{
  "id": 6697,
  "label": "Hodgkins lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004952",
  "properties": {
    "xrefs": [
      "DOID:8567",
      "EFO:0000183",
      "GARD:0002714",
      "ICD10CM:C81",
      "ICD9:201",
      "ICD9:201.0",
      "ICD9:201.1",
      "ICD9:201.2",
      "ICD9:201.9",
      "ICD9:201.90",
      "ICDO:9650/3",
      "MESH:D006689",
      "NANDO:2200024",
      "NCIT:C9357",
      "NORD:1246",
      "ONCOTREE:HL",
      "Orphanet:98293",
      "icd11.foundation:1528863768"
    ],
    "synonyms": [
      "HL",
      "Hodgkin disease",
      "Hodgkin lymphoma",
      "Hodgkin's Disease",
      "Hodgkin's disease",
      "Hodgkin's lymphoma",
      "stage I subdiaphragmatic Hodgkin lymphoma",
      "stage II subdiaphragmatic Hodgkin lymphoma",
      "Hodgkin's sarcoma",
      "lymphoma, Hodgkin's"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6792,
      "label": "lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881,
        16514
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060058",
          "EFO:0000574",
          "ICD9:200.0",
          "ICD9:200.1",
          "ICD9:202.80",
          "ICDO:9590/3",
          "MEDGEN:44223",
          "MESH:D008223",
          "MedDRA:10025310",
          "NANDO:2100004",
          "NCIT:C3208",
          "ONCOTREE:MLYM",
          "Orphanet:223735",
          "SCTID:118600007",
          "UMLS:C0024299"
        ],
        "synonyms": [
          "lymphoma",
          "lymphoma (Hodgkin and non-Hodgkin)",
          "lymphoma (Hodgkin's and non-Hodgkin's)",
          "lymphoma, malignant",
          "lymphomatous",
          "malignant lymphoma",
          "MLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005062"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021147",
          "MEDGEN:797800",
          "MedDRA:10068349",
          "Orphanet:289644",
          "UMLS:C2363744"
        ],
        "synonyms": [
          "EBV-associated lymphoproliferative disorder",
          "Epstein-Barr virus-associated malignant lymphoproliferative disorder"
        ],
        "definition": "A range of lymphoproliferative diseases characterized by uncontrolled proliferation of B cells, T cells, or NK cells infected with Epstein-Barr virus. Depending on host immunity and viral factors, viral persistence in host cells can induce lymphoproliferation with a diverse clinical spectrum ranging from simple reactive hyperplasia to aggressive lymphoma/leukemia with unique clinical and pathological presentations."
      },
      "child_count": 11,
      "reference_id": "MONDO:0017343"
    }
  ],
  "children": [
    {
      "id": 7945,
      "label": "splenic hodgkin lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6697
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024409",
          "MEDGEN:56323",
          "NCIT:C7295",
          "SCTID:93527005",
          "UMLS:C0153791"
        ],
        "synonyms": [
          "Hodgkin's disease of spleen",
          "Hodgkin's disease of the spleen",
          "Hodgkin's lymphoma of spleen",
          "Hodgkin's lymphoma of the spleen",
          "primary splenic Hodgkin's lymphoma",
          "splenic Hodgkin's disease",
          "splenic Hodgkin's lymphoma",
          "splenic Hodgkins lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare Hodgkin lymphoma that arises from the spleen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006429"
    },
    {
      "id": 10580,
      "label": "classic Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6697
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016529",
          "MEDGEN:9283",
          "NCIT:C7164",
          "OMIM:236000",
          "ONCOTREE:CHL",
          "Orphanet:391",
          "UMLS:C0019829",
          "icd11.foundation:1616050398"
        ],
        "synonyms": [
          "classic Hodgkin disease",
          "classical Hodgkin lymphoma",
          "classical Hodgkin's lymphoma",
          "Chl",
          "Hodgkin disease",
          "Hodgkin lymphoma, susceptibility to",
          "lymphoma, Hodgkin, classic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Classical Hodgkin lymphoma (CHL) is a B-cell lymphoma characterized histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells."
      },
      "child_count": 8,
      "reference_id": "MONDO:0009348"
    },
    {
      "id": 11446,
      "label": "lymphoma, Hodgkin, X-linked pseudoautosomal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6697
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009899",
          "MEDGEN:335352",
          "MESH:C538326",
          "OMIM:300221",
          "UMLS:C1846167"
        ],
        "synonyms": [
          "Hodgkin disease susceptibility, pseudoautosomal",
          "lymphoma, Hodgkin, X-linked pseudoautosomal",
          "Hodgkin disease, X-linked Pseudoautosomal"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010273"
    },
    {
      "id": 11901,
      "label": "lymphoma, Hodgkin, Y-linked pseudoautosomal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6697
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024754",
          "MEDGEN:333246",
          "MESH:C564034",
          "OMIM:400021",
          "UMLS:C1839076"
        ],
        "synonyms": [
          "lymphoma, Hodgkin, Y-linked pseudoautosomal",
          "Hodgkin disease, Y-linked Pseudoautosomal"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010762"
    },
    {
      "id": 23434,
      "label": "nodular lymphocyte predominant Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6697
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019079",
          "ICD10CM:C81.0",
          "MEDGEN:233758",
          "NANDO:1201067",
          "NCIT:C7258",
          "ONCOTREE:NLPHL",
          "Orphanet:86893",
          "UMLS:C1334968",
          "icd11.foundation:331115338"
        ],
        "synonyms": [
          "Hodgkin lymphoma nodular LP, NOS",
          "Hodgkin lymphoma nodular lymphocyte predominant type, NOS",
          "NLPHL",
          "nodular lymphocyte predominant Hodgkin lymphoma",
          "nodular lymphocyte predominant Hodgkin's lymphoma",
          "nodular lymphocyte-predominant Hodgkin lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)"
      },
      "child_count": 1,
      "reference_id": "MONDO:0044778"
    }
  ],
  "roots": [
    {
      "id": 6792,
      "label": "lymphoma"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder"
    }
  ]
}