{
  "id": 6693,
  "label": "B-cell chronic lymphocytic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004948",
  "properties": {
    "xrefs": [
      "DOID:1040",
      "EFO:0000095",
      "GARD:0006104",
      "ICD10CM:C91.1",
      "ICD9:204.1",
      "MEDGEN:44120",
      "MESH:D015451",
      "MedDRA:10008958",
      "NCIT:C3163",
      "NORD:971",
      "OMIM:151400",
      "Orphanet:67038",
      "UMLS:C0023434"
    ],
    "synonyms": [
      "B cell CLL",
      "B cell chronic lymphocytic leukaemia",
      "B cell chronic lymphocytic leukemia",
      "B cell lymphocytic leukaemia",
      "B cell lymphocytic leukemia",
      "B-CLL",
      "B-cell CLL",
      "B-cell chronic lymphocytic leukemia",
      "B-cell chronic lymphogenous leukaemia",
      "B-cell chronic lymphogenous leukemia",
      "B-cell chronic lymphoid leukaemia",
      "B-cell chronic lymphoid leukemia",
      "B-cell lymphocytic leukaemia",
      "B-cell lymphocytic leukemia",
      "BCLL",
      "CLL",
      "Chronic Lymphocytic Leukemia",
      "chronic B-cell lymphocytic leukaemia",
      "chronic B-cell lymphocytic leukemia",
      "chronic lymphatic leukemia",
      "chronic lymphocytic leukaemia (CLL)",
      "chronic lymphocytic leukemia",
      "chronic lymphocytic leukemia (CLL)",
      "chronic lymphogenous leukaemia",
      "chronic lymphogenous leukemia",
      "hematopoeitic - chronic lymphocytic leukaemia (CLL)",
      "hematopoeitic - chronic lymphocytic leukemia (CLL)",
      "lymphoplasmacytic leukemia",
      "leukemia, chronic LYMPHOCYTIC",
      "leukemia, chronic lymphatic",
      "leukemia, lymphocytic, chronic",
      "small lymphocytic lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3274,
      "label": "chronic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1036",
          "ICD9:208.10",
          "MEDGEN:220905",
          "NCIT:C3483",
          "SCTID:92812005",
          "UMLS:C1279296"
        ],
        "synonyms": [
          "chronic leukaemia (disease)",
          "chronic leukemia",
          "chronic leukemia (disease)",
          "leukaemia (disease), chronic",
          "leukemia (disease), chronic",
          "adult chronic leukaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia."
      },
      "child_count": 8,
      "reference_id": "MONDO:0001014"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:706",
          "EFO:0000096",
          "GARD:0024136",
          "ICD9:202.0",
          "MEDGEN:235305",
          "NCIT:C27910",
          "ONCOTREE:MBN",
          "SCTID:269476000",
          "UMLS:C1334633"
        ],
        "synonyms": [
          "mature B-cell lymphocytic neoplasm",
          "mature B-cell neoplasm",
          "mature B-cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004949"
    },
    {
      "id": 6710,
      "label": "acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5444,
        6890,
        7079,
        11789,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9952",
          "EFO:0000220",
          "GARD:0000522",
          "HP:0006721",
          "ICD10CM:C91.0",
          "ICD9:204",
          "ICD9:204.0",
          "ICD9:204.00",
          "ICD9:204.9",
          "ICDO:9835/3",
          "MEDGEN:7317",
          "NCIT:C3167",
          "Orphanet:513",
          "SCTID:91857003",
          "UMLS:C0023449"
        ],
        "synonyms": [
          "lymphoblastic leukaemia",
          "lymphoblastic leukemia",
          "ALL",
          "ALL - acute lymphocytic leukaemia",
          "ALL - acute lymphocytic leukemia",
          "acute lymphoblastic leukaemia (ALL)",
          "acute lymphoblastic leukaemia (disease)",
          "acute lymphoblastic leukemia",
          "acute lymphoblastic leukemia (ALL)",
          "acute lymphoblastic leukemia (disease)",
          "acute lymphoblastic leukemia/lymphoma",
          "acute lymphocytic leukaemia",
          "acute lymphocytic leukemia",
          "acute lymphocytic leukemias",
          "acute lymphogenous leukaemia",
          "acute lymphogenous leukemia",
          "acute lymphoid leukaemia",
          "acute lymphoid leukemia",
          "leukemia, lymphoblastic, malignant",
          "lymphoblastic leukemia, acute",
          "precursor Lymphoblasic leukaemia",
          "precursor Lymphoblasic leukemia",
          "precursor cell lymphoblastic leukaemia",
          "precursor cell lymphoblastic leukemia",
          "precursor lymphoblastic leukaemia",
          "precursor lymphoblastic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia."
      },
      "child_count": 60,
      "reference_id": "MONDO:0004967"
    },
    {
      "id": 17874,
      "label": "indolent B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021244",
          "MEDGEN:1741600",
          "NCIT:C171299",
          "Orphanet:300842",
          "UMLS:C5419078"
        ],
        "synonyms": [
          "indolent B-cell NHL",
          "B cell lymphoma, indolent",
          "indolent B cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0017594"
    }
  ],
  "children": [
    {
      "id": 5729,
      "label": "chronic lymphocytic leukemia/small lymphocytic lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6354",
          "GARD:0023704",
          "ICDO:9823/3",
          "MEDGEN:224906",
          "NCIT:C27911",
          "ONCOTREE:CLLSLL",
          "UMLS:C1302547"
        ],
        "synonyms": [
          "CLL/SLL",
          "chronic lymphocytic leukemia/small lymphocytic lymphoma",
          "chronic lymphocytic leukemia/small lymphocytic lymphoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An indolent, mature B-cell neoplasm composed of small, round B-lymphocytes. When the bone marrow and peripheral blood are involved, the term chronic lymphocytic leukemia is used. The term small lymphocytic lymphoma is restricted to cases which do not show leukemic involvement of the bone marrow and peripheral blood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003864"
    },
    {
      "id": 18857,
      "label": "hairy cell leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:285",
          "EFO:1000956",
          "GARD:0006560",
          "ICD10CM:C91.4",
          "ICD9:202.4",
          "ICDO:9940/3",
          "MEDGEN:9727",
          "MESH:D007943",
          "MedDRA:10019053",
          "MedDRA:10019055",
          "NCIT:C7402",
          "NORD:1213",
          "ONCOTREE:HCL",
          "Orphanet:58017",
          "SCTID:118613001",
          "UMLS:C0023443",
          "icd11.foundation:82152208"
        ],
        "synonyms": [
          "HCL",
          "HCL-C",
          "hairy cell leukemia",
          "leukemic reticuloendotheliosis",
          "classic hairy cell leukaemia",
          "classic hairy cell leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hairy cell leukemia (HCL) is a rare type of leukemia in which abnormal B-lymphocytes are present in the bone marrow, spleen and peripheral blood. It is a slowly progressive chronic lymphocytic leukemia (CLL). The name comes from the abnormally shaped lymphocytes with hair-like projections."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018935"
    }
  ],
  "roots": [
    {
      "id": 3274,
      "label": "chronic leukemia"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells"
    },
    {
      "id": 6710,
      "label": "acute lymphoblastic leukemia"
    },
    {
      "id": 17874,
      "label": "indolent B-cell non-Hodgkin lymphoma"
    }
  ]
}