{ "id": 6733, "label": "cancer", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0004992", "properties": { "xrefs": [ "DOID:0050686", "DOID:0050687", "DOID:162", "ICD9:195.8", "ICD9:199", "ICD9:199.1", "ICDO:8000/3", "MEDGEN:14297", "NCIT:C9305", "ONCOTREE:MT", "SCTID:363346000", "UMLS:C0006826", "birnlex:406" ], "synonyms": [ "CA", "cancer", "cell type cancer", "malignancy", "malignant growth", "malignant neoplasm", "malignant neoplasm (disease)", "malignant neoplastic disease", "malignant tumor", "malignant tumour", "neoplasm (disease), malignant", "neoplasm, malignant", "MT" ], "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas." }, "isLeaf": false, "isRoot": false, "child_count": 33, "parents": [ { "id": 6798, "label": "neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 21214 ], "type_id": 0, "properties": { "xrefs": [ "DOID:14566", "EFO:0000616", "HP:0002664", "ICD10CM:C00-D49", "ICD10CM:C7A-C7A", "ICD10CM:C7B-C7B", "ICD9:140-239", "ICD9:239.8", "ICD9:239.9", "MEDGEN:10294", "MESH:D009369", "NCIT:C3262", "ONCOTREE:OTHER", "SCTID:55342001", "UMLS:C0027651" ], "synonyms": [ "cell process disease", "disease of cellular proliferation", "neoplasia", "neoplasm", "neoplasm (disease)", "neoplastic disease", "neoplastic growth", "tumor", "tumor disease", "tumour", "tumour disease", "other neoplasm" ], "definition": "A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias." }, "child_count": 48, "reference_id": "MONDO:0005070" } ], "children": [ { "id": 2875, "label": "respiratory system cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 6815 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050615", "ICD10CM:C34", "ICD9:165.8", "ICD9:165.9", "MEDGEN:756863", "NCIT:C4571", "SCTID:449096009", "UMLS:C3164456", "icd11.foundation:401100796" ], "synonyms": [ "cancer of respiratory system", "malignant neoplasm of respiratory system", "malignant respiratory system neoplasm", "respiratory system cancer" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A malignant neoplasm involving the respiratory system" }, "child_count": 18, "reference_id": "MONDO:0000376" }, { "id": 3028, "label": "immune system cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 6778 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060083" ], "synonyms": [ "cancer of immune system", "immune system cancer", "malignant immune system neoplasm", "malignant neoplasm of immune system" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "A malignant neoplasm involving the immune system" }, "child_count": 50, "reference_id": "MONDO:0000621" }, { "id": 3041, "label": "musculoskeletal system cancer", "isLeaf": false, "isRoot": false, "parents": [ 4222, 6733 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060100", "MEDGEN:1714562", "NCIT:C166357", "UMLS:C0036210" ], "synonyms": [ "cancer of musculoskeletal system", "malignant musculoskeletal system neoplasm", "malignant neoplasm of musculoskeletal system", "musculoskeletal system cancer", "skeletal system cancer" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" } ], "definition": "A malignant neoplasm involving the musculoskeletal system" }, "child_count": 22, "reference_id": "MONDO:0000637" }, { "id": 3053, "label": "integumentary system cancer", "isLeaf": false, "isRoot": false, "parents": [ 4198, 6733 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060122" ], "synonyms": [ "cancer of integumental system", "integumental system cancer", "malignant integumental system neoplasm", "malignant neoplasm of integumental system" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A malignant neoplasm involving the integumental system" }, "child_count": 14, "reference_id": "MONDO:0000653" }, { "id": 4227, "label": "peritoneum cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 8339 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1725", "ICD9:158.8", "ICD9:158.9", "ICD9:159.8", "MEDGEN:102270", "NCIT:C3538", "SCTID:363492001", "UMLS:C0153467", "icd11.foundation:315445782" ], "synonyms": [ "cancer of peritoneum", "cancer of the peritoneum", "malignant neoplasm of peritoneum", "malignant peritoneal neoplasm", "malignant peritoneum neoplasm", "peritoneal cancer", "peritoneal cavity cancer", "peritoneum cancer" ], "definition": "A malignant neoplasm involving the peritoneum" }, "child_count": 12, "reference_id": "MONDO:0002087" }, { "id": 4237, "label": "cardiovascular cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 21585 ], "type_id": 0, "properties": { "xrefs": [ "DOID:176", "MEDGEN:858066", "NCIT:C114940", "UMLS:C3898472" ], "synonyms": [ "cardiovascular neoplasm", "cancer of cardiovascular system", "cardiovascular system cancer", "cardiovascular tumours", "malignant cardiovascular neoplasm", "malignant cardiovascular system neoplasm", "malignant neoplasm of cardiovascular system" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the cardiovascular system." }, "child_count": 4, "reference_id": "MONDO:0002100" }, { "id": 4279, "label": "reproductive system cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7638 ], "type_id": 0, "properties": { "xrefs": [ "DOID:193", "MEDGEN:233668", "NCIT:C36076", "UMLS:C1334618" ], "synonyms": [ "reproductive tumor", "reproductive tumour", "cancer of reproductive organ", "cancer of reproductive system", "malignant neoplasm of reproductive organ", "malignant neoplasm of reproductive system", "malignant reproductive organ neoplasm", "malignant reproductive system neoplasm", "reproductive organ cancer", "reproductive system cancer" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A malignant neoplasm involving the reproductive organ" }, "child_count": 16, "reference_id": "MONDO:0002149" }, { "id": 4492, "label": "malignant giant cell tumor", "isLeaf": false, "isRoot": false, "parents": [ 4297, 6733 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2705", "ICDO:8003/3", "MEDGEN:90745", "NCIT:C4090", "UMLS:C0334229" ], "synonyms": [ "giant cell tumor, malignant", "malignant giant cell neoplasm", "malignant giant cell tumor", "malignant tumor, giant cell type", "malignant tumor, giant cell type (morphologic abnormality)" ], "definition": "A malignant neoplasm characterized by then presence of atypical giant cells." }, "child_count": 8, "reference_id": "MONDO:0002402" }, { "id": 4587, "label": "digestive system cancer", "isLeaf": false, "isRoot": false, "parents": [ 6151, 6733, 20434 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3119", "ICD10CM:C15-C26", "ICD9:239.0", "MEDGEN:148231", "NCIT:C4890", "UMLS:C0751075" ], "synonyms": [ "GI tumor", "GI tumour", "cancer of digestive system", "digestive system cancer", "gastrointestinal system cancer", "malignant digestive system neoplasm", "malignant gastrointestinal neoplasm", "malignant gastrointestinal system neoplasm", "malignant neoplasm of digestive system" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving any part of the digestive system." }, "child_count": 45, "reference_id": "MONDO:0002516" }, { "id": 4839, "label": "lipomatous cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 20521 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3939", "ICD9:171.9", "NCIT:C4501", "SCTID:254828009" ], "synonyms": [ "adipose tissue cancer", "cancer of adipose tissue", "malignant adipose tissue neoplasm", "malignant adipose tissue tumor", "malignant adipose tissue tumour", "malignant lipomatous neoplasm", "malignant lipomatous tumor", "malignant lipomatous tumour", "malignant neoplasm of adipose tissue", "malignant neoplasm of the adipose tissue", "malignant tumor of adipose tissue", "malignant tumor of the adipose tissue", "malignant tumour of adipose tissue", "malignant tumour of the adipose tissue" ], "categories": [ { "ref": "MONDO:0003900", "name": "connective tissue disorder" } ], "definition": "A malignant mesenchymal neoplasm arising from adipocytes." }, "child_count": 2, "reference_id": "MONDO:0002813" }, { "id": 5215, "label": "thoracic cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 20518 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5093", "ICD10CM:C76.1", "ICD9:195.1", "MEDGEN:56320", "NCIT:C3576", "SCTID:188361007", "UMLS:C0153661" ], "synonyms": [ "thoracic tumor", "thoracic tumour", "thorax neoplasm", "tumor of thorax", "tumour of thorax", "cancer of thoracic segment of trunk", "malignant neoplasm of the thorax", "malignant neoplasm of thoracic segment of trunk", "malignant neoplasm of thorax", "malignant thoracic neoplasm", "malignant thoracic segment of trunk neoplasm", "malignant thoracic tumor", "malignant thoracic tumour", "malignant tumor of the thorax", "malignant tumor of thorax", "malignant tumour of the thorax", "malignant tumour of thorax", "thoracic segment of trunk cancer" ], "definition": "A primary or metastatic malignant neoplasm affecting the tissues of the thorax." }, "child_count": 16, "reference_id": "MONDO:0003274" }, { "id": 5276, "label": "malignant glomus tumor", "isLeaf": true, "isRoot": false, "parents": [ 6733, 18422 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5233", "GARD:0023459", "ICDO:8710/3", "ICDO:8711/3", "MEDGEN:226840", "NCIT:C4221", "ONCOTREE:MGST", "UMLS:C1266111" ], "synonyms": [ "glomangiosarcoma", "glomus tumor, malignant", "malignant glomus neoplasm", "malignant glomus tumor" ], "definition": "A very rare morphologic variant of glomus tumor with a size greater than 2 cm. The tumor arises in subfascial or visceral tissues. It is characterized by the presence of atypical mitotic figures, or marked nuclear atypia, or the combination of both. It has an aggressive clinical course." }, "child_count": 0, "reference_id": "MONDO:0003340" }, { "id": 5522, "label": "malignant mesenchymoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 8297 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5758", "ICDO:8990/3", "MEDGEN:87252", "NCIT:C4268", "UMLS:C0334492" ], "synonyms": [ "mesenchymoma, malignant", "mesenchymoma, malignant (morphologic abnormality)" ], "definition": "A term describing a malignant soft tissue tumor which consists of two or more mesenchymal lines of differentiation, excluding a fibroblastic line of differentiation." }, "child_count": 4, "reference_id": "MONDO:0003633" }, { "id": 6734, "label": "carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7265 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-1867", "DOID:305", "EFO:0000313", "ICDO:8010/3", "ICDO:8011/3", "MEDGEN:2867", "MESH:D002277", "NCIT:C2916", "SCTID:722688002", "UMLS:C0007097" ], "synonyms": [ "epithelioma", "Other carcinoma", "carcinoma", "carcinoma, malignant", "epithelial carcinoma", "epithelioma malignant", "malignant epithelial neoplasm", "malignant epithelial tumor", "malignant epithelial tumour", "malignant epithelioma" ], "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." }, "child_count": 98, "reference_id": "MONDO:0004993" }, { "id": 6816, "label": "sarcoma", "isLeaf": false, "isRoot": false, "parents": [ 6733 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1115", "EFO:0000691", "ICD9:171", "ICD9:171.0", "ICD9:171.2", "ICD9:171.3", "ICD9:171.4", "ICD9:171.5", "ICD9:171.6", "ICD9:171.7", "ICD9:171.8", "ICD9:171.9", "ICDO:8800/3", "MEDGEN:224714", "MESH:D012509", "NCIT:C9118", "SCTID:424413001", "UMLS:C1261473" ], "synonyms": [ "mesenchymal tumor, malignant", "sarcoma", "sarcoma of soft tissue and bone", "sarcoma of the soft tissue and bone", "sarcoma, malignant", "tumor of soft tissue and skeleton", "tumour of soft tissue and skeleton" ], "definition": "A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma." }, "child_count": 22, "reference_id": "MONDO:0005089" }, { "id": 7213, "label": "blastoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7212 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0070003", "DOID:4766", "EFO:0005785", "ICDO:8981/3", "MEDGEN:181704", "NCIT:C8997", "UMLS:C0936282" ], "synonyms": [ "blastoma", "embryoma" ], "definition": "A malignant neoplasm composed of undifferentiated cells." }, "child_count": 6, "reference_id": "MONDO:0005565" }, { "id": 7266, "label": "head and neck cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7231 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11934", "EFO:0006859", "MEDGEN:78920", "NCIT:C4013", "UMLS:C0278996" ], "synonyms": [ "head and neck neoplasm", "head and neck tumors", "head and neck tumours", "head/neck neoplasm", "tumour of head and neck", "cancer of craniocervical region", "cancer of head and neck", "cancer of the head and neck", "craniocervical region cancer", "head and neck cancer", "head and neck malignant neoplasia", "malignant craniocervical region neoplasm", "malignant head and neck neoplasm", "malignant head and neck tumor", "malignant head and neck tumour", "malignant neoplasm of craniocervical region", "malignant neoplasm of head and neck", "malignant neoplasm of the head and neck", "malignant tumor of head and neck", "malignant tumor of the head and neck", "malignant tumour of head and neck", "malignant tumour of the head and neck" ], "definition": "A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma." }, "child_count": 32, "reference_id": "MONDO:0005627" }, { "id": 7464, "label": "malignant mixed neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733, 20288 ], "type_id": 0, "properties": { "xrefs": [ "DOID:154", "EFO:1000356", "ICDO:8940/3", "MEDGEN:64618", "MESH:D018198", "NCIT:C3729", "UMLS:C0206625" ], "synonyms": [ "mixed cell type cancer", "mixed neoplasm", "mixed tumor", "mixed tumour", "malignant mixed neoplasm", "malignant mixed tumor", "malignant mixed tumour", "mixed neoplasm, malignant", "mixed tumor, malignant (morphologic abnormality)", "mixed tumor, malignant, NOS (morphologic abnormality)", "tumor, mixed, malignant", "malignant mixed tumors", "malignant mixed tumours", "mixed tumors, malignant", "tumor, malignant mixed", "tumors, malignant mixed" ], "definition": "A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung." }, "child_count": 30, "reference_id": "MONDO:0005853" }, { "id": 7479, "label": "nervous system cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 20456 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3093", "EFO:0007392", "ICD9:192", "ICD9:192.8", "ICD9:192.9", "MEDGEN:99231", "MESH:D009423", "NCIT:C4788", "SCTID:372063002", "UMLS:C0497549" ], "synonyms": [ "nervous system neoplasm", "neural neoplasm", "neural tumor", "neural tumour", "tumor of the nervous system", "tumour of the nervous system", "cancer of nervous system", "malignant neoplasm of nervous system", "malignant neoplasm of the nervous system", "malignant nervous system neoplasm", "malignant nervous system tumor", "malignant nervous system tumour", "malignant tumor of nervous system", "malignant tumor of the nervous system", "malignant tumour of nervous system", "malignant tumour of the nervous system", "nervous system cancer", "nervous system neoplasms, malignant" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the nervous system." }, "child_count": 12, "reference_id": "MONDO:0005872" }, { "id": 7537, "label": "retroperitoneal cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733, 21554 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5875", "EFO:0007466", "ICD9:158", "ICD9:158.0", "MEDGEN:57559", "MESH:D012186", "NCIT:C3537", "SCTID:126872008", "UMLS:C0153465", "icd11.foundation:1731312506" ], "synonyms": [ "neoplasm of retroperitoneum", "neoplasm of the retroperitoneum", "retroperitoneal neoplasm", "tumor of retroperitoneum", "tumour of retroperitoneum", "cancer of retroperitoneal space", "malignant neoplasm of retroperitoneal space", "malignant neoplasm of retroperitoneum and peritoneum", "malignant retroperitoneal neoplasm", "malignant retroperitoneal space neoplasm", "malignant tumour of peritoneum and retroperitoneum", "retroperitoneal space cancer", "malignant neoplasm of retroperitoneum" ], "definition": "A primary or metastatic malignant neoplasm involving the retroperitoneum. The vast majority of cases are carcinomas, lymphomas, or sarcomas." }, "child_count": 8, "reference_id": "MONDO:0005941" }, { "id": 7832, "label": "malignant germ cell tumor", "isLeaf": false, "isRoot": false, "parents": [ 6733, 6773 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000352", "GARD:0003360", "MEDGEN:890580", "NCIT:C4925", "SCTID:145831000119103", "UMLS:C4048549" ], "synonyms": [ "cancer of germ cell", "germ cell cancer", "germ cell tumor, malignant", "malignant germ cell neoplasm", "malignant germ cell tumor", "malignant neoplasm of germ cell", "malignant neoplasm of the germ cell", "malignant tumor of germ cell", "malignant tumor of the germ cell", "malignant tumour of germ cell", "malignant tumour of the germ cell" ], "definition": "A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma." }, "child_count": 26, "reference_id": "MONDO:0006290" }, { "id": 7834, "label": "malignant mesothelioma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 6794 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1790", "EFO:1000355", "GARD:0007026", "HP:0100001", "ICD9:199.1", "ICDO:9050/3", "MEDGEN:91062", "MESH:C562839", "MedDRA:10027406", "NCIT:C4456", "OMIM:156240", "Orphanet:50251", "SCTID:109378008", "UMLS:C0345967", "icd11.foundation:369414280" ], "synonyms": [ "malignant mesothelial tumor", "malignant mesothelial tumour", "malignant mesothelioma", "malignant mesothelioma (disease)", "malignant neoplasm of mesothelium", "malignant neoplasm of the mesothelium", "malignant tumor of mesothelium", "malignant tumor of the mesothelium", "malignant tumour of mesothelium", "malignant tumour of the mesothelium", "mesothelioma, malignant", "mesothelioma, somatic", "advanced malignant mesothelioma", "asbestos-related malignant mesothelioma", "diffuse malignant mesothelioma", "malignant mesothelial neoplasm", "MESOM" ], "definition": "A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells. It is associated with exposure to asbestos." }, "child_count": 22, "reference_id": "MONDO:0006292" }, { "id": 7836, "label": "malignant urinary system neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733, 20307 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3996", "EFO:1000363", "ICD10CM:C64-C68", "ICD9:189.9", "MEDGEN:738719", "NCIT:C192668", "NCIT:C9297", "SCTID:448233000", "UMLS:C1644719" ], "synonyms": [ "cancer of renal system", "malignant neoplasm of renal system", "malignant renal system neoplasm", "malignant urinary system neoplasm", "malignant urinary tract neoplasm", "renal system cancer", "urinary system cancer" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A primary or metastatic malignant tumor involving the urinary system. Common tumor types include carcinomas, lymphomas, and sarcomas." }, "child_count": 20, "reference_id": "MONDO:0006295" }, { "id": 8005, "label": "childhood malignant neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733, 20320 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000654", "MEDGEN:82962", "NCIT:C4005", "UMLS:C0278704" ], "synonyms": [ "childhood cancer", "childhood malignant neoplasm", "childhood neoplasm, malignant", "malignant childhood neoplasm", "malignant childhood tumor", "malignant childhood tumour", "malignant paediatric neoplasm", "malignant paediatric tumour", "malignant pediatric neoplasm", "malignant pediatric tumor", "paediatric cancer", "pediatric cancer", "malignant neoplasm" ], "definition": "A malignant tumor that occurs in children. Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor)." }, "child_count": 60, "reference_id": "MONDO:0006517" }, { "id": 20048, "label": "anaplastic cancer", "isLeaf": false, "isRoot": false, "parents": [ 6733 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:231373", "NCIT:C36025", "UMLS:C1332287" ], "synonyms": [ "anaplastic malignant neoplasm" ] }, "child_count": 8, "reference_id": "MONDO:0020633" }, { "id": 20076, "label": "malignant spindle cell neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733, 20077 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:90746", "NCIT:C27091", "UMLS:C0334230" ], "synonyms": [ "malignant spindle cell neoplasm", "malignant spindle cell tumor", "malignant spindle cell tumour", "spindle cell cancer" ], "definition": "A malignant neoplasm characterized by the presence of atypical spindle cells." }, "child_count": 8, "reference_id": "MONDO:0020663" }, { "id": 20078, "label": "high grade malignant neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:234350", "NCIT:C36046", "UMLS:C1334017" ], "synonyms": [ "high grade malignant neoplasm" ] }, "child_count": 3, "reference_id": "MONDO:0020665" }, { "id": 20310, "label": "malignant endocrine neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4223, 6733 ], "type_id": 0, "properties": { "xrefs": [ "DOID:170", "ICD9:194.9", "MEDGEN:56319", "MESH:D004701", "NCIT:C3575", "UMLS:C0153658" ], "synonyms": [ "endocrine neoplasm", "Endocrine tumour", "cancer of endocrine gland", "endocrine cancer", "endocrine gland cancer", "endocrine neoplasm, malignant", "malignant endocrine gland neoplasm", "malignant endocrine gland tumor", "malignant endocrine gland tumour", "malignant endocrine neoplasm", "malignant endocrine tumor", "malignant endocrine tumour", "malignant neoplasm of endocrine gland", "malignant neoplasm of the endocrine gland", "malignant tumor of endocrine gland", "malignant tumor of the endocrine gland", "malignant tumour of the endocrine gland" ], "categories": [ { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma." }, "child_count": 32, "reference_id": "MONDO:0021069" }, { "id": 21548, "label": "malignant soft tissue neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7941 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0027918", "MEDGEN:1632429", "NCIT:C4867", "SCTID:269469005", "UMLS:C4551686" ], "synonyms": [ "malignant neoplasm of soft tissue", "malignant neoplasm of the soft tissue", "malignant soft tissue neoplasm", "malignant soft tissue tumor", "malignant soft tissue tumour", "malignant tumor of soft tissue", "malignant tumor of the soft tissue", "malignant tumour of soft tissue", "malignant tumour of the soft tissue" ], "definition": "A malignant neoplasm arising exclusively from the soft tissues." }, "child_count": 6, "reference_id": "MONDO:0024637" }, { "id": 21605, "label": "secondary malignant neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733, 21606 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0009812", "ICD9:198.89", "ICD9:199.1", "MEDGEN:473807", "NCIT:C4968", "SCTID:128462008", "UMLS:C3266877" ], "synonyms": [ "secondary cancer", "secondary malignancy", "secondary malignant neoplasm" ], "definition": "A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment." }, "child_count": 4, "reference_id": "MONDO:0024881" }, { "id": 22941, "label": "refractory malignant neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6733 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:146772", "NCIT:C120186", "UMLS:C0677936" ], "synonyms": [ "refractory cancer", "refractory malignant neoplasm", "resistant cancer", "clinical resistance" ], "definition": "A malignant neoplasm that does not respond to treatment." }, "child_count": 1, "reference_id": "MONDO:0036501" }, { "id": 25153, "label": "malignant adenoma", "isLeaf": false, "isRoot": false, "parents": [ 6733 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080364" ], "definition": "A cell type cancer that is composed of epithelial tissue in which tumor cells form glands or glandlike structures, representing an early form of colorectal cancer." }, "child_count": 1, "reference_id": "MONDO:0850125" }, { "id": 25265, "label": "cancer of unknown primary site", "isLeaf": true, "isRoot": false, "parents": [ 6733 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0026640", "MEDGEN:10298", "NCIT:C8566", "Orphanet:631251", "UMLS:C0027667" ] }, "child_count": 0, "reference_id": "MONDO:0858997" } ], "roots": [ { "id": 6798, "label": "neoplasm" } ] }