{ "id": 6712, "label": "adenocarcinoma", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0004970", "properties": { "xrefs": [ "CSP:2000-0386", "DOID:299", "EFO:0000228", "ICDO:8140/3", "MEDGEN:122", "MESH:D000230", "NCIT:C2852", "ONCOTREE:ADNOS", "SCTID:443961001", "UMLS:C0001418" ], "synonyms": [ "adenocarcinoma", "adenocarcinoma NOS (morphologic abnormality)", "adenocarcinoma, malignant", "adenocarcinoma, no subtype (morphologic abnormality)", "adenocarcinomas", "ADNOS" ], "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma." }, "isLeaf": false, "isRoot": false, "child_count": 64, "parents": [ { "id": 6734, "label": "carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7265 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-1867", "DOID:305", "EFO:0000313", "ICDO:8010/3", "ICDO:8011/3", "MEDGEN:2867", "MESH:D002277", "NCIT:C2916", "SCTID:722688002", "UMLS:C0007097" ], "synonyms": [ "epithelioma", "Other carcinoma", "carcinoma", "carcinoma, malignant", "epithelial carcinoma", "epithelioma malignant", "malignant epithelial neoplasm", "malignant epithelial tumor", "malignant epithelial tumour", "malignant epithelioma" ], "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." }, "child_count": 98, "reference_id": "MONDO:0004993" }, { "id": 21312, "label": "glandular cell neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 7265 ], "type_id": 0, "properties": { "xrefs": [ "HP:0031493", "MEDGEN:64458", "NCIT:C7132", "UMLS:C0205854" ], "synonyms": [ "glandular cell epithelial neoplasm", "glandular cell epithelium neoplasm", "glandular cell neoplasm", "glandular cell tumor", "glandular cell tumour" ] }, "child_count": 10, "reference_id": "MONDO:0024276" } ], "children": [ { "id": 3277, "label": "epididymal adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3276, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10368", "MEDGEN:307180", "NCIT:C39957", "UMLS:C1510784" ], "synonyms": [ "adenocarcinoma of the epididymis", "epididymal adenocarcinoma", "epididymis adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A rare adenocarcinoma that arises from the epididymis. It usually presents as a scrotal mass and may be associated with testicular pain." }, "child_count": 0, "reference_id": "MONDO:0001017" }, { "id": 4151, "label": "rete testis adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 5463, 6712, 7111 ], "type_id": 0, "properties": { "xrefs": [ "DOID:14544", "MEDGEN:209023", "NCIT:C8955", "UMLS:C0863024" ], "synonyms": [ "adenocarcinoma of rete testis", "adenocarcinoma of the rete testis", "carcinoma, rete testis, malignant", "rete testis adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the rete testis" }, "child_count": 0, "reference_id": "MONDO:0001992" }, { "id": 4152, "label": "seminal vesicle adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4818, 6712, 7111 ], "type_id": 0, "properties": { "xrefs": [ "DOID:14545", "MEDGEN:311271", "NCIT:C39906", "UMLS:C1519233" ], "synonyms": [ "seminal vesicle adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the seminal vesicle" }, "child_count": 0, "reference_id": "MONDO:0001993" }, { "id": 4507, "label": "ethmoid sinus adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3947, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2766", "GARD:0023134", "MEDGEN:272595", "NCIT:C6237", "UMLS:C1333472" ], "synonyms": [ "adenocarcinoma of the ethmoid sinus" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the epithelial cell" }, "child_count": 0, "reference_id": "MONDO:0002418" }, { "id": 4555, "label": "lacrimal gland adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4543, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:298", "MEDGEN:87556", "NCIT:C4541", "SCTID:254988008", "UMLS:C0346341" ], "synonyms": [ "adenocarcinoma of lacrimal gland", "adenocarcinoma of the lacrimal gland", "lacrimal gland adenocarcinoma" ], "categories": [ { "ref": "MONDO:0002022", "name": "disorder of orbital region" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0024458", "name": "disorder of visual system" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the lacrimal gland" }, "child_count": 4, "reference_id": "MONDO:0002475" }, { "id": 4583, "label": "papillary adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 8000 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3112", "ICDO:8260/3", "MEDGEN:123", "MESH:D000231", "NCIT:C2853", "UMLS:C0001420" ], "synonyms": [ "adenocarcinoma, papillary, malignant", "papillary adenocarcinoma", "papillary adenocarcinoma (morphologic abnormality)", "papillary adenocarcinoma NOS (morphologic abnormality)", "infiltrating and papillary adenocarcinoma", "infiltrating papillary adenocarcinoma" ], "definition": "A morphologic variant of adenocarcinoma. It is characterized by the presence of a papillary growth pattern. Representative examples include thyroid gland papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous surface papillary adenocarcinoma." }, "child_count": 22, "reference_id": "MONDO:0002512" }, { "id": 4781, "label": "fallopian tube adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 7759 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3706", "GARD:0023231", "MEDGEN:232183", "NCIT:C6265", "UMLS:C1333590" ], "synonyms": [ "adenocarcinoma of fallopian tube", "adenocarcinoma of the fallopian tube", "fallopian tube adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the fallopian tube" }, "child_count": 10, "reference_id": "MONDO:0002746" }, { "id": 4786, "label": "bladder adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 6727 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3711", "EFO:1000125", "MEDGEN:76014", "NCIT:C4032", "ONCOTREE:BLAD", "SCTID:255110003", "UMLS:C0279682" ], "synonyms": [ "adenocarcinoma of bladder", "adenocarcinoma of the bladder", "adenocarcinoma of the urinary bladder", "adenocarcinoma of urinary bladder", "bladder adenocarcinoma", "urinary bladder adenocarcinoma", "blad" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the urinary bladder" }, "child_count": 14, "reference_id": "MONDO:0002751" }, { "id": 4787, "label": "ovarian adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 6864 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3713", "EFO:0006460", "GARD:0020466", "MEDGEN:181757", "MedDRA:10051938", "NCIT:C7700", "Orphanet:213504", "UMLS:C0948216" ], "synonyms": [ "adenocarcinoma of ovary", "adenocarcinoma of the ovary", "ovarian adenocarcinoma", "ovary adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma." }, "child_count": 14, "reference_id": "MONDO:0002752" }, { "id": 4845, "label": "trabecular adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3965", "ICDO:8190/3", "ICDO:8332/3", "MEDGEN:86214", "NCIT:C4068", "UMLS:C0302182" ], "synonyms": [ "trabecula adenocarcinoma", "trabecular adenocarcinoma", "trabecular adenocarcinoma (morphologic abnormality)", "trabecular carcinoma", "Merkel cell carcinoma" ], "definition": "A malignant epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern." }, "child_count": 0, "reference_id": "MONDO:0002822" }, { "id": 5148, "label": "middle ear adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 5149, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4892", "MEDGEN:235326", "NCIT:C6848", "UMLS:C1334758" ], "synonyms": [ "adenocarcinoma of middle Ear", "adenocarcinoma of the middle Ear", "adenocarcinoma of the middle ear", "middle Ear adenocarcinoma", "middle ear adenocarcinoma" ], "categories": [ { "ref": "MONDO:0002409", "name": "auditory system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the middle ear" }, "child_count": 0, "reference_id": "MONDO:0003189" }, { "id": 5152, "label": "bile duct adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 7152 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4896", "GARD:0023406", "MEDGEN:234585", "NCIT:C27813", "UMLS:C1370800" ], "synonyms": [ "bile duct adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the bile duct" }, "child_count": 2, "reference_id": "MONDO:0003193" }, { "id": 5156, "label": "granular cell carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 5197, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4903", "GARD:0023408", "ICDO:8320/3", "MEDGEN:104695", "NCIT:C3681", "UMLS:C0205644" ], "synonyms": [ "granular cell adenocarcinoma", "granular cell carcinoma", "granular cell carcinoma (morphologic abnormality)" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "An adenocarcinoma characterized by the presence of malignant epithelial cells with granular cytoplasm." }, "child_count": 0, "reference_id": "MONDO:0003197" }, { "id": 5157, "label": "small intestine adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 7176 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4906", "EFO:1000532", "GARD:0019851", "MEDGEN:82984", "NCIT:C7888", "Orphanet:104075", "SCTID:424440001", "UMLS:C0278803", "icd11.foundation:1369513329" ], "synonyms": [ "adenocarcinoma - small intest.", "adenocarcinoma of small bowel", "adenocarcinoma of small intestine", "adenocarcinoma of the small bowel", "adenocarcinoma of the small intestine", "small bowel adenocarcinoma", "small intestinal adenocarcinoma", "small intestine adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "An adenocarcinoma that arises from the small intestine. Histologic variants include mucinous adenocarcinoma and signet ring cell carcinoma." }, "child_count": 4, "reference_id": "MONDO:0003198" }, { "id": 5159, "label": "urethra adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 20506 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4910", "GARD:0027635", "MEDGEN:234461", "NCIT:C6167", "ONCOTREE:UAD", "UMLS:C1336885" ], "synonyms": [ "adenocarcinoma of the urethra", "adenocarcinoma of urethra", "urethra adenocarcinoma", "urethral adenocarcinoma", "UAD" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the urethra" }, "child_count": 2, "reference_id": "MONDO:0003200" }, { "id": 5161, "label": "villous adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4917", "ICDO:8262/3", "MEDGEN:137741", "NCIT:C4142", "UMLS:C0334306" ], "synonyms": [ "villous adenocarcinoma", "villous adenocarcinoma (morphologic abnormality)" ], "definition": "An adenocarcinoma characterized by the presence of a villous architectural pattern. It may arise from a villous adenoma." }, "child_count": 2, "reference_id": "MONDO:0003204" }, { "id": 5165, "label": "thymus gland adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 7956 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4923", "GARD:0023411", "MEDGEN:234426", "NCIT:C6459", "UMLS:C1336743" ], "synonyms": [ "Thymus adenocarcinoma", "adenocarcinoma of Thymus", "adenocarcinoma of the Thymus", "thymic adenocarcinoma", "thymus adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "A rare primary thymic carcinoma, characterized by the presence of carcinoma cells with glandular differentiation." }, "child_count": 4, "reference_id": "MONDO:0003209" }, { "id": 5167, "label": "nasal cavity adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 5168, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4930", "MEDGEN:233746", "NCIT:C6015", "UMLS:C1334920" ], "synonyms": [ "adenocarcinoma of nasal cavity", "adenocarcinoma of the nasal cavity", "nasal cavity adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the nasal cavity" }, "child_count": 0, "reference_id": "MONDO:0003211" }, { "id": 5171, "label": "ureter adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712, 7978 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4938", "MEDGEN:234456", "NCIT:C6155", "UMLS:C1336873" ], "synonyms": [ "adenocarcinoma of the ureter", "adenocarcinoma of ureter", "ureter adenocarcinoma", "ureteral adenocarcinoma" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the ureter" }, "child_count": 0, "reference_id": "MONDO:0003216" }, { "id": 5172, "label": "adenocarcinoma in situ", "isLeaf": false, "isRoot": false, "parents": [ 6433, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4943", "ICDO:8140/2", "MEDGEN:87203", "MESH:D065311", "NCIT:C4123", "ONCOTREE:AIS", "UMLS:C0334276" ], "synonyms": [ "adenocarcinoma in situ", "AIS" ], "definition": "A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics." }, "child_count": 6, "reference_id": "MONDO:0003218" }, { "id": 5173, "label": "gastroesophageal junction adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712, 7738 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4944", "MEDGEN:231030", "NCIT:C9296", "ONCOTREE:EGC", "ONCOTREE:GEJ", "UMLS:C1332166" ], "synonyms": [ "adenocarcinoma - GEJ", "adenocarcinoma of cardioesophageal junction", "adenocarcinoma of gastroesophageal junction", "adenocarcinoma of the EG junction", "adenocarcinoma of the GE junction", "adenocarcinoma of the cardioesophageal junction", "adenocarcinoma of the esophagogastric junction", "adenocarcinoma of the gastroesophageal junction", "esophagogastric junction adenocarcinoma", "gastroesophageal junction adenocarcinoma", "esophagogastric adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the esophagogastric junction." }, "child_count": 0, "reference_id": "MONDO:0003219" }, { "id": 6144, "label": "maxillary sinus adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3934, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:7684", "GARD:0023940", "MEDGEN:233167", "NCIT:C6240", "SCTID:707339009", "UMLS:C1334642" ], "synonyms": [ "adenocarcinoma of the maxillary sinus", "maxillary sinus adenocarcinoma" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "An adenocarcinoma that arises from the maxillary sinus. It is classified as intestinal-type or non-intestinal-type adenocarcinoma. Nasal obstruction and epistaxis are the presenting signs." }, "child_count": 0, "reference_id": "MONDO:0004328" }, { "id": 6700, "label": "mucinous adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 20031 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3030", "EFO:0000197", "ICDO:8480/3", "MEDGEN:2844", "MESH:D002288", "NCIT:C26712", "ONCOTREE:CEMU", "UMLS:C0007130", "icd11.foundation:529352875" ], "synonyms": [ "adenocarcinoma, mucinous, malignant", "colloid adenocarcinoma", "colloid carcinoma", "gelatinous adenocarcinoma", "gelatinous carcinoma", "mucin-producing adenocarcinoma (morphologic abnormality)", "mucinous adenocarcinoma", "mucinous carcinoma", "mucinuos carcinoma", "mucoid adenocarcinoma", "mucoid carcinoma", "mucous adenocarcinoma", "mucous carcinoma", "CEMU" ], "definition": "An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland." }, "child_count": 34, "reference_id": "MONDO:0004957" }, { "id": 6708, "label": "acinar cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3025", "EFO:0000216", "GARD:0008568", "ICDO:8550/3", "MEDGEN:61660", "MESH:D018267", "NCIT:C3768", "ONCOTREE:ACCC", "UMLS:C0206685", "icd11.foundation:1322159869" ], "synonyms": [ "acinar adenocarcinoma", "acinar carcinoma", "acinar cell adenocarcinoma", "acinar cell carcinoma", "acinar cell carcinoma (morphologic abnormality)", "acinic cell adenocarcinoma", "acinic cell carcinoma", "carcinoma of acinar cell", "carcinoma, acinar cell, malignant", "ACCC", "acinic cell tumor", "acinic cell tumour" ], "definition": "A carcinoma that arises from epithelial cells of the acinar cell" }, "child_count": 5, "reference_id": "MONDO:0004965" }, { "id": 6713, "label": "adenoid cystic carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080202", "EFO:0000231", "GARD:0005743", "ICDO:8200/3", "MEDGEN:41382", "MESH:D003528", "NCIT:C2970", "ONCOTREE:ACYC", "UMLS:C0010606", "icd11.foundation:2127202862" ], "synonyms": [ "adenocystic carcinoma", "adenoid cystic cancer", "adenoid cystic carcinoma", "cylindroid adenocarcinoma", "cribriform carcinoma", "cylindroma" ], "definition": "A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic." }, "child_count": 17, "reference_id": "MONDO:0004971" }, { "id": 6729, "label": "breast adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 3053, 6712, 6730 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3458", "EFO:0000304", "MEDGEN:167809", "NCIT:C5214", "UMLS:C0858252" ], "synonyms": [ "adenocarcinoma of breast", "adenocarcinoma of the breast", "breast adenocarcinoma", "mammary adenocarcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the breast" }, "child_count": 39, "reference_id": "MONDO:0004988" }, { "id": 6742, "label": "clear cell adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4468", "EFO:0000348", "ICDO:8310/3", "MEDGEN:64629", "MESH:D018262", "NCIT:C3766", "UMLS:C0206681" ], "synonyms": [ "adenocarcinoma, clear cell, malignant", "clear cell adenocarcinoma", "clear cell adenocarcinoma (morphologic abnormality)", "clear cell adenocarcinoma NOS (morphologic abnormality)", "mesonephroma NOS (morphologic abnormality)", "water-clear cell adenocarcinoma (morphologic abnormality)", "Wolffian duct neoplasm", "clear cell carcinoma", "malignant mesonephroma", "mesonephroid clear cell adenocarcinoma", "mesonephroid clear cell carcinoma", "mesonephroma, malignant", "mesonephroma, malignant (morphologic abnormality)", "water-clear cell carcinoma" ], "definition": "A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid." }, "child_count": 11, "reference_id": "MONDO:0005004" }, { "id": 6746, "label": "colorectal adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 21360 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050861", "DOID:0050913", "EFO:0000365", "MEDGEN:230816", "NCIT:C5105", "ONCOTREE:COADREAD", "SCTID:408645001", "UMLS:C1319315" ], "synonyms": [ "adenocarcinoma of large bowel", "adenocarcinoma of large intestine", "adenocarcinoma of the large bowel", "adenocarcinoma of the large intestine", "colorectal (colon or rectal) adenocarcinoma", "colorectal adenocarcinoma", "colorectum adenocarcinoma", "large bowel adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, "child_count": 10, "reference_id": "MONDO:0005008" }, { "id": 6760, "label": "endometrioid adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 3637, 6712 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0000466", "ICDO:8380/3", "MEDGEN:293976", "NCIT:C3769", "UMLS:C1569637" ], "synonyms": [ "endometrioid adenocarcinoma", "endometrioid carcinoma", "endometrioid carcinoma of female reproductive system", "endometrioid carcinoma of the female reproductive system", "female reproductive endometrioid carcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament." }, "child_count": 12, "reference_id": "MONDO:0005026" }, { "id": 6762, "label": "esophageal adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 18977 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4914", "EFO:0000478", "GARD:0016927", "MEDGEN:124636", "NCIT:C4025", "ONCOTREE:ESCA", "Orphanet:99976", "SCTID:276803003", "UMLS:C0279628", "icd11.foundation:829915640" ], "synonyms": [ "adenocarcinoma - esophagus", "adenocarcinoma - oesophagus", "adenocarcinoma of esophagus", "adenocarcinoma of oesophagus", "adenocarcinoma of the esophagus", "adenocarcinoma of the oesophagus", "esophageal adenocarcinoma", "esophagus adenocarcinoma", "oesophageal adenocarcinoma", "oesophagus adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor." }, "child_count": 6, "reference_id": "MONDO:0005028" }, { "id": 6770, "label": "gastric adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6695, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3717", "EFO:0000503", "GARD:0027713", "MEDGEN:82961", "NCIT:C4004", "ONCOTREE:STAD", "Orphanet:464463", "SCTID:408647009", "UMLS:C0278701", "icd11.foundation:1855471719" ], "synonyms": [ "adenocarcinoma - stomach", "adenocarcinoma of stomach", "adenocarcinoma of the stomach", "gastric (stomach) adenocarcinoma", "gastric adenocarcinoma", "stomach adenocarcinoma", "STAD" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the stomach" }, "child_count": 18, "reference_id": "MONDO:0005036" }, { "id": 6791, "label": "lung adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 6944 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3910", "EFO:0000571", "MEDGEN:57744", "MESH:C538231", "NCIT:C3512", "ONCOTREE:LUAD", "Orphanet:415268", "SCTID:254626006", "UMLS:C0152013" ], "synonyms": [ "adenocarcinoma of lung", "adenocarcinoma of the lung", "lung adenocarcinoma", "non-small cell lung adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor." }, "child_count": 22, "reference_id": "MONDO:0005061" }, { "id": 6810, "label": "prostate adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 6882 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2526", "EFO:0000673", "MEDGEN:764", "NCIT:C2919", "ONCOTREE:PRAD", "SCTID:399490008", "UMLS:C0007112" ], "synonyms": [ "adenocarcinoma of prostate", "adenocarcinoma of the prostate", "prostate adenocarcinoma", "prostate gland adenocarcinoma", "prad" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the prostate gland" }, "child_count": 4, "reference_id": "MONDO:0005082" }, { "id": 6814, "label": "renal cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 6923 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4450", "EFO:0000681", "GARD:0013215", "HP:0005584", "ICD9:189.0", "MEDGEN:766", "MESH:D002292", "MedDRA:10067946", "NANDO:2200045", "NORD:1657", "ONCOTREE:RCC", "Orphanet:217071", "SCTID:702391001", "UMLS:C0007134" ], "synonyms": [ "RCC", "renal cell carcinoma", "renal cell carcinoma (disease)", "kidney adenocarcinoma", "renal cell adenocarcinoma" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the kidney" }, "child_count": 22, "reference_id": "MONDO:0005086" }, { "id": 6819, "label": "signet ring cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3493", "EFO:0000698", "ICDO:8490/3", "MEDGEN:61663", "MESH:D018279", "NCIT:C3774", "UMLS:C0206696" ], "synonyms": [ "signet ring carcinoma NOS (morphologic abnormality)", "signet ring cell adenocarcinoma", "signet ring cell carcinoma", "signet ring cell carcinoma (morphologic abnormality)" ], "definition": "A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland." }, "child_count": 11, "reference_id": "MONDO:0005092" }, { "id": 6877, "label": "cervical adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 6855 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3702", "EFO:0001416", "GARD:0020488", "MEDGEN:79024", "NCIT:C4029", "ONCOTREE:CEAD", "Orphanet:213772", "SCTID:254887002", "UMLS:C0279672", "icd11.foundation:261293318" ], "synonyms": [ "adenocarcinoma - cervix", "adenocarcinoma of cervix", "adenocarcinoma of cervix uteri", "adenocarcinoma of the cervix", "adenocarcinoma of the cervix uteri", "adenocarcinoma of the uterine cervix", "adenocarcinoma of uterine cervix", "cervical adenocarcinoma", "cervix adenocarcinoma", "cervix uteri adenocarcinoma", "uterine cervix adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type." }, "child_count": 20, "reference_id": "MONDO:0005153" }, { "id": 6974, "label": "serous adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3114", "EFO:0003825", "NCIT:C40101" ], "synonyms": [ "serous adenocarcinoma", "serous carcinoma", "serous cystadenocarcinoma", "serous cystadenocarcinoma, NOS (morphologic abnormality)" ], "definition": "An adenocarcinoma that is characterized by the presence of papillary patterns and cellular budding. Psammoma bodies may be present. Representative examples include cervical serous adenocarcinoma, endometrial serous adenocarcinoma, ovarian serous adenocarcinoma, and primary peritoneal serous adenocarcinoma." }, "child_count": 6, "reference_id": "MONDO:0005278" }, { "id": 7120, "label": "endometrium adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4530, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2870", "EFO:0005232", "MEDGEN:218862", "NCIT:C7359", "UMLS:C1153706" ], "synonyms": [ "endometrioid carcinoma of endometrium", "adenocarcinoma of endometrium", "adenocarcinoma of the endometrium", "adenocarcinoma, endometrial, malignant", "endometrial adenocarcinoma", "endometrioid adenoma or carcinoma NOS (morphologic abnormality)", "endometrioid adenomas and carcinomas (morphologic abnormality)", "endometrium adenocarcinoma", "endometrial endometrioid adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma." }, "child_count": 18, "reference_id": "MONDO:0005461" }, { "id": 7178, "label": "sweat gland carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4329, 6712, 8398 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5667", "EFO:0005591", "ICDO:8400/3", "MEDGEN:234685", "NCIT:C6938", "ONCOTREE:AECA", "UMLS:C1412016" ], "synonyms": [ "carcinoma of sweat gland", "carcinoma of the sweat gland", "carcinoma, sweat gland, malignant", "sweat gland carcinoma", "sweat gland carcinoma/apocrine eccrine carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma." }, "child_count": 12, "reference_id": "MONDO:0005524" }, { "id": 7240, "label": "cystadenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 20318 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3111", "EFO:0006387", "ICDO:8440/3", "MEDGEN:41385", "MESH:D003536", "NCIT:C2971", "UMLS:C0010631" ], "synonyms": [ "cystadenocarcinoma", "cystadenocarcinoma (morphologic abnormality)", "cystadenocarcinoma NOS (morphologic abnormality)", "cystadenocarcinoma, malignant" ], "definition": "A malignant cystic epithelial neoplasm arising from the glandular epithelium. The malignant epithelial cells invade the stroma. The cystic spaces contain serous or mucinous fluid. Representative examples include ovarian and pancreatic cystadenocarcinomas." }, "child_count": 12, "reference_id": "MONDO:0005596" }, { "id": 7247, "label": "tubular adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4929", "EFO:0006500", "ICDO:8211/3", "MEDGEN:61428", "NCIT:C65192", "UMLS:C0205645" ], "synonyms": [ "carcinoma, tubular cell, malignant", "tubular adenocarcinoma", "tubular adenocarcinoma (morphologic abnormality)" ], "definition": "An infiltrating adenocarcinoma in which the malignant cells form tubular structures. Representative examples include the tubular breast carcinoma and the gastric tubular adenocarcinoma." }, "child_count": 4, "reference_id": "MONDO:0005606" }, { "id": 7253, "label": "mesonephric adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0006719", "ICDO:9110/3", "MEDGEN:44373", "NCIT:C4072", "UMLS:C0025490" ], "synonyms": [ "malignant mesonephroma" ], "definition": "An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants." }, "child_count": 1, "reference_id": "MONDO:0005613" }, { "id": 7547, "label": "scirrhous adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712, 20678 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4024", "EFO:0007478", "ICDO:8141/3", "MEDGEN:2873", "MESH:D002293", "NCIT:C2928", "UMLS:C0007135" ], "synonyms": [ "FIBROADENOCARCINOMA, malignant", "adenocarcinoma with productive fibrosis", "fibrocarcinoma", "scirrhous adenocarcinoma", "scirrhous adenocarcinoma (morphologic abnormality)", "scirrhous carcinoma" ], "categories": [ { "ref": "MONDO:0003900", "name": "connective tissue disorder" } ], "definition": "An infiltrating adenocarcinoma characterized by the presence of desmoplastic stromal reaction." }, "child_count": 0, "reference_id": "MONDO:0005953" }, { "id": 7633, "label": "pancreatic adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 6912 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4074", "EFO:1000044", "GARD:0027736", "MEDGEN:83800", "NCIT:C8294", "ONCOTREE:PAAD", "SCTID:700423003", "UMLS:C0281361", "icd11.foundation:1663659989" ], "synonyms": [ "adenocarcinoma - pancreas", "adenocarcinoma of pancreas", "adenocarcinoma of the pancreas", "pancreas adenocarcinoma", "pancreatic adenocarcinoma", "PAAD" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the pancreas" }, "child_count": 10, "reference_id": "MONDO:0006047" }, { "id": 7767, "label": "follicular variant thyroid gland papillary carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000261", "MEDGEN:811427", "NCIT:C126594", "UMLS:C3714651" ], "synonyms": [ "FVPTC" ], "definition": "A nonencapsulated variant of papillary carcinoma of the thyroid gland characterized by the predominance of follicular structures. The malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland." }, "child_count": 0, "reference_id": "MONDO:0006214" }, { "id": 7768, "label": "gallbladder adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 5174, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3500", "EFO:1000262", "GARD:0024333", "MEDGEN:76009", "NCIT:C9166", "UMLS:C0279651", "icd11.foundation:15874829" ], "synonyms": [ "adenocarcinoma of gallbladder", "adenocarcinoma of the gallbladder", "gall bladder adenocarcinoma", "gallbladder adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from glandular epithelial cells of the gall bladder." }, "child_count": 8, "reference_id": "MONDO:0006215" }, { "id": 7793, "label": "hepatoid adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060534", "EFO:1000293", "ICDO:8576/3", "MEDGEN:220413", "NCIT:C66950", "UMLS:C1266090" ], "synonyms": [ "hepatoid adenocarcinoma", "hepatoid carcinoma" ], "definition": "An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver." }, "child_count": 1, "reference_id": "MONDO:0006243" }, { "id": 7801, "label": "intestinal type adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000304", "ICDO:8144/3", "MEDGEN:87206", "NCIT:C4126", "UMLS:C0334279" ], "synonyms": [ "intestinal type carcinoma", "intestinal-type adenocarcinoma" ], "definition": "An adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. Representative examples include gastric, gallbladder, and ampulla of Vater intestinal type adenocarcinomas." }, "child_count": 2, "reference_id": "MONDO:0006254" }, { "id": 7841, "label": "micropapillary serous carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000377", "MEDGEN:825423", "NCIT:C6882", "UMLS:C3839578" ], "definition": "An adenocarcinoma characterized by the presence of complex micropapillary structures covered by round and cuboidal cells with a high nuclear to cytoplasmic ratio." }, "child_count": 0, "reference_id": "MONDO:0006302" }, { "id": 7843, "label": "minor salivary gland adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 23549 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000379", "GARD:0027747", "MEDGEN:235328", "NCIT:C5948", "UMLS:C1334768" ], "synonyms": [ "adenocarcinoma of minor salivary gland", "adenocarcinoma of the minor salivary gland" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "An adenocarcinoma that arises from the minor salivary glands." }, "child_count": 2, "reference_id": "MONDO:0006304" }, { "id": 7903, "label": "poorly differentiated thyroid gland carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3972", "EFO:1000489", "ICDO:8337/3", "MEDGEN:266094", "NCIT:C6040", "ONCOTREE:THPD", "UMLS:C1266050", "icd11.foundation:1227619262" ], "synonyms": [ "insular carcinoma", "poorly differentiated carcinoma of the thyroid gland", "poorly differentiated carcinoma of thyroid gland", "poorly differentiated thyroid carcinoma", "poorly differentiated thyroid gland cancer", "poorly differentiated thyroid gland carcinoma", "thyroid gland poorly differentiated carcinoma", "poorly differentiated thyroid cancer" ], "definition": "An adenocarcinoma arising from the thyroid gland showing only limited evidence of follicular cell differentiation. Microscopically, the adenocarcinoma cells are arranged in insular, solid, and trabecular patterns. There is associated necrosis, and vascular invasion. The prognosis depends on the tumor stage, complete or partial surgical removal of the tumor, and the degree of response to radioactive iodine therapy (adapted from WHO Tumors of Endocrine Organs, IARC Press, Lyon 2004)" }, "child_count": 0, "reference_id": "MONDO:0006382" }, { "id": 7921, "label": "salivary gland basal cell adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2972, 6712, 7027 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000515", "GARD:0024399", "ICDO:8147/3", "MEDGEN:412203", "NCIT:C3678", "UMLS:C2243086" ], "synonyms": [ "basal cell adenocarcinoma", "basal cell adenocarcinoma of salivary gland", "basal cell adenocarcinoma of the salivary gland", "saliva-secreting gland skin basal cell carcinoma", "salivary gland basal cell adenocarcinoma", "skin basal cell carcinoma of saliva-secreting gland" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A rare adenocarcinoma of the major and minor salivary glands, originating from basaloid, myoepithelial and ductal cells. While morphologically resembling basal cell carcinomas, it is a distinct entity. The tumor is not encapsulated, may invade locally, and less frequently may metastasize. It usually occurs in older patients." }, "child_count": 0, "reference_id": "MONDO:0006402" }, { "id": 7948, "label": "submandibular gland adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6500, 6712 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000554", "GARD:0027756", "MEDGEN:234370", "NCIT:C5940", "UMLS:C1336521" ], "synonyms": [ "adenocarcinoma of submandibular gland", "adenocarcinoma of the submandibular gland", "submandibular gland adenocarcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "An adenocarcinoma that arises from the submandibular gland. Representative examples include polymorphic low-grade adenocarcinoma and acinic cell carcinoma." }, "child_count": 0, "reference_id": "MONDO:0006435" }, { "id": 8388, "label": "sebaceous adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 8398, 22966 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4839", "DOID:4840", "EFO:1001171", "ICDO:8410/3", "MEDGEN:64632", "MESH:D018266", "NCIT:C40310", "ONCOTREE:SEBA", "SCTID:307599002", "UMLS:C0206684" ], "synonyms": [ "adenocarcinoma, sebaceous, malignant", "carcinoma of sebaceous gland", "carcinoma of the sebaceous gland", "sebaceous cancer", "sebaceous carcinoma", "sebaceous gland adenocarcinoma", "sebaceous gland carcinoma", "malignant sebaceous tumor", "malignant sebaceous tumour", "Seba" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "An adenocarcinoma with sebaceous differentiation. It presents as a painless mass and it may be multifocal. It grows in the ocular adnexae and in the skin of head and neck, trunk, genitals, and extremities. It is characterized by the presence of malignant cells with multivesicular and clear cytoplasm. It may recur and metastasize." }, "child_count": 9, "reference_id": "MONDO:0006962" }, { "id": 8660, "label": "hepatocellular carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 18551 ], "type_id": 0, "properties": { "xrefs": [ "DOID:684", "DOID:686", "EFO:0000182", "GARD:0016773", "ICD10CM:C22.0", "ICDO:8170/3", "MEDGEN:389187", "MESH:D006528", "MedDRA:10049010", "NANDO:2200047", "NCIT:C3099", "NORD:1907", "OMIM:114550", "ONCOTREE:HCC", "Orphanet:88673", "UMLS:C2239176", "icd11.foundation:1294035808" ], "synonyms": [ "HCC", "cancer, hepatocellular", "carcinoma of liver", "carcinoma of liver cells", "carcinoma of the liver cells", "carcinoma, hepatocellular, malignant", "hepatoblastoma, somatic", "hepatocellular adenocarcinoma", "hepatocellular cancer", "hepatocellular cancer, somatic", "hepatocellular carcinoma", "hepatocellular carcinoma, childhood type, somatic", "hepatocellular carcinoma, somatic", "hepatoma", "liver carcinoma", "liver cell cancer (hepatocellular carcinoma)", "liver cell carcinoma", "primary carcinoma of liver cells", "primary carcinoma of the liver cells", "adult hepatoma", "adult primary hepatocellular carcinoma", "hepatoblastoma", "hepatoblastoma caused by somatic mutation", "liver and intrahepatic bile duct carcinoma", "liver cancer" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, "child_count": 16, "reference_id": "MONDO:0007256" }, { "id": 13075, "label": "parathyroid gland carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 5714, 6712, 20493 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1540", "EFO:1000456", "GARD:0007329", "MEDGEN:146361", "NCIT:C4906", "OMIM:608266", "ONCOTREE:PTHC", "Orphanet:143", "SCTID:255037004", "UMLS:C0687150" ], "synonyms": [ "cancer of parathyroid gland", "cancer of the parathyroid gland", "malignant neoplasm of parathyroid gland", "malignant neoplasm of the parathyroid", "malignant tumour of parathyroid gland", "parathyroid cancer", "parathyroid gland cancer", "parathyroid gland neoplasm", "parathyroid neoplasm", "adenocarcinoma of parathyroid", "adenocarcinoma of parathyroid gland", "adenocarcinoma of the parathyroid", "adenocarcinoma of the parathyroid gland", "carcinoma of parathyroid", "carcinoma of parathyroid gland", "carcinoma of the parathyroid", "carcinoma of the parathyroid gland", "parathyroid adenocarcinoma", "parathyroid carcinoma", "parathyroid gland adenocarcinoma", "parathyroid gland carcinoma", "PRTC" ], "categories": [ { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A very rare, slow-growing, clinically serious endocrine tumor that generally develops in mid-adulthood. PRTC presents as a palpable painless mass in the neck and causes severe hypercalcemia and related symptoms, non-specific gastrointestinal manifestations, as well as renal and bone complications related to primary hyperparathyroidism (nephrolithiasis, impaired renal function, osteoporosis, bone pain, and pathologic fractures, etc.). Some PRTCs are however non-functioning tumors." }, "child_count": 0, "reference_id": "MONDO:0012004" }, { "id": 17862, "label": "pituitary adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4185, 4246, 4505, 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4916", "GARD:0009371", "HP:0011763", "ICDO:8272/3", "MEDGEN:91096", "NCIT:C4536", "ONCOTREE:PTCA", "Orphanet:300385", "SCTID:254955001", "UMLS:C0346300" ], "synonyms": [ "cancer of pituitary", "cancer of pituitary gland", "cancer of the pituitary", "cancer of the pituitary gland", "pituitary gland cancer", "carcinoma of pituitary", "carcinoma of pituitary gland", "carcinoma of the pituitary", "carcinoma of the pituitary gland", "pituitary adenocarcinoma (disease)", "pituitary carcinoma", "pituitary gland adenocarcinoma", "pituitary gland carcinoma", "PTCA" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly." }, "child_count": 12, "reference_id": "MONDO:0017582" }, { "id": 20067, "label": "vaginal adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 3892, 6712, 16597 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025199", "MEDGEN:124643", "NCIT:C7981", "ONCOTREE:VA", "UMLS:C0279668" ], "synonyms": [ "adenocarcinoma of the vagina", "adenocarcinoma of vagina", "vagina adenocarcinoma", "vaginal adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "An adenocarcinoma arising from the vagina. Morphologic variants include the clear cell, endometrioid, mesonephric, and mucinous adenocarcinoma." }, "child_count": 3, "reference_id": "MONDO:0020653" }, { "id": 20398, "label": "Paget disease", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:277958", "NCIT:C7073", "UMLS:C1368019" ], "synonyms": [ "Paget cell neoplasm", "Paget disease", "Paget's cell neoplasm", "Paget's disease" ], "definition": "A malignant neoplasm composed of large cells with large nuclei, prominent nucleoli, and abundant pale cytoplasm (Paget cells). Paget cell neoplasms include Paget disease of the nipple and extramammary Paget disease which may affect the vulva, penis, anus, skin and scrotum." }, "child_count": 5, "reference_id": "MONDO:0021165" }, { "id": 20704, "label": "diffuse type adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "ICDO:8145/3", "MEDGEN:87207", "NCIT:C4127", "UMLS:C0334280" ], "synonyms": [ "diffuse type adenocarcinoma", "diffuse type carcinoma" ], "definition": "An adenocarcinoma characterized by the presence of a diffuse cellular infiltrate which is composed of poorly cohesive cells with minimal or no glandular formations. Representative example is the gastric diffuse adenocarcinoma." }, "child_count": 1, "reference_id": "MONDO:0021652" }, { "id": 21365, "label": "vulvar adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4321, 6712, 6931 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2098", "GARD:0022007", "MEDGEN:234480", "NCIT:C6380", "Orphanet:494454", "UMLS:C1336975" ], "synonyms": [ "adenocarcinoma of the vulva", "adenocarcinoma of vulva", "mammalian vulva adenocarcinoma", "vulva adenocarcinoma", "vulvar adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "An adenocarcinoma that arises from the vulva. Representative examples include Bartholin gland adenocarcinoma, eccrine adenocarcinoma, apocrine adenocarcinoma, and sebaceous carcinoma." }, "child_count": 21, "reference_id": "MONDO:0024336" }, { "id": 21537, "label": "thyroid gland adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6712, 16049 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080524", "GARD:0025440", "MEDGEN:309935", "NCIT:C27380", "UMLS:C1704228" ], "synonyms": [ "thyroid adenocarcinoma", "thyroid gland adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation)." }, "child_count": 6, "reference_id": "MONDO:0024622" }, { "id": 25158, "label": "gastroesophageal adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6712 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080375" ] }, "child_count": 0, "reference_id": "MONDO:0850130" }, { "id": 29304, "label": "adenoacanthoma", "isLeaf": true, "isRoot": false, "parents": [ 6712, 7464 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:90777", "UMLS:C0334393" ], "synonyms": [ "adenoacanthoma", "adenocarcinoma with squamous metaplasia" ], "definition": "An invasive adenocarcinoma characterized by the presence of focal or extensive transformation of malignant glandular cells to squamous epithelial cells." }, "child_count": 0, "reference_id": "MONDO:1060121" } ], "roots": [ { "id": 6734, "label": "carcinoma" }, { "id": 21312, "label": "glandular cell neoplasm" } ] }