{
  "id": 6716,
  "label": "adrenal gland pheochromocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004974",
  "properties": {
    "xrefs": [
      "DOID:0050892",
      "EFO:0000239",
      "GARD:0024140",
      "ICDO:8700/0",
      "MEDGEN:1636437",
      "NANDO:2200078",
      "NCIT:C3326",
      "UMLS:C4551683"
    ],
    "synonyms": [
      "pheochromocytoma",
      "Intraadrenal paraganglioma",
      "PCC",
      "adrenal gland Chromaffinoma",
      "adrenal gland chromaffin paraganglioma",
      "adrenal gland paraganglioma",
      "adrenal gland pheochromocytoma",
      "adrenal medullary paraganglioma",
      "adrenal medullary pheochromocytoma",
      "adrenal pheochromocytoma",
      "chromaffin paraganglioma of the adrenal gland",
      "pheochromocytoma (adrenal)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 20313,
      "label": "sympathetic paraganglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2912,
        7265,
        23497
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025286",
          "ICDO:8681/1",
          "MEDGEN:137758",
          "MESH:C531777",
          "NCIT:C4216",
          "SCTID:399343007",
          "UMLS:C0334415"
        ],
        "synonyms": [
          "Chromaffinoma",
          "chromaffin neoplasm",
          "chromaffin tumor",
          "chromaffin tumour",
          "paraganglioma of sympathetic nervous system",
          "sympathetic Paraganglionic neoplasm",
          "sympathetic nervous system paraganglioma",
          "sympathetic paraganglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant paraganglioma arising from the chromaffin cells of the paraganglia that are located along the sympathetic nerves. It includes extra-adrenal paragangliomas and paragangliomas that arise from the adrenal medulla. The latter are commonly referred to as pheochromocytomas. Representative examples of extra-adrenal sympathetic paragangliomas include the bladder, and superior and inferior paraaortic paragangliomas. Clinical signs are related to the secretion of catecholamines resulting in hypertension."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021072"
    },
    {
      "id": 20446,
      "label": "adrenal medulla neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025301",
          "MEDGEN:108572",
          "NCIT:C4856",
          "UMLS:C0596046"
        ],
        "synonyms": [
          "adrenal medulla neoplasm (disease)",
          "adrenal medulla tumor",
          "adrenal medulla tumour",
          "neoplasm of adrenal medulla",
          "tumor of adrenal medulla",
          "tumour of adrenal medulla"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the adrenal medulla."
      },
      "child_count": 3,
      "reference_id": "MONDO:0021237"
    }
  ],
  "children": [
    {
      "id": 7674,
      "label": "benign adrenal gland pheochromocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6716,
        20589,
        22952,
        23665
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000106",
          "GARD:0024293",
          "MEDGEN:317403",
          "NCIT:C48305",
          "UMLS:C1706920"
        ],
        "synonyms": [
          "adrenal gland pheochromocytoma, benign",
          "benign adrenal gland pheochromocytoma",
          "pheochromocytoma, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sporadic or familial pheochromocytoma that is confined to the adrenal gland and does not have any metastatic potential. The majority of cases are sporadic, and usually unilateral. Familial cases are usually bilateral."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006103"
    },
    {
      "id": 7831,
      "label": "malignant adrenal gland pheochromocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4255,
        4753,
        6024,
        6716,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080347",
          "EFO:1000348",
          "GARD:0024362",
          "ICDO:8700/3",
          "MEDGEN:87238",
          "NCIT:C4220",
          "SCTID:21851000119103",
          "UMLS:C0334419"
        ],
        "synonyms": [
          "adrenal gland pheochromocytoma, malignant",
          "malignant adrenal gland Chromaffinoma",
          "malignant adrenal gland chromaffin neoplasm",
          "malignant adrenal gland chromaffin paraganglioma",
          "malignant adrenal gland chromaffin tumor",
          "malignant adrenal gland chromaffin tumour",
          "malignant adrenal gland paraganglioma",
          "malignant adrenal gland pheochromocytoma",
          "malignant adrenal medullary paraganglioma",
          "malignant adrenal medullary pheochromocytoma",
          "malignant adrenal pheochromocytoma",
          "malignant pheochromocytoma",
          "pheochromoblastoma",
          "pheochromocytoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pheochromocytoma that metastasizes to other anatomic sites. Common sites of metastasis include lymph nodes, bones, liver, and lung. Morphologic features associated with malignant pheochromocytomas include: atypical mitotic figures, capsular and vascular invasion, tumor cell necrosis, and high mitotic activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006288"
    },
    {
      "id": 23430,
      "label": "childhood adrenal gland pheochromocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6716,
        20320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070325",
          "GARD:0025907",
          "GTR:AN0102113",
          "MEDGEN:859271",
          "NCIT:C118822",
          "UMLS:C3899677"
        ],
        "synonyms": [
          "childhood adrenal gland pheochromocytoma",
          "pheochromocytoma, childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare pheochromocytoma of the adrenal gland that occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044767"
    }
  ],
  "roots": [
    {
      "id": 20313,
      "label": "sympathetic paraganglioma"
    },
    {
      "id": 20446,
      "label": "adrenal medulla neoplasm"
    }
  ]
}