{
  "id": 6727,
  "label": "urinary bladder carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004986",
  "properties": {
    "xrefs": [
      "DOID:4007",
      "HP:0002862",
      "MEDGEN:147071",
      "NCIT:C4912",
      "SCTID:255108000",
      "UMLS:C0699885"
    ],
    "synonyms": [
      "bladder cancer",
      "cancer of bladder",
      "cancer of the bladder",
      "cancer of the urinary bladder",
      "cancer of urinary bladder",
      "urinary bladder cancer",
      "bladder carcinoma",
      "carcinoma bladder",
      "carcinoma of bladder",
      "carcinoma of the bladder",
      "carcinoma of the urinary bladder",
      "carcinoma of urinary bladder",
      "urinary bladder carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the urinary bladder"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 3431,
      "label": "urinary bladder cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6728,
        7836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11054",
          "ICD10CM:C67",
          "ICD9:188",
          "ICD9:188.8",
          "ICD9:188.9",
          "MEDGEN:14150",
          "NCIT:C9334",
          "OMIM:109800",
          "Orphanet:157980",
          "SCTID:399326009",
          "UMLS:C0005684",
          "icd11.foundation:1244512758"
        ],
        "synonyms": [
          "tumor of the bladder",
          "tumour of the bladder",
          "bladder cancer, somatic",
          "cancer of urinary bladder",
          "malignant bladder neoplasm",
          "malignant bladder tumor",
          "malignant bladder tumour",
          "malignant neoplasm of bladder",
          "malignant neoplasm of the bladder",
          "malignant neoplasm of the urinary bladder",
          "malignant neoplasm of urinary bladder",
          "malignant neoplasm, bladder",
          "malignant neoplasm, urinary bladder",
          "malignant tumor of bladder",
          "malignant tumor of the bladder",
          "malignant tumor of the urinary bladder",
          "malignant tumor of urinary bladder",
          "malignant tumor, urinary bladder",
          "malignant tumour of bladder",
          "malignant tumour of the bladder",
          "malignant tumour of the urinary bladder",
          "malignant tumour of urinary bladder",
          "malignant urinary bladder neoplasm",
          "malignant urinary bladder tumor",
          "malignant urinary bladder tumour",
          "urinary bladder cancer",
          "urinary bladder malignant neoplasm",
          "urinary bladder malignant tumor",
          "urinary bladder malignant tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the bladder."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001187"
    },
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 4786,
      "label": "bladder adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3711",
          "EFO:1000125",
          "MEDGEN:76014",
          "NCIT:C4032",
          "ONCOTREE:BLAD",
          "SCTID:255110003",
          "UMLS:C0279682"
        ],
        "synonyms": [
          "adenocarcinoma of bladder",
          "adenocarcinoma of the bladder",
          "adenocarcinoma of the urinary bladder",
          "adenocarcinoma of urinary bladder",
          "bladder adenocarcinoma",
          "urinary bladder adenocarcinoma",
          "blad"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the urinary bladder"
      },
      "child_count": 14,
      "reference_id": "MONDO:0002751"
    },
    {
      "id": 4794,
      "label": "bladder squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6727,
        6823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3742",
          "EFO:1000130",
          "MEDGEN:124645",
          "NCIT:C4031",
          "ONCOTREE:BLSC",
          "SCTID:255111004",
          "UMLS:C0279681"
        ],
        "synonyms": [
          "bladder epidermoid carcinoma",
          "bladder squamous cell cancer",
          "bladder squamous cell carcinoma",
          "epidermoid carcinoma of bladder",
          "epidermoid carcinoma of the bladder",
          "epidermoid carcinoma of the urinary bladder",
          "epidermoid carcinoma of urinary bladder",
          "squamous cell carcinoma of bladder",
          "squamous cell carcinoma of the bladder",
          "squamous cell carcinoma of the urinary bladder",
          "squamous cell carcinoma of urinary bladder",
          "urinary bladder epidermoid carcinoma",
          "urinary bladder squamous cell carcinoma",
          "BLSC"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the bladder arising from metaplastic epithelium. It represents less than 10% of bladder carcinomas. The exception is the Middle East along the Nile Valley, where it represents the most common form of carcinoma because of the endemic nature of schistosomiasis. Bladder squamous cell carcinoma is often associated with long-standing chronic inflammation of the bladder and usually has a poor prognosis. The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002760"
    },
    {
      "id": 5596,
      "label": "bladder urachal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5958",
          "MEDGEN:419015",
          "MESH:C536475",
          "NCIT:C39842",
          "ONCOTREE:URCA",
          "Orphanet:695020",
          "UMLS:C2931202"
        ],
        "synonyms": [
          "bladder urachal cancer",
          "bladder urachal carcinoma",
          "urachal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. The urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. This connection normally disappears before birth, but in some people remains. Urachalcancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder.Most urachal cancersare adenocarcinomas (cancers that develop from gland cells).Others may besarcomas (which develop from connective tissue -such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma), small cell carcinomas, transitional cell cancer, and mixed neoplasias. Most individuals with urachal cancer have symptoms of with hematuria (blood in urine). Other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. Treatment usually involved surgery to remove the cancer."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003715"
    },
    {
      "id": 5947,
      "label": "urinary bladder small cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        6727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7132",
          "EFO:1000129",
          "GARD:0011923",
          "MEDGEN:231950",
          "NCIT:C9461",
          "ONCOTREE:SCBC",
          "Orphanet:284400",
          "UMLS:C1332564"
        ],
        "synonyms": [
          "SCCB",
          "bladder small cell neuroendocrine cancer",
          "bladder small cell neuroendocrine carcinoma",
          "poorly differentiated neuroendocrine carcinoma of the bladder",
          "small cell bladder cancer",
          "small cell bladder carcinoma",
          "small cell carcinoma of the urinary bladder",
          "small cell carcinoma of urinary bladder",
          "small cell neuroendocrine carcinoma of the urinary bladder",
          "small cell neuroendocrine carcinoma of urinary bladder",
          "urinary bladder small cell carcinoma",
          "small cell carcinoma of the bladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A highly aggressive carcinoma, histologically resembling small cell lung carcinoma. In most cases it is associated with carcinoma in situ."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004114"
    },
    {
      "id": 6004,
      "label": "stage IVb bladder cancer",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7315",
          "MEDGEN:277737",
          "NCIT:C9368",
          "UMLS:C1336362"
        ],
        "synonyms": [
          "Jewett-Marshall stage D2 bladder cancer",
          "Jewett-Marshall stage D2 urinary bladder cancer",
          "Jewett-Marshall stage D2 urinary bladder carcinoma",
          "stage IVB bladder cancer",
          "stage IVB urinary bladder cancer",
          "stage IVB urinary bladder carcinoma",
          "Jewett-Marshall bladder cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004182"
    },
    {
      "id": 6022,
      "label": "superficial urinary bladder carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7371",
          "MEDGEN:234371",
          "NCIT:C27474",
          "SCTID:425231005",
          "UMLS:C1336527"
        ],
        "synonyms": [
          "superficial bladder cancer",
          "superficial bladder carcinoma",
          "superficial urinary bladder cancer",
          "superficial urinary bladder carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A term used by urologists to describe an infiltrating carcinoma of the bladder that has not invaded into the muscularis propria of the bladder wall regardless of histologic type or grade."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004200"
    },
    {
      "id": 7252,
      "label": "bladder transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6727,
        23006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4006",
          "EFO:0006544",
          "MEDGEN:76013",
          "NCIT:C39851",
          "ONCOTREE:BLCA",
          "SCTID:255109008",
          "UMLS:C0279680"
        ],
        "synonyms": [
          "bladder transitional cell carcinoma",
          "bladder urothelial cancer",
          "bladder urothelial carcinoma",
          "transitional cell carcinoma of the urinary bladder",
          "urinary bladder transitional cell carcinoma",
          "urinary bladder urothelial carcinoma",
          "urothelial carcinoma of the urinary bladder",
          "BLCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005611"
    },
    {
      "id": 20897,
      "label": "childhood bladder carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027906",
          "MEDGEN:859269",
          "NCIT:C118816",
          "UMLS:C3899675"
        ],
        "synonyms": [
          "bladder cancer",
          "childhood bladder cancer",
          "childhood bladder carcinoma",
          "bladder cancer childhood",
          "bladder cancer, childhood",
          "bladder carcinoma, childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare carcinoma of the bladder that occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022578"
    },
    {
      "id": 25210,
      "label": "bladder small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080902"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A bladder carcinoma that is characterized as an undifferentiated neoplasm composed of primitive-appearing cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850348"
    }
  ],
  "roots": [
    {
      "id": 3431,
      "label": "urinary bladder cancer"
    },
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}