{
  "id": 6698,
  "label": "invasive ductal breast carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004953",
  "properties": {
    "xrefs": [
      "DOID:3008",
      "EFO:0000186",
      "ICD9:174.8",
      "ICDO:8500/3",
      "ICDO:8521/3",
      "MEDGEN:730612",
      "NCIT:C4194",
      "ONCOTREE:IDC",
      "SCTID:408643008",
      "UMLS:C1412014"
    ],
    "synonyms": [
      "infiltrating ductal adenocarcinoma",
      "infiltrating ductal breast carcinoma",
      "infiltrating ductal carcinoma",
      "infiltrating ductal carcinoma of breast",
      "infiltrating ductal carcinoma of the breast",
      "invasive ductal adenocarcinoma",
      "invasive ductal breast carcinoma",
      "invasive ductal carcinoma",
      "invasive ductal carcinoma of breast",
      "invasive ductal carcinoma of the breast",
      "invasive ductal carcinoma, NST",
      "invasive ductal carcinoma, No specific type",
      "breast invasive ductal carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 7234,
      "label": "breast ductal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3007",
          "EFO:0006318",
          "MEDGEN:315942",
          "MESH:D018270",
          "NCIT:C4017",
          "UMLS:C1527349"
        ],
        "synonyms": [
          "duct adenocarcinoma",
          "duct carcinoma",
          "ductal adenocarcinoma",
          "ductal carcinoma",
          "breast ductal carcinoma",
          "ductal breast adenocarcinoma",
          "ductal breast carcinoma",
          "ductal carcinoma of breast",
          "ductal carcinoma of the breast",
          "mammary duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast carcinoma arising from the ducts. While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast. Ductal carcinomas account for about two thirds of all breast cancers. Two types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. The latter often spreads to the axillary lymph nodes and other anatomic sites. The two forms of ductal carcinoma often coexist."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005590"
    },
    {
      "id": 7803,
      "label": "invasive breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000307",
          "MEDGEN:163435",
          "NCIT:C9245",
          "ONCOTREE:BRCA",
          "SCTID:713609000",
          "UMLS:C0853879",
          "icd11.foundation:2090549892"
        ],
        "synonyms": [
          "infiltrating breast cancer",
          "infiltrating breast carcinoma",
          "infiltrating carcinoma of breast",
          "infiltrating carcinoma of the breast",
          "invasive breast cancer",
          "invasive breast carcinoma",
          "invasive carcinoma of breast",
          "invasive carcinoma of the breast",
          "invasive mammary carcinoma",
          "BRCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women."
      },
      "child_count": 22,
      "reference_id": "MONDO:0006256"
    }
  ],
  "children": [
    {
      "id": 4748,
      "label": "breast mucinous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6698,
        6700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3610",
          "MEDGEN:235337",
          "NCIT:C9131",
          "ONCOTREE:IMMC",
          "SCTID:444712000",
          "UMLS:C1334807"
        ],
        "synonyms": [
          "breast mucinous carcinoma",
          "colloid breast carcinoma",
          "colloid carcinoma of breast",
          "colloid carcinoma of the breast",
          "infiltrating colloid breast carcinoma",
          "infiltrating mucinous breast carcinoma",
          "invasive colloid breast carcinoma",
          "invasive mucinous breast carcinoma",
          "mucinous breast cancer",
          "mucinous breast carcinoma",
          "mucinous carcinoma of breast",
          "mucinous carcinoma of the breast",
          "breast invasive mixed mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma of the breast characterized by the presence of islands of small and uniform cells, surrounded by large amounts of mucin. Pure mucinous breast carcinomas generally have a favorable prognosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002707"
    },
    {
      "id": 5164,
      "label": "breast secretory carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6698
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4922",
          "ICDO:8502/3",
          "ICDO:8508/3",
          "MEDGEN:87226",
          "MESH:C537535",
          "NCIT:C4189",
          "ONCOTREE:JSCB",
          "UMLS:C0334371"
        ],
        "synonyms": [
          "cystic hypersecretory breast carcinoma",
          "cystic hypersecretory carcinoma of breast",
          "cystic hypersecretory carcinoma of the breast",
          "infiltrating cystic hypersecretory duct breast carcinoma",
          "invasive cystic hypersecretory duct breast carcinoma",
          "juvenile breast carcinoma",
          "juvenile carcinoma of breast",
          "juvenile carcinoma of the breast",
          "juvenile carcinoma of the breast (morphologic abnormality)",
          "juvenile secretory breast carcinoma",
          "juvenile secretory carcinoma of breast",
          "juvenile secretory carcinoma of the breast",
          "secretory breast carcinoma",
          "secretory carcinoma",
          "secretory carcinoma of breast",
          "secretory carcinoma of the breast",
          "JSCB",
          "SBC",
          "juvenile carcinoma (formerly)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A rare, low grade invasive adenocarcinoma of the breast characterized by the presence of cells that secrete milk-like material. Morphologically, it usually appears as a circumscribed lesion, composed of cystic spaces, tubular structures, and solid areas."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003208"
    },
    {
      "id": 5322,
      "label": "glycogen-rich clear cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698,
        6742,
        23541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5310",
          "ICDO:8315/3",
          "MEDGEN:1785052",
          "NCIT:C40368",
          "UMLS:C2012261"
        ],
        "synonyms": [
          "glycogen-rich carcinoma",
          "glycogen-rich carcinoma (morphologic abnormality)",
          "glycogen-rich, clear cell breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An uncommon, usually aggressive adenocarcinoma of the breast characterized by the presence of clear cells that contain glycogen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003390"
    },
    {
      "id": 5515,
      "label": "acinic cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698,
        6708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5743",
          "GARD:0027643",
          "MEDGEN:272988",
          "NCIT:C40367",
          "UMLS:C1515868"
        ],
        "synonyms": [
          "acinar cell breast carcinoma",
          "acinic cell breast carcinoma",
          "breast carcinoma of acinar cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast adenocarcinoma characterized by the presence of serous (acinic cell) differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003624"
    },
    {
      "id": 5795,
      "label": "invasive tubular breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698,
        7247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6587",
          "MEDGEN:230969",
          "NCIT:C9135",
          "UMLS:C1328544"
        ],
        "synonyms": [
          "breast tubular adenocarcinoma",
          "infiltrating tubular breast carcinoma",
          "infiltrating tubular carcinoma of breast",
          "infiltrating tubular carcinoma of the breast",
          "invasive tubular breast carcinoma",
          "invasive tubular carcinoma of breast",
          "invasive tubular carcinoma of the breast",
          "tubular breast cancer",
          "tubular breast carcinoma",
          "tubular carcinoma of breast",
          "tubular carcinoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma of the breast with a favorable prognosis. It is composed of tubular structures lined by a single layer of epithelium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003936"
    },
    {
      "id": 6105,
      "label": "scirrhous breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7578",
          "ICDO:8514/3",
          "MEDGEN:87541",
          "NCIT:C7362",
          "SCTID:254839007",
          "UMLS:C0346151"
        ],
        "synonyms": [
          "infiltrating carcinoma of breast with fibrotic Stroma",
          "infiltrating carcinoma of the breast with fibrotic Stroma",
          "scirrhous breast carcinoma",
          "scirrhous carcinoma of breast",
          "scirrhous carcinoma of the breast",
          "breast scirrhous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An infiltrating ductal breast carcinoma associated with stromal fibrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004288"
    },
    {
      "id": 6725,
      "label": "basal-like breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698,
        7150
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000281",
          "MEDGEN:770987",
          "NCIT:C53558",
          "UMLS:C3642347"
        ],
        "synonyms": [
          "basal-like breast cancer",
          "basal-like breast carcinoma",
          "basal-like subtype of breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin 8, CX3CL1, and TRIM29, and usually by lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is the most common subtype of breast cancer associated with BRCA1 mutations, and is associated with a poor prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004984"
    },
    {
      "id": 6781,
      "label": "invasive ductal and lobular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698,
        7844
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000552",
          "ICDO:8522/3",
          "MEDGEN:235231",
          "NCIT:C7688",
          "UMLS:C1334277"
        ],
        "synonyms": [
          "infiltrating ductal and lobular carcinoma",
          "invasive duct and lobular carcinoma",
          "invasive ductal and lobular carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive ductal breast carcinoma associated with a lobular carcinomatous component. The lobular carcinomatous component may be in situ or invasive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005050"
    },
    {
      "id": 6793,
      "label": "medullary breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5605",
          "EFO:0000580",
          "ICDO:8512/3",
          "MEDGEN:163568",
          "NCIT:C9119",
          "UMLS:C0860580"
        ],
        "synonyms": [
          "infiltrating medullary carcinoma of breast",
          "infiltrating medullary carcinoma of the breast",
          "invasive medullary breast carcinoma",
          "invasive medullary carcinoma of breast",
          "invasive medullary carcinoma of the breast",
          "medullary breast cancer",
          "medullary breast carcinoma",
          "medullary breast carcinoma with lymphoid Stroma",
          "medullary carcinoma of breast",
          "medullary carcinoma of the breast",
          "breast medullary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An infiltrating breast carcinoma with a relatively favorable prognosis. It is an uncommon carcinoma, accounting for less than 1% of all infiltrating breast carcinomas. It is well circumscribed, with soft cut surface and often of considerable size. Microscopically, the predominant growth pattern is syncytial with broad anastomosing bands or sheets of malignant cells. The malignant cells are round with abundant cytoplasm and vesicular nuclei. The sheets of malignant cells are associated with a marked lymphoplasmacytic infiltrate. Glandular or tubular structures are absent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005063"
    },
    {
      "id": 7635,
      "label": "pleomorphic breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000047",
          "MEDGEN:307976",
          "NCIT:C5161",
          "UMLS:C1514169"
        ],
        "synonyms": [
          "anaplastic breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A rare, aggressive, high grade invasive ductal carcinoma, not otherwise specified. It is characterized by the presence of pleomorphic and bizarre malignant cells that constitute more than 50 percent of the malignant cellular infiltrate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006050"
    }
  ],
  "roots": [
    {
      "id": 7234,
      "label": "breast ductal adenocarcinoma"
    },
    {
      "id": 7803,
      "label": "invasive breast carcinoma"
    }
  ]
}