{
  "id": 6731,
  "label": "breast tumor luminal A or B",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004990",
  "properties": {
    "xrefs": [
      "DOID:0060548",
      "EFO:0000306"
    ],
    "synonyms": [
      "breast tumor luminal",
      "breast tumour luminal",
      "luminal breast cancer",
      "luminal breast carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "Subsets of breast carcinoma defined by expression of genes characteristic of luminal epithelial cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7684,
      "label": "breast carcinoma by gene expression profile",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000143",
          "MEDGEN:770984",
          "NCIT:C53553",
          "UMLS:C3642344"
        ],
        "synonyms": [
          "breast carcinoma by gene expression profile"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A header term that includes the following breast carcinoma subtypes determined by gene expression profiling: luminal A breast carcinoma, luminal B breast carcinoma, HER2 positive breast carcinoma, basal-like breast carcinoma, triple-negative breast carcinoma, and normal breast-like subtype of breast carcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006116"
    }
  ],
  "children": [
    {
      "id": 20354,
      "label": "luminal B breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6731
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080674",
          "MEDGEN:770986",
          "NCIT:C53555",
          "UMLS:C3642346"
        ],
        "synonyms": [
          "Luminal B",
          "Luminal B breast cancer",
          "Luminal B breast carcinoma",
          "Luminal B estrogen receptor positive subtype of breast carcinoma",
          "Luminal B oestrogen receptor positive subtype of breast carcinoma",
          "Luminal B subtype of breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A biologic subset of breast carcinoma defined by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1. This subtype of breast cancer is associated with a good prognosis, although not as favorable as the luminal A subtype."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021115"
    },
    {
      "id": 20355,
      "label": "luminal A breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6731
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:770985",
          "NCIT:C53554",
          "UMLS:C3642345"
        ],
        "synonyms": [
          "Luminal A",
          "Luminal A breast cancer",
          "Luminal A breast carcinoma",
          "Luminal A estrogen receptor positive subtype of breast carcinoma",
          "Luminal A oestrogen receptor positive subtype of breast carcinoma",
          "Luminal A subtype of breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A biologic subset of breast carcinoma defined by high expression of genes characteristic of luminal epithelial cells, including estrogen receptor (ER), estrogen regulated protein LIV-1, and the transcription factors hepatocyte nuclear factor 3, HNF3A, XBP1, and GATA 3. This subtype of breast cancer is associated with a good prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021116"
    }
  ],
  "roots": [
    {
      "id": 7684,
      "label": "breast carcinoma by gene expression profile"
    }
  ]
}