{
  "id": 6703,
  "label": "monoclonal gammopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004960",
  "properties": {
    "xrefs": [
      "EFO:0000203",
      "GARD:0024137",
      "ICD10CM:D47.2",
      "MEDGEN:210153",
      "MESH:D010265",
      "NCIT:C35548",
      "SCTID:109983007",
      "UMLS:C1136085"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A condition characterized by the abnormal presence of monoclonal immunoglobulins in the blood or urine."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7217,
      "label": "hematologic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:74",
          "EFO:0005803",
          "GTR:AN1320635",
          "ICD10CM:D50-D89",
          "ICD9:280-289",
          "ICD9:289.8",
          "ICD9:289.9",
          "MEDGEN:5483",
          "MESH:D006402",
          "NANDO:1100006",
          "NANDO:2100175",
          "NCIT:C26323",
          "Orphanet:97992",
          "SCTID:414022008",
          "UMLS:C0018939"
        ],
        "synonyms": [
          "blood disease",
          "blood disorder",
          "disease of hematopoietic system",
          "disease of the blood and blood-forming organs",
          "disease or disorder of haematopoietic system",
          "disease or disorder of hematopoietic system",
          "disorder of haematopoietic system",
          "disorder of hematopoietic system",
          "haematological disease",
          "haematological disorder",
          "haematological system disease",
          "haematopoietic disease",
          "haematopoietic system disease or disorder",
          "hematologic and lymphocytic disorder",
          "hematologic disorder",
          "hematological disease",
          "hematological disorder",
          "hematological system disease",
          "hematopoietic disease",
          "hematopoietic system disease",
          "hematopoietic system disease or disorder",
          "rare hematologic disease",
          "haematological disorders and malignancies",
          "hematological disorders and malignancies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease involving the hematopoietic system."
      },
      "child_count": 27,
      "reference_id": "MONDO:0005570"
    }
  ],
  "children": [
    {
      "id": 4389,
      "label": "monoclonal paraproteinemia disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4388,
        6703
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2346",
          "GARD:0023106",
          "HP:0031047",
          "ICD9:273.1",
          "MEDGEN:10088",
          "NCIT:C35878",
          "SCTID:267440005",
          "UMLS:C0026471"
        ],
        "synonyms": [
          "paraproteinaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease characterized by the presence of excessive amounts of paraprotein or single monoclonal gammaglobulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002274"
    },
    {
      "id": 6047,
      "label": "monoclonal gammopathy of uncertain significance",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6703
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7442",
          "GARD:0007034",
          "ICD9:238.6",
          "ICDO:9765/1",
          "MEDGEN:44485",
          "MESH:D008998",
          "NCIT:C3996",
          "ONCOTREE:MGUS",
          "SCTID:277577000",
          "SCTID:58648008",
          "UMLS:C0026470"
        ],
        "synonyms": [
          "MGUS",
          "benign monoclonal gammopathy",
          "monoclonal gammopathy Of undetermined significance (MGUS)",
          "monoclonal gammopathy of undetermined significance",
          "monoclonal gammopathy of undetermined significance (MGUS)",
          "monoclonal gammopathy of undetermined significance (morphologic abnormality)",
          "monoclonal gammopathy of unknown significance",
          "monoclonal gammopathy, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A condition characterized by the presence of a monoclonal gammopathy (MG) in which the clonal mass has not reached a predefined state in which the condition is considered malignant. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004225"
    },
    {
      "id": 19397,
      "label": "acquired monoclonal Ig light chain-associated Fanconi syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6703
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019154",
          "MEDGEN:1375627",
          "Orphanet:91136",
          "SCTID:724099000",
          "UMLS:C4510369"
        ],
        "synonyms": [
          "acquired Fanconi syndrome secondary to monoclonal gammopathy",
          "acquired monoclonal immunoglobulin light chain-associated Fanconi syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare monoclonalgammopathy characterized by renal proximal tubule dysfunction secondary to monoclonal kappa light chain deposits in proximal tubular cells. Clinical presentation is with variable chronic kidney disease, low molecular weight proteinuria, aminoaciduria, hyperphosphaturia, uricosuria, bicarbonaturia, and non-diabetic glycosuria. Renal phosphate and urate wasting may cause hypophosphatemia and hypouricaemia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019604"
    }
  ],
  "roots": [
    {
      "id": 7217,
      "label": "hematologic disorder"
    }
  ]
}