{
  "id": 6713,
  "label": "adenoid cystic carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004971",
  "properties": {
    "xrefs": [
      "DOID:0080202",
      "EFO:0000231",
      "GARD:0005743",
      "ICDO:8200/3",
      "MEDGEN:41382",
      "MESH:D003528",
      "NCIT:C2970",
      "ONCOTREE:ACYC",
      "UMLS:C0010606",
      "icd11.foundation:2127202862"
    ],
    "synonyms": [
      "adenocystic carcinoma",
      "adenoid cystic cancer",
      "adenoid cystic carcinoma",
      "cylindroid adenocarcinoma",
      "cribriform carcinoma",
      "cylindroma"
    ],
    "definition": "A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 17,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    }
  ],
  "children": [
    {
      "id": 3100,
      "label": "lymph node adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3334,
        6713
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060219",
          "GARD:0022818"
        ],
        "synonyms": [
          "lymph node adenoid cystic carcinoma",
          "lymph node adenoid cystic cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A adenoid cystic carcinoma that involves the lymph node."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000715"
    },
    {
      "id": 5139,
      "label": "salivary gland adenoid cystic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2972,
        6713
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4866",
          "GARD:0023398",
          "MEDGEN:79034",
          "NCIT:C8026",
          "SCTID:422833009",
          "UMLS:C0279751"
        ],
        "synonyms": [
          "adenoid cystic cancer",
          "adenoid cystic carcinoma (morphologic abnormality)",
          "adenoid cystic carcinoma of salivary gland",
          "adenoid cystic carcinoma of the salivary gland",
          "cylindroma (morphologic abnormality)",
          "saliva-secreting gland adenoid cystic carcinoma",
          "salivary gland adenoid cystic cancer",
          "salivary gland adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An adenoid cystic carcinoma arising from the salivary gland. It is characterized by the presence of epithelial and myoepithelial cells forming tubular, cribriform, and solid patterns. It usually presents as a slow growing mass. Patients may experience pain because of the tumor propensity for perineural invasion. The tumor may follow an aggressive clinical course with recurrences and mestastases to distant sites including lungs, bones, brain, and liver."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003175"
    },
    {
      "id": 5140,
      "label": "prostate adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6810
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4868",
          "GARD:0023399",
          "MEDGEN:233352",
          "NCIT:C5539",
          "UMLS:C1335502"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of prostate",
          "adenoid cystic carcinoma of the prostate",
          "prostate adenoid cystic carcinoma",
          "prostate gland adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenoid cystic carcinoma that arises from the prostate gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003177"
    },
    {
      "id": 5141,
      "label": "cutaneous adenocystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        7178
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4871",
          "GARD:0023400",
          "MEDGEN:91071",
          "NCIT:C4471",
          "SCTID:254711000",
          "UMLS:C0346017"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of skin",
          "adenoid cystic carcinoma of the skin",
          "adenoid cystic cutaneous carcinoma",
          "adenoid cystic eccrine carcinoma (morphologic abnormality)",
          "adenoid cystic skin carcinoma",
          "primary cutaneous adenocystic carcinoma",
          "skin of body adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A adenoid cystic carcinoma that involves the skin of body."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003180"
    },
    {
      "id": 5142,
      "label": "lung adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4872",
          "GARD:0023401",
          "ICD9:162.9",
          "MEDGEN:232709",
          "NCIT:C5666",
          "ONCOTREE:LUACC",
          "SCTID:707466008",
          "UMLS:C1334439"
        ],
        "synonyms": [
          "adenocystic carcinoma of lung",
          "adenocystic carcinoma of the lung",
          "adenoid cystic carcinoma of lung",
          "adenoid cystic carcinoma of the lung",
          "lung adenocystic carcinoma",
          "lung adenoid cystic cancer",
          "lung adenoid cystic carcinoma",
          "pulmonary adenocystic carcinoma",
          "pulmonary adenoid cystic carcinoma",
          "LUACC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare usually indolent lung carcinoma characterized by a cribiform and tubular pattern and the presence of glandular epithelial cells. Clinical symptoms include shortness of breath, cough, wheeze, hemopytsis and chest pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003181"
    },
    {
      "id": 5145,
      "label": "adenoid cystic breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6729,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4877",
          "EFO:1000071",
          "GARD:0023402",
          "MEDGEN:231031",
          "NCIT:C5130",
          "ONCOTREE:ACBC",
          "UMLS:C1332167"
        ],
        "synonyms": [
          "adenocystic breast carcinoma",
          "adenocystic carcinoma of breast",
          "adenocystic carcinoma of the breast",
          "adenoid cystic breast carcinoma",
          "adenoid cystic carcinoma of breast",
          "adenoid cystic carcinoma of the breast",
          "breast adenoid cystic carcinoma",
          "mammary adenocystic carcinoma",
          "mammary adenoid cystic carcinoma",
          "adenoid cystic breast cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An adenoid cystic carcinoma primarily involving the breast. Three morphologic patterns are seen: cribriform, trabecular, and solid. The prognosis is excellent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003185"
    },
    {
      "id": 5146,
      "label": "esophageal adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4878",
          "GARD:0023403",
          "MEDGEN:232468",
          "NCIT:C5342",
          "UMLS:C1333441"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of esophagus",
          "adenoid cystic carcinoma of oesophagus",
          "adenoid cystic carcinoma of the esophagus",
          "adenoid cystic carcinoma of the oesophagus",
          "adenoid cystic carcinoma, esophagus",
          "adenoid cystic carcinoma, oesophagus",
          "adenoid cystic esophagus carcinoma",
          "adenoid cystic oesophagus carcinoma",
          "esophageal adenoid cystic cancer",
          "esophageal adenoid cystic carcinoma",
          "esophagus adenoid cystic carcinoma",
          "oesophagus adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An infrequent esophageal carcinoma arising from esophageal glands. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003186"
    },
    {
      "id": 5147,
      "label": "Bartholin gland adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5720,
        6713
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4879",
          "GARD:0023404",
          "MEDGEN:307247",
          "NCIT:C40295",
          "UMLS:C1511047"
        ],
        "synonyms": [
          "Bartholin gland adenoid cystic carcinoma",
          "Bartholin's gland adenoid cystic carcinoma",
          "major vestibular gland adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the Bartholin gland and is characterized by the presence of islands of uniform malignant cells forming cribriform patterns."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003187"
    },
    {
      "id": 7697,
      "label": "cervical adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4867",
          "EFO:1000161",
          "GARD:0020498",
          "MEDGEN:232337",
          "NCIT:C6346",
          "ONCOTREE:CACC",
          "Orphanet:213823",
          "UMLS:C1332911"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of cervix",
          "adenoid cystic carcinoma of cervix uteri",
          "adenoid cystic carcinoma of the cervix",
          "adenoid cystic carcinoma of the cervix uteri",
          "adenoid cystic carcinoma of the uterine cervix",
          "adenoid cystic carcinoma of uterine cervix",
          "cervical adenoid cystic cancer",
          "cervical adenoid cystic carcinoma",
          "cervix uteri adenoid cystic carcinoma",
          "uterine cervix adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare carcinoma that arises from the cervix. It is characterized by the presence of cystic spaces surrounded by palisaded epithelial cells. The cystic spaces contain eosinophilic hyaline material or mucin. Nuclear pleomorphism, necrotic changes, and a high mitotic rate are also present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006133"
    },
    {
      "id": 7807,
      "label": "lacrimal gland adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4555,
        6713
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4870",
          "EFO:1000317",
          "GARD:0024350",
          "MEDGEN:87555",
          "NCIT:C4540",
          "SCTID:254987003",
          "UMLS:C0346340"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of lacrimal gland",
          "adenoid cystic carcinoma of the lacrimal gland",
          "lacrimal gland adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A adenoid cystic carcinoma that involves the lacrimal gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006262"
    },
    {
      "id": 7808,
      "label": "laryngeal adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4457,
        6713
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4869",
          "EFO:1000319",
          "GARD:0024351",
          "MEDGEN:232690",
          "NCIT:C9462",
          "UMLS:C1334368"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of larynx",
          "adenoid cystic carcinoma of the larynx",
          "laryngeal adenoid cystic carcinoma",
          "laryngeal throat adenoid cystic cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare adenoid cystic carcinoma of the larynx. It usually arises from the supraglottic or subglottic area. It is characterized by slow progression and late distant metastases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006264"
    },
    {
      "id": 7878,
      "label": "paranasal sinus adenoid cystic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2879,
        6713
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024379",
          "MEDGEN:233840",
          "NCIT:C6019",
          "UMLS:C1335337"
        ],
        "synonyms": [
          "accessory sinus adenoid cystic carcinoma",
          "adenoid cystic carcinoma of accessory sinus",
          "adenoid cystic carcinoma of paranasal sinus",
          "adenoid cystic carcinoma of the accessory sinus",
          "adenoid cystic carcinoma of the paranasal sinus",
          "paranasal sinus adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare adenoid cystic carcinoma that arises from the paranasal sinuses. It usually has an aggressive clinical course characterized by high recurrence rates and distant metastases."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006352"
    },
    {
      "id": 7892,
      "label": "pharyngeal adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4185,
        6713,
        7172,
        20516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024384",
          "MEDGEN:233324",
          "NCIT:C5818",
          "UMLS:C1335399"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of pharynx",
          "adenoid cystic carcinoma of the pharynx",
          "pharyngeal adenoid cystic carcinoma",
          "pharyngeal throat adenoid cystic cancer",
          "pharynx adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "An adenoid cystic carcinoma that arises from the pharynx."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006367"
    },
    {
      "id": 7971,
      "label": "tracheal adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5144,
        6713
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4875",
          "EFO:1000598",
          "GARD:0024426",
          "MEDGEN:91058",
          "NCIT:C6051",
          "SCTID:254619006",
          "UMLS:C0345945"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of the trachea",
          "adenoid cystic carcinoma of trachea",
          "trachea adenoid cystic carcinoma",
          "tracheal adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An adenoid cystic carcinoma that arises from the trachea. It spreads to the submucosal tracheal tissue and to regional lymph nodes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006471"
    },
    {
      "id": 7984,
      "label": "vaginal adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        20067
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024431",
          "MEDGEN:274376",
          "NCIT:C40261",
          "UMLS:C1519912"
        ],
        "synonyms": [
          "vaginal adenoid cystic cancer",
          "vaginal adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenoid cystic carcinoma that arises from the vagina. Myoepithelial cells are usually not present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006487"
    },
    {
      "id": 16834,
      "label": "adenoid cystic carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6929,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:213741",
          "icd11.foundation:350868040"
        ],
        "synonyms": [
          "body of uterus adenoid cystic carcinoma",
          "endometrial adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A adenoid cystic carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016271"
    },
    {
      "id": 20488,
      "label": "adenoid cystic carcinoma of oropharynx",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        23484
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025310",
          "MEDGEN:235411",
          "NCIT:C6241",
          "SCTID:423318000",
          "UMLS:C1335139",
          "icd11.foundation:2053023791"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of the oropharynx",
          "oropharyngeal adenoid cystic carcinoma",
          "oropharyngeal throat adenoid cystic cancer",
          "oropharynx adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A adenoid cystic carcinoma that involves the oropharynx."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021300"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    }
  ]
}