{
  "id": 6730,
  "label": "breast carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004989",
  "properties": {
    "xrefs": [
      "DOID:3459",
      "EFO:0000305",
      "HP:0003002",
      "MEDGEN:146260",
      "NCIT:C4872",
      "SCTID:254838004",
      "UMLS:C0678222"
    ],
    "synonyms": [
      "breast cancer",
      "breast cancer, NOS",
      "cancer of breast",
      "cancer of the breast",
      "cancer, breast",
      "breast carcinoma",
      "carcinoma of breast",
      "carcinoma of the breast",
      "mammary carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the breast"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 8659,
      "label": "breast cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5215,
        20340
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1612",
          "ICD10CM:C50",
          "ICD9:174.8",
          "MEDGEN:651",
          "NCIT:C9335",
          "SCTID:254837009",
          "UMLS:C0006142",
          "icd11.foundation:1047754165"
        ],
        "synonyms": [
          "breast tumor",
          "breast tumour",
          "mammary tumor",
          "mammary tumour",
          "breast cancer",
          "cancer of breast",
          "malignant breast neoplasm",
          "malignant breast tumor",
          "malignant breast tumour",
          "malignant neoplasm of breast",
          "malignant neoplasm of the breast",
          "malignant tumor of breast",
          "malignant tumor of the breast",
          "malignant tumour of breast",
          "malignant tumour of the breast",
          "primary breast cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males."
      },
      "child_count": 12,
      "reference_id": "MONDO:0007254"
    }
  ],
  "children": [
    {
      "id": 5808,
      "label": "nipple carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        4562,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6629",
          "MEDGEN:233756",
          "NCIT:C28432",
          "UMLS:C1334966"
        ],
        "synonyms": [
          "carcinoma of nipple",
          "nipple cancer",
          "nipple carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the nipple"
      },
      "child_count": 6,
      "reference_id": "MONDO:0003950"
    },
    {
      "id": 5836,
      "label": "bilateral breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6741",
          "MEDGEN:128977",
          "NCIT:C8287",
          "UMLS:C0281267"
        ],
        "synonyms": [
          "bilateral breast cancer",
          "bilateral breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Carcinoma that affects both breasts in a simultaneous or non-simultaneous manner."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003982"
    },
    {
      "id": 6192,
      "label": "female breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050671",
          "DOID:7843",
          "ICD9:174.8",
          "ICD9:174.9",
          "MEDGEN:40099",
          "NCIT:C2918",
          "SCTID:372064008",
          "SCTID:447782002",
          "UMLS:C0007104"
        ],
        "synonyms": [
          "breast carcinoma, female",
          "carcinoma of female breast",
          "carcinoma of the female breast",
          "female breast cancer",
          "female breast carcinoma",
          "mammary carcinoma of female breast",
          "mammary carcinoma of the female breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from the breast in females. It is the most common malignant tumor that affects females."
      },
      "child_count": 7,
      "reference_id": "MONDO:0004379"
    },
    {
      "id": 6244,
      "label": "sporadic breast cancer",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8029",
          "MEDGEN:233463",
          "NCIT:C7566",
          "UMLS:C1336076"
        ],
        "synonyms": [
          "sporadic breast cancer",
          "sporadic breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from the breast and is not caused by inherited genetic mutations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004438"
    },
    {
      "id": 6442,
      "label": "breast carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8791",
          "ICD10CM:D05",
          "ICD9:233.0",
          "MEDGEN:57817",
          "MESH:D000071960",
          "NCIT:C3641",
          "SCTID:189336000",
          "UMLS:C0154084",
          "icd11.foundation:1264360394"
        ],
        "synonyms": [
          "breast cancer in situ",
          "breast cancer stage 0",
          "breast carcinoma in situ",
          "breast in situ carcinoma",
          "carcinoma in situ of breast",
          "carcinoma in situ of the breast",
          "in situ breast cancer",
          "non-infiltrating breast carcinoma",
          "non-infiltrating carcinoma of breast",
          "non-infiltrating carcinoma of the breast",
          "non-invasive breast carcinoma",
          "non-invasive carcinoma of breast",
          "non-invasive carcinoma of the breast",
          "stage 0 breast cancer",
          "stage 0 breast cancer aJCC v6",
          "stage 0 breast cancer aJCC v6 and v7",
          "stage 0 breast cancer aJCC v7",
          "stage 0 breast carcinoma",
          "stage 0 breast carcinoma in situ",
          "stage 0 carcinoma of breast",
          "stage 0 carcinoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the breast."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004658"
    },
    {
      "id": 6729,
      "label": "breast adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6712,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3458",
          "EFO:0000304",
          "MEDGEN:167809",
          "NCIT:C5214",
          "UMLS:C0858252"
        ],
        "synonyms": [
          "adenocarcinoma of breast",
          "adenocarcinoma of the breast",
          "breast adenocarcinoma",
          "mammary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the breast"
      },
      "child_count": 39,
      "reference_id": "MONDO:0004988"
    },
    {
      "id": 7267,
      "label": "male breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1614",
          "EFO:0006861",
          "GARD:0009312",
          "ICD9:175.9",
          "MEDGEN:68650",
          "MESH:D018567",
          "NCIT:C3862",
          "SCTID:372095001",
          "UMLS:C0238033"
        ],
        "synonyms": [
          "Male breast cancer",
          "Male breast carcinoma",
          "carcinoma of Male breast",
          "carcinoma of male breast",
          "carcinoma of the Male breast",
          "male breast cancer",
          "male breast carcinoma",
          "breast cancer in men",
          "breast cancer, male"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the male breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005628"
    },
    {
      "id": 7684,
      "label": "breast carcinoma by gene expression profile",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000143",
          "MEDGEN:770984",
          "NCIT:C53553",
          "UMLS:C3642344"
        ],
        "synonyms": [
          "breast carcinoma by gene expression profile"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A header term that includes the following breast carcinoma subtypes determined by gene expression profiling: luminal A breast carcinoma, luminal B breast carcinoma, HER2 positive breast carcinoma, basal-like breast carcinoma, triple-negative breast carcinoma, and normal breast-like subtype of breast carcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006116"
    },
    {
      "id": 7803,
      "label": "invasive breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000307",
          "MEDGEN:163435",
          "NCIT:C9245",
          "ONCOTREE:BRCA",
          "SCTID:713609000",
          "UMLS:C0853879",
          "icd11.foundation:2090549892"
        ],
        "synonyms": [
          "infiltrating breast cancer",
          "infiltrating breast carcinoma",
          "infiltrating carcinoma of breast",
          "infiltrating carcinoma of the breast",
          "invasive breast cancer",
          "invasive breast carcinoma",
          "invasive carcinoma of breast",
          "invasive carcinoma of the breast",
          "invasive mammary carcinoma",
          "BRCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women."
      },
      "child_count": 22,
      "reference_id": "MONDO:0006256"
    },
    {
      "id": 8196,
      "label": "Ehrlich tumor carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5050",
          "EFO:1000913",
          "MEDGEN:40103",
          "MESH:D002286",
          "UMLS:C0007125"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006739"
    },
    {
      "id": 16935,
      "label": "hereditary breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017142",
          "MEDGEN:87542",
          "MESH:C562840",
          "NCIT:C4503",
          "OMIM:114480",
          "Orphanet:227535",
          "SCTID:254843006",
          "UMLS:C0346153"
        ],
        "synonyms": [
          "breast cancer susceptibility, autosomal dominant, somatic mutation",
          "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
          "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
          "breast cancer, lobular, somatic",
          "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
          "breast cancer, protection against, autosomal dominant, somatic mutation",
          "breast cancer, somatic",
          "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
          "familial breast cancer",
          "familial breast carcinoma",
          "familial cancer of breast",
          "familial cancer of the breast",
          "hereditary breast cancer",
          "hereditary breast carcinoma",
          "breast cancer, familial",
          "breast cancer, familial Male"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016419"
    },
    {
      "id": 23545,
      "label": "cribriform carcinoma of breast",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730,
        7734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5675",
          "MEDGEN:1843502",
          "UMLS:C2138440",
          "icd11.foundation:1025219649"
        ],
        "synonyms": [
          "cribriform carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0045059"
    },
    {
      "id": 23668,
      "label": "hormone-resistant breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1631521",
          "NCIT:C114932",
          "UMLS:C4049259"
        ],
        "synonyms": [
          "hormone-refractory breast cancer",
          "hormone-resistant breast cancer",
          "hormone-resistant breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Breast carcinoma that does not respond to hormone therapy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0056813"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 8659,
      "label": "breast cancer"
    }
  ]
}