{
  "id": 6694,
  "label": "neoplasm of mature B-cells",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004949",
  "properties": {
    "xrefs": [
      "DOID:706",
      "EFO:0000096",
      "GARD:0024136",
      "ICD9:202.0",
      "MEDGEN:235305",
      "NCIT:C27910",
      "ONCOTREE:MBN",
      "SCTID:269476000",
      "UMLS:C1334633"
    ],
    "synonyms": [
      "mature B-cell lymphocytic neoplasm",
      "mature B-cell neoplasm",
      "mature B-cell neoplasms"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 5930,
      "label": "B-cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569,
        6792
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:707",
          "GARD:0005877",
          "MEDGEN:86953",
          "MESH:D016393",
          "NCIT:C27907",
          "UMLS:C0079731"
        ],
        "synonyms": [
          "B-cell neoplasm",
          "B-cell lymphoma",
          "lymphoma, B-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004095"
    }
  ],
  "children": [
    {
      "id": 4634,
      "label": "primary central nervous system lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        4753,
        5530,
        6694,
        17548,
        17660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3234",
          "EFO:1000157",
          "GARD:0009318",
          "ICD9:200.5",
          "MEDGEN:79187",
          "MedDRA:10036685",
          "NCIT:C9301",
          "NORD:2002",
          "ONCOTREE:PCNSL",
          "Orphanet:46135",
          "SCTID:307649006",
          "UMLS:C0280803",
          "icd11.foundation:1133193893"
        ],
        "synonyms": [
          "CNS lymphoma",
          "PCNSL",
          "central nervous system lymphoma",
          "lymphoma of central nervous system",
          "malignant lymphomas of CNS",
          "malignant lymphomas of the CNS",
          "microglioma",
          "primary CNS lymphoma",
          "primary brain lymphoma",
          "primary central nervous system lymphoma",
          "primary lymphoma, CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002571"
    },
    {
      "id": 6693,
      "label": "B-cell chronic lymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6694,
        6710,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1040",
          "EFO:0000095",
          "GARD:0006104",
          "ICD10CM:C91.1",
          "ICD9:204.1",
          "MEDGEN:44120",
          "MESH:D015451",
          "MedDRA:10008958",
          "NCIT:C3163",
          "NORD:971",
          "OMIM:151400",
          "Orphanet:67038",
          "UMLS:C0023434"
        ],
        "synonyms": [
          "B cell CLL",
          "B cell chronic lymphocytic leukaemia",
          "B cell chronic lymphocytic leukemia",
          "B cell lymphocytic leukaemia",
          "B cell lymphocytic leukemia",
          "B-CLL",
          "B-cell CLL",
          "B-cell chronic lymphocytic leukemia",
          "B-cell chronic lymphogenous leukaemia",
          "B-cell chronic lymphogenous leukemia",
          "B-cell chronic lymphoid leukaemia",
          "B-cell chronic lymphoid leukemia",
          "B-cell lymphocytic leukaemia",
          "B-cell lymphocytic leukemia",
          "BCLL",
          "CLL",
          "Chronic Lymphocytic Leukemia",
          "chronic B-cell lymphocytic leukaemia",
          "chronic B-cell lymphocytic leukemia",
          "chronic lymphatic leukemia",
          "chronic lymphocytic leukaemia (CLL)",
          "chronic lymphocytic leukemia",
          "chronic lymphocytic leukemia (CLL)",
          "chronic lymphogenous leukaemia",
          "chronic lymphogenous leukemia",
          "hematopoeitic - chronic lymphocytic leukaemia (CLL)",
          "hematopoeitic - chronic lymphocytic leukemia (CLL)",
          "lymphoplasmacytic leukemia",
          "leukemia, chronic LYMPHOCYTIC",
          "leukemia, chronic lymphatic",
          "leukemia, lymphocytic, chronic",
          "small lymphocytic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004948"
    },
    {
      "id": 6702,
      "label": "plasma cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6536",
          "EFO:0000200",
          "GARD:0019440",
          "ICD9:238.6",
          "MEDGEN:368758",
          "MESH:D054219",
          "NCIT:C4665",
          "Orphanet:98282",
          "SCTID:415111003",
          "UMLS:C1959632"
        ],
        "synonyms": [
          "plasma cell dyscrasia",
          "plasma cell neoplasm",
          "plasma cell tumor",
          "plasma cell tumor, malignant",
          "plasmacytic neoplasm",
          "plasmacytic tumor",
          "plasmacytic tumour",
          "plasma cell disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance."
      },
      "child_count": 7,
      "reference_id": "MONDO:0004959"
    },
    {
      "id": 8648,
      "label": "Burkitt lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6694,
        17660,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8584",
          "EFO:0000309",
          "GARD:0005973",
          "ICD10CM:C83.7",
          "ICD9:200.2",
          "ICDO:9687/3",
          "MEDGEN:2377",
          "MESH:D002051",
          "MedDRA:10006595",
          "MedDRA:10053518",
          "MedDRA:10067184",
          "NCIT:C2912",
          "OMIM:113970",
          "ONCOTREE:BL",
          "Orphanet:543",
          "SCTID:118617000",
          "UMLS:C0006413",
          "icd11.foundation:2100138081"
        ],
        "synonyms": [
          "Burkitt lymphoma",
          "Burkitt lymphoma/leukemia",
          "Burkitt's lymphoma",
          "Burkitt's tumour",
          "Burkitt's tumour or lymphoma",
          "burkitt lymphoma, somatic",
          "small non-cleaved cell lymphoma",
          "small non-cleaved cell lymphoma, Burkitt's type",
          "BL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare form of malignant mature B-cell non-Hodgkin lymphoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0007243"
    },
    {
      "id": 9011,
      "label": "MALT lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6694,
        17884
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050909",
          "EFO:0000191",
          "GARD:0006485",
          "ICD10CM:C88.4",
          "ICD9:202.80",
          "ICDO:9699/3",
          "MEDGEN:66942",
          "MedDRA:10060707",
          "NCIT:C3898",
          "OMIM:137245",
          "ONCOTREE:EMALT",
          "Orphanet:52417",
          "SCTID:277622004",
          "UMLS:C0242647",
          "Wikipedia:MALT_lymphoma"
        ],
        "synonyms": [
          "Extranodal marginal zone B-cell lymphoma",
          "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue",
          "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)",
          "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue",
          "Immunocytoma",
          "MALT lymphoma",
          "MALT-lymphoma",
          "MALToma",
          "lymphoma of mucosa-associated lymphoid tissue",
          "lymphoma, MALT, somatic",
          "mucosa-associated lymphatic tissue lymphoma",
          "mucosa-associated lymphoid tissue lymphoma",
          "extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)",
          "familial primary gastric lymphoma",
          "gastric lymphoma, primary",
          "lymphoma, mucosa-associated lymphoid type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)"
      },
      "child_count": 15,
      "reference_id": "MONDO:0007650"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050745",
          "EFO:0000403",
          "GARD:0003178",
          "ICD10CM:C83.3",
          "ICD9:200.7",
          "ICDO:9680/3",
          "MEDGEN:86954",
          "MESH:D016403",
          "MedDRA:10012818",
          "NCIT:C8851",
          "Orphanet:544",
          "UMLS:C0079744",
          "icd11.foundation:1946973604"
        ],
        "synonyms": [
          "DLBCL",
          "diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common."
      },
      "child_count": 60,
      "reference_id": "MONDO:0018905"
    },
    {
      "id": 18834,
      "label": "follicular lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6694,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050873",
          "GARD:0002356",
          "HGNC:990",
          "ICD10CM:C82",
          "ICD10WHO:C82",
          "ICDO:9690/3",
          "MEDGEN:7417",
          "MESH:D008224",
          "NCIT:C3209",
          "NORD:1983",
          "ONCOTREE:FL",
          "Orphanet:545",
          "SCTID:308121000",
          "UMLS:C0024301",
          "icd11.foundation:797822185"
        ],
        "synonyms": [
          "follicle center lymphoma",
          "follicle centre lymphoma",
          "follicular center cell lymphoma",
          "follicular centre cell lymphoma",
          "follicular non-Hodgkin lymphoma",
          "follicular non-Hodgkin's lymphoma",
          "lymphoma, follicular center cell",
          "lymphoma, follicular centre cell",
          "lymphoma, follicular, malignant",
          "lymphoma, follicular"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Follicular lymphoma is a form of non-Hodgkin lymphoma characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018906"
    },
    {
      "id": 19286,
      "label": "B-cell prolymphocytic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3282,
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081041",
          "EFO:1000102",
          "GARD:0008223",
          "ICDO:9833/3",
          "MEDGEN:105396",
          "MESH:D054403",
          "NCIT:C4753",
          "ONCOTREE:BPLL",
          "Orphanet:86852",
          "SCTID:277619001",
          "UMLS:C0475801",
          "icd11.foundation:1997215876"
        ],
        "synonyms": [
          "B prolymphocytic leukaemia",
          "B prolymphocytic leukemia",
          "B-PLL",
          "B-cell prolymphocytic leukemia",
          "BPLL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019461"
    }
  ],
  "roots": [
    {
      "id": 5930,
      "label": "B-cell neoplasm"
    }
  ]
}