{
  "id": 6701,
  "label": "oral cavity squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004958",
  "properties": {
    "xrefs": [
      "DOID:0050866",
      "EFO:0000199",
      "GARD:0017932",
      "MEDGEN:108436",
      "NCIT:C4833",
      "ONCOTREE:OCSC",
      "Orphanet:502363",
      "SCTID:307502000",
      "UMLS:C0585362"
    ],
    "synonyms": [
      "mouth scc",
      "mouth squamous cell carcinoma",
      "oral cavity scc",
      "oral cavity squamous cell cancer",
      "oral cavity squamous cell carcinoma",
      "scc of mouth",
      "scc of oral cavity",
      "scc of the mouth",
      "scc of the oral cavity",
      "squamous cell carcinoma of mouth",
      "squamous cell carcinoma of oral cavity",
      "squamous cell carcinoma of the mouth",
      "squamous cell carcinoma of the oral cavity",
      "OCSC",
      "oral squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      },
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 23401,
      "label": "lip and oral cavity squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11332,
        21254,
        21538
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022046",
          "MEDGEN:124714",
          "NCIT:C42690",
          "Orphanet:502369",
          "UMLS:C0280297"
        ],
        "synonyms": [
          "lip and oral cavity squamous cell cancer",
          "lip and oral cavity squamous cell carcinoma",
          "lip/oral cavity squam. cell car.",
          "squamous cell carcinoma of oral cavity and lip"
        ],
        "categories": [
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes."
      },
      "child_count": 3,
      "reference_id": "MONDO:0044710"
    },
    {
      "id": 23483,
      "label": "oral cavity carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7170,
        7738,
        21254
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027982",
          "MEDGEN:57468",
          "NCIT:C8990",
          "UMLS:C0151546"
        ],
        "synonyms": [
          "oral cavity cancer",
          "carcinoma of mouth",
          "carcinoma of oral cavity",
          "carcinoma of the oral cavity",
          "mouth carcinoma",
          "oral cavity carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma."
      },
      "child_count": 27,
      "reference_id": "MONDO:0044925"
    }
  ],
  "children": [
    {
      "id": 2957,
      "label": "tongue squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6418,
        6701
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050865",
          "GARD:0022779",
          "MEDGEN:91153",
          "NCIT:C4648",
          "SCTID:276952000",
          "UMLS:C0349566"
        ],
        "synonyms": [
          "scc of the tongue",
          "scc of tongue",
          "squamous cell carcinoma of the tongue",
          "squamous cell carcinoma of tongue",
          "tongue scc",
          "tongue squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the tongue. It usually presents as a painful ulcerated or nodular lesion. The size of the tumor and the status of the lymph nodes are the most important factors that determine prognosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000500"
    },
    {
      "id": 6205,
      "label": "maxillary sinus squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3934,
        6701,
        23399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7910",
          "GARD:0023975",
          "MEDGEN:277348",
          "NCIT:C6064",
          "SCTID:707354003",
          "UMLS:C1334647",
          "icd11.foundation:1253589818"
        ],
        "synonyms": [
          "epidermoid carcinoma of maxillary antrum",
          "epidermoid carcinoma of maxillary sinus",
          "epidermoid carcinoma of maxillofacial sinus",
          "epidermoid carcinoma of the maxillary antrum",
          "epidermoid carcinoma of the maxillary sinus",
          "maxillary antrum epidermoid carcinoma",
          "maxillary antrum squamous cell carcinoma",
          "maxillary sinus epidermoid carcinoma",
          "maxillary sinus squamous cell carcinoma",
          "maxillofacial sinus epidermoid carcinoma",
          "maxillofacial sinus squamous cell carcinoma",
          "squamous cell carcinoma of maxillary antrum",
          "squamous cell carcinoma of maxillary sinus",
          "squamous cell carcinoma of maxillofacial sinus",
          "squamous cell carcinoma of the maxillary antrum",
          "squamous cell carcinoma of the maxillary sinus",
          "squamous cell carcinoma of the maxillofacial sinus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the mucosal epithelial surface of the maxillary sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004394"
    },
    {
      "id": 20559,
      "label": "squamous cell carcinoma of lip",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6701,
        20509
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017933",
          "MEDGEN:79099",
          "NCIT:C4042",
          "Orphanet:502366",
          "SCTID:255071008",
          "UMLS:C0280302",
          "icd11.foundation:1635251327"
        ],
        "synonyms": [
          "lip scc",
          "lip squamous cell carcinoma",
          "scc of Lip",
          "scc of the Lip",
          "squamous cell carcinoma of the Lip"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the lip."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021427"
    },
    {
      "id": 20560,
      "label": "squamous cell carcinoma of floor of mouth",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6701,
        20515
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025317",
          "MEDGEN:124715",
          "NCIT:C4041",
          "SCTID:276954004",
          "UMLS:C0280300",
          "icd11.foundation:755941113"
        ],
        "synonyms": [
          "floor of mouth scc",
          "floor of mouth squamous cell carcinoma",
          "mouth floor squamous cell carcinoma",
          "scc of floor of mouth",
          "scc of the floor of mouth",
          "squamous cell carcinoma of the floor of mouth"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the mouth floor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021429"
    },
    {
      "id": 20561,
      "label": "squamous cell carcinoma of buccal mucosa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6431,
        6701
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025318",
          "MEDGEN:83627",
          "NCIT:C4040",
          "SCTID:254437001",
          "UMLS:C0280299"
        ],
        "synonyms": [
          "buccal mucosa squamous cell carcinoma",
          "scc of buccal mucosa",
          "scc of the buccal mucosa",
          "squamous cell carcinoma of the buccal mucosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the buccal mucosa."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021431"
    },
    {
      "id": 20654,
      "label": "verrucous carcinoma of oral cavity",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6701,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025335",
          "MEDGEN:124716",
          "NCIT:C8174",
          "SCTID:403889000",
          "UMLS:C0280306"
        ],
        "synonyms": [
          "mouth verrucous carcinoma",
          "oral cavity verrucous cancer",
          "oral cavity verrucous carcinoma",
          "verrucous carcinoma of mouth",
          "verrucous carcinoma of the mouth",
          "verrucous carcinoma of the oral cavity"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A verrucous carcinoma that involves the oral cavity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021538"
    },
    {
      "id": 23416,
      "label": "salivary gland squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2972,
        6701,
        17510
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001967",
          "GARD:0017929",
          "MEDGEN:83545",
          "NCIT:C7991",
          "Orphanet:500481",
          "UMLS:C0279697"
        ],
        "synonyms": [
          "SCC of salivary gland",
          "SCC of the salivary gland",
          "epidermoid carcinoma of salivary gland",
          "epidermoid carcinoma of the salivary gland",
          "saliva-secreting gland squamous cell carcinoma",
          "salivary gland SCC",
          "salivary gland epidermoid carcinoma",
          "salivary gland squamous cell cancer",
          "salivary gland squamous cell carcinoma",
          "squamous cell carcinoma of salivary gland",
          "squamous cell carcinoma of the salivary gland",
          "squamous cell carcinoma of salivary glands"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the salivary glands. The majority of patients are in their sixth through eight decades. It usually presents as a rapidly enlarging mass, which may be painful. It usually has an aggressive clinical course."
      },
      "child_count": 6,
      "reference_id": "MONDO:0044740"
    }
  ],
  "roots": [
    {
      "id": 23401,
      "label": "lip and oral cavity squamous cell carcinoma"
    },
    {
      "id": 23483,
      "label": "oral cavity carcinoma"
    }
  ]
}