lymphogenous leukemia",
          "acute lymphoid leukaemia",
          "acute lymphoid leukemia",
          "leukemia, lymphoblastic, malignant",
          "lymphoblastic leukemia, acute",
          "precursor Lymphoblasic leukaemia",
          "precursor Lymphoblasic leukemia",
          "precursor cell lymphoblastic leukaemia",
          "precursor cell lymphoblastic leukemia",
          "precursor lymphoblastic leukaemia",
          "precursor lymphoblastic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia."
      },
      "child_count": 60,
      "reference_id": "MONDO:0004967"
    },
    {
      "id": 16516,
      "label": "B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001938",
          "GARD:0020132",
          "NANDO:2200020",
          "NCIT:C3457",
          "Orphanet:171915"
        ],
        "synonyms": [
          "B-cell NHL",
          "B-cell lymphoma",
          "B-cell non Hodgkin's lymphoma",
          "B-cell non-Hodgkin lymphoma",
          "B-cell non-Hodgkin's lymphoma",
          "lymphomas non-Hodgkin's B-cell",
          "non-Hodgkin's B-cell lymphoma",
          "non-Hodgkin's lymphoma B-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003"
      },
      "child_count": 10,
      "reference_id": "MONDO:0015759"
    }
  ],
  "children": [
    {
      "id": 24397,
      "label": "B-cell acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080649",
          "GARD:0022348",
          "MEDGEN:396324",
          "NCIT:C80347",
          "Orphanet:585956",
          "SCTID:450956008",
          "UMLS:C2698315"
        ],
        "synonyms": [
          "B acute lymphoblastic leukaemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)",
          "B acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)",
          "B lymphoblastic leukaemia lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) (morphologic abnormality)",
          "B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) (morphologic abnormality)",
          "B-acute lymphoblastic leukaemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)",
          "B-acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)",
          "B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the E2A gene on chromosome 19 and the PBX1 gene on chromosome 1. It occurs in children and less often in adults."
      },
      "child_count": 0,
      "reference_id": "MONDO:0600030"
    },
    {
      "id": 25165,
      "label": "B-lymphoblastic leukemia/lymphoma MLL rearranged",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080644",
          "GARD:0026583"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B-lymphoblastic leukemia/lymphoma that is characterized by the presence of lymphoblasts that carry a translocation between the KMT2A gene at 11q23.3 and another gene partner resulting in the production of a KMT2A related fusion protein."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850156"
    },
    {
      "id": 25166,
      "label": "B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080645",
          "GARD:0026584"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B-lymphoblastic leukemia/lymphoma that is characterized by the presence of lymphoblasts that carry a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) fusion protein."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850157"
    },
    {
      "id": 25167,
      "label": "B-lymphoblastic leukemia/lymphoma with IL3-IGH",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080648",
          "GARD:0026585"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B-lymphoblastic leukemia/lymphoma that is characterized by the presence of lymphoblasts that carry a translocation between the IL3 gene on chromosome 5 and the IGH locus on chromosome 14, (q31.1;q32.3)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850160"
    },
    {
      "id": 25168,
      "label": "B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080650",
          "GARD:0026586",
          "NCIT:C129787"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B-lymphoblastic leukemia/lymphoma that has a gene expression profile similar to that of B-ALL with t(9;22)(q34.1;q11.2) BCR-ABL1, but lacks that gene fusion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850161"
    },
    {
      "id": 25169,
      "label": "B-lymphoblastic leukemia/lymphoma with IAMP21",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080651",
          "GARD:0026587",
          "NCIT:C130039"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B-lymphoblastic leukemia/lymphoma that is characterized by amplification of a portion of chromosome 21."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850162"
    },
    {
      "id": 25669,
      "label": "B-lymphoblastic leukemia/lymphoma with t(7;9)(q11.2;p13.2)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026825",
          "MEDGEN:1843410",
          "Orphanet:641372",
          "UMLS:C5816790"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957427"
    },
    {
      "id": 25670,
      "label": "B-lymphoblastic leukemia/lymphoma with t(17;19)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026826",
          "MEDGEN:1845507",
          "Orphanet:641375",
          "UMLS:C5856321"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957428"
    },
    {
      "id": 25844,
      "label": "B acute lymphoblastic leukemia with PAX5 P80R mutation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081411",
          "GARD:0026948",
          "MEDGEN:1846082",
          "NCIT:C199260",
          "UMLS:C5855498"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B-lymphoblastic leukemia/lymphoma that is associated with PAX5 P80R mutation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0958161"
    },
    {
      "id": 25845,
      "label": "B acute lymphoblastic leukemia with DUX4 rearrangement",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081412",
          "GARD:0026949",
          "MEDGEN:1848969",
          "NCIT:C199232",
          "UMLS:C5855478"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A B lymphoblastic leukemia/lymphoma that is associated with DUX4 gene rearrangement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0958162"
    },
    {
      "id": 26137,
      "label": "B-lymphoblastic leukemia with MEF2D rearrangement",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070623",
          "GARD:0028087"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975862"
    },
    {
      "id": 26138,
      "label": "B-lymphoblastic leukemia with MYC rearrangement",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070624",
          "GARD:0028088"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975863"
    },
    {
      "id": 26139,
      "label": "B-lymphoblastic leukemia with NUTM1 rearrangement",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070625",
          "GARD:0028089"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975864"
    },
    {
      "id": 26140,
      "label": "B-lymphoblastic leukemia with PAX5alt",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070626",
          "GARD:0028090"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975865"
    },
    {
      "id": 26141,
      "label": "B-lymphoblastic leukemia with TCF3-HLF fusion",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070627",
          "GARD:0028091"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975866"
    },
    {
      "id": 26142,
      "label": "B-lymphoblastic leukemia with ZNF384 rearrangement",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070628",
          "GARD:0028092"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975867"
    }
  ],
  "roots": [
    {
      "id": 6710,
      "label": "acute lymphoblastic leukemia"
    },
    {
      "id": 16516,
      "label": "B-cell non-Hodgkin lymphoma"
    }
  ]
}