{
  "id": 6717,
  "label": "Alzheimer disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004975",
  "properties": {
    "xrefs": [
      "DOID:10652",
      "HP:0002511",
      "ICD10CM:G30",
      "ICD10WHO:G30",
      "ICD9:290.1",
      "ICD9:331.0",
      "MEDGEN:1853",
      "MESH:D000544",
      "NCIT:C2866",
      "Orphanet:238616",
      "SCTID:142811000119104",
      "UMLS:C0002395",
      "birnlex:2092",
      "icd11.foundation:1611724421"
    ],
    "synonyms": [
      "AD",
      "Alzheimer dementia",
      "Alzheimer disease",
      "Alzheimer's dementia",
      "Alzheimer's disease",
      "Alzheimers disease",
      "presenile and senile dementia",
      "Alzheimer disease, familial"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 3823,
      "label": "dementia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4186
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1307",
          "HP:0000726",
          "ICD10CM:F02",
          "ICD9:290.8",
          "ICD9:294.1",
          "ICD9:294.8",
          "MEDGEN:99229",
          "MESH:D003704",
          "NCIT:C4786",
          "SCTID:52448006",
          "UMLS:C0497327",
          "icd11.foundation:1468768235",
          "icd11.foundation:546689346"
        ],
        "synonyms": [
          "dementia",
          "dementia (disease)"
        ],
        "definition": "Loss of intellectual abilities interfering with an individual's social and occupational functions. Causes include Alzheimer's disease, brain injuries, brain tumors, and vascular disorders."
      },
      "child_count": 9,
      "reference_id": "MONDO:0001627"
    },
    {
      "id": 7220,
      "label": "tauopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        29384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:680",
          "EFO:0005815",
          "MEDGEN:181880",
          "MESH:D024801",
          "UMLS:C0949664"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (tau proteins) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with alzheimer disease; dementia; parkinsonian disorders; progressive supranuclear palsy (supranuclear palsy, progressive); and corticobasal degeneration."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005574"
    }
  ],
  "children": [
    {
      "id": 11582,
      "label": "Alzheimer disease 16",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6717
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110036",
          "MEDGEN:394384",
          "MESH:C567463",
          "OMIM:300756",
          "UMLS:C2677888"
        ],
        "synonyms": [
          "AD16",
          "Alzheimer disease 16",
          "Alzheimer's disease 16",
          "Alzheimer's disease type 16"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An Alzheimer's disease that is characterized by an associated with a risk allele in in the PCDH11X gene on chromosome Xq21.3."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010422"
    },
    {
      "id": 15046,
      "label": "Alzheimer disease 17",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6717,
        16360,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110049",
          "GARD:0027854",
          "MEDGEN:767366",
          "OMIM:615080",
          "UMLS:C3554452"
        ],
        "synonyms": [
          "AD17",
          "Alzheimer disease 17",
          "Alzheimer's disease 17",
          "Alzheimer's disease type 17",
          "Alzheimer disease 17, late-onset"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An Alzheimer's disease that is characterized by an associated with mutations in the gene TREM2."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014036"
    },
    {
      "id": 15270,
      "label": "Alzheimer disease 18",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6717,
        16360,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110050",
          "GARD:0024982",
          "MEDGEN:816371",
          "OMIM:615590",
          "UMLS:C3810041"
        ],
        "synonyms": [
          "AD18",
          "ADAM10 Alzheimer disease",
          "Alzheimer disease 18",
          "Alzheimer disease caused by mutation in ADAM10",
          "Alzheimer disease type 18",
          "Alzheimer's disease 18",
          "Alzheimer's disease type 18",
          "Alzheimer disease 18, late-onset",
          "Alzheimer disease 18, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any Alzheimer disease in which the cause of the disease is a mutation in the ADAM10 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014265"
    },
    {
      "id": 15319,
      "label": "Alzheimer disease 19",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6717
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110051",
          "GARD:0024983",
          "MEDGEN:816679",
          "OMIM:615711",
          "UMLS:C3810349"
        ],
        "synonyms": [
          "AD19",
          "Alzheimer disease 19",
          "Alzheimer disease caused by mutation in PLD3",
          "Alzheimer disease type 19",
          "Alzheimer's disease 19",
          "Alzheimer's disease type 19",
          "PLD3 Alzheimer disease",
          "Alzheimer disease 19, late-onset"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any Alzheimer disease in which the cause of the disease is a mutation in the PLD3 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014316"
    },
    {
      "id": 23839,
      "label": "familial Alzheimer disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6717,
        16360,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:82914",
          "UMLS:C0276496"
        ],
        "synonyms": [
          "Alzheimer disease, familial",
          "FAD",
          "GARD:0000632"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A degenerative disease of the brain that causes gradual loss of memory, judgment, and the ability to function socially. About 25% of all Alzheimer disease is familial (more than 2 people in a family have AD). When Alzheimer disease begins before 60 or 65 years of age (early-onset AD) about 60% of the cases are familial (also known as Early-onset familial AD). These cases appear to be inherited in an autosomal dominant manner."
      },
      "child_count": 6,
      "reference_id": "MONDO:0100087"
    }
  ],
  "roots": [
    {
      "id": 3823,
      "label": "dementia"
    },
    {
      "id": 7220,
      "label": "tauopathy"
    }
  ]
}