{
  "id": 6718,
  "label": "amyotrophic lateral sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004976",
  "properties": {
    "xrefs": [
      "DOID:332",
      "GARD:0005786",
      "HP:0007354",
      "ICD10CM:G12.21",
      "ICD9:335.20",
      "MEDGEN:274",
      "MESH:D000690",
      "MedDRA:10002026",
      "NANDO:1200002",
      "NCIT:C34373",
      "NORD:768",
      "Orphanet:803",
      "SCTID:86044005",
      "UMLS:C0002736",
      "birnlex:12566",
      "icd11.foundation:1982355687"
    ],
    "synonyms": [
      "ALS",
      "Charcot disease",
      "Lou Gehrig disease",
      "amyotrophic lateral sclerosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 5143,
      "label": "anterior horn disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4611
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4873",
          "ICD9:335",
          "MEDGEN:102314",
          "SCTID:85672005",
          "UMLS:C0154681"
        ],
        "synonyms": [
          "disease of ventral horn of spinal cord",
          "disease or disorder of ventral horn of spinal cord",
          "disorder of ventral horn of spinal cord",
          "ventral horn of spinal cord disease",
          "ventral horn of spinal cord disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anterior horn disease is one of a number of medical disorders affecting the anterior horn of the spinal cord. Anterior horn diseases include spinal muscular atrophy, poliomyelitis and amyotrophic lateral sclerosis."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003182"
    },
    {
      "id": 19749,
      "label": "motor neuron disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        18957
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:231",
          "EFO:0003782",
          "GARD:0019477",
          "ICD10CM:G12.2",
          "ICD9:335.2",
          "ICD9:335.8",
          "ICD9:335.9",
          "MEDGEN:38785",
          "MESH:D016472",
          "MedDRA:10028003",
          "Orphanet:98503",
          "SCTID:37340000",
          "UMLS:C0085084",
          "icd11.foundation:661720689"
        ],
        "synonyms": [
          "anterior horn cell disease",
          "disease of motor neuron",
          "disease or disorder of motor neuron",
          "disorder of motor neuron",
          "motor neuron disease",
          "motor neuron disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Neurological disease involving the motor neuron."
      },
      "child_count": 8,
      "reference_id": "MONDO:0020128"
    }
  ],
  "children": [
    {
      "id": 6868,
      "label": "familial amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6718,
        21302
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001356",
          "GARD:0024155",
          "MEDGEN:1642547",
          "OMIMPS:105400",
          "UMLS:C4551993"
        ],
        "synonyms": [
          "hereditary amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of amyotrophic lateral sclerosis that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005144"
    },
    {
      "id": 6869,
      "label": "sporadic amyotrophic lateral sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080917",
          "EFO:0001357",
          "GARD:0024156",
          "MEDGEN:400171",
          "UMLS:C1862941"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Sporadic amyotrophic lateral sclerosis is a amyotrophic lateral sclerosis in which there is no known cause, such as no family history."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005145"
    },
    {
      "id": 10054,
      "label": "amyotrophic lateral sclerosis with polyglucosan bodies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015138",
          "MEDGEN:347953",
          "MESH:C565955",
          "OMIM:205250",
          "UMLS:C1859805"
        ],
        "synonyms": [
          "amyotrophic lateral sclerosis with polyglucosan bodies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008782"
    },
    {
      "id": 18678,
      "label": "progressive muscular atrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:318",
          "GARD:0021891",
          "ICD9:335.21",
          "MEDGEN:906831",
          "NCIT:C85027",
          "Orphanet:454706",
          "SCTID:88923002",
          "UMLS:C4082951",
          "icd11.foundation:1282359533"
        ],
        "synonyms": [
          "PMA",
          "pure progressive muscular atrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare, milder form of amyotrophic lateral sclerosis. It is characterized by a slowly progressive clinical course. Signs and symptoms include muscle weakness, atrophy, and fasciculation."
      },
      "child_count": 1,
      "reference_id": "MONDO:0018687"
    }
  ],
  "roots": [
    {
      "id": 5143,
      "label": "anterior horn disorder"
    },
    {
      "id": 19749,
      "label": "motor neuron disorder"
    }
  ]
}