{
  "id": 6740,
  "label": "chronic obstructive pulmonary disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005002",
  "properties": {
    "xrefs": [
      "DOID:3083",
      "EFO:0000341",
      "ICD9:490-496",
      "ICD9:496",
      "MEDGEN:9818",
      "MESH:D029424",
      "NCIT:C3199",
      "OMIM:606963",
      "SCTID:13645005",
      "UMLS:C0024117",
      "icd11.foundation:133207228"
    ],
    "synonyms": [
      "COLD",
      "COPD",
      "COPD, chronic obstructive pulmonary disease",
      "chronic obstructive airways disease",
      "chronic obstructive lung disease",
      "chronic obstructive pulmonary disease (COPD)",
      "chronic obstructive pulmonary disease, (COPD)",
      "cold",
      "cold (chronic obstructive lung disease)",
      "disease (COPD), chronic obstructive",
      "obstructive lung disease, chronic",
      "obstructive pulmonary disease (COPD), chronic",
      "pulmonary disease (COPD), chronic obstructive"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4382,
      "label": "obstructive lung disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6971
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2320",
          "MEDGEN:1387",
          "MESH:D008173",
          "UMLS:C0001883"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Any disorder marked by obstruction of conducting airways of the lung. airway obstruction may be acute, chronic, intermittent, or persistent."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002267"
    },
    {
      "id": 4630,
      "label": "tracheal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2809,
        6623
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3225",
          "MEDGEN:892789",
          "MESH:D014133",
          "NCIT:C35079",
          "SCTID:47125007",
          "UMLS:C4025678"
        ],
        "synonyms": [
          "disease of trachea",
          "disease or disorder of trachea",
          "disorder of trachea",
          "trachea disease",
          "trachea disease or disorder",
          "tracheal disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the trachea. Representative examples of non-neoplastic disorders include congenital malformations and infection. Representative examples of neoplastic disorders include carcinoma and lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002567"
    }
  ],
  "children": [
    {
      "id": 6582,
      "label": "bronchiectasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3582,
        5714,
        6740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9563",
          "ICD10CM:J47",
          "ICD10WHO:J47",
          "ICD9:494",
          "MEDGEN:14234",
          "MESH:D001987",
          "NANDO:2100036",
          "NANDO:2200206",
          "NCIT:C84475",
          "OMIMPS:211400",
          "SCTID:12295008",
          "UMLS:C0006267",
          "icd11.foundation:1935524933"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Segmental, irreversible dilation of the bronchial tree resulting in the accumulation of secretions which leads to obstruction. The most common cause is bacterial infection."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004822"
    },
    {
      "id": 6606,
      "label": "pulmonary emphysema",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9675",
          "EFO:0000464",
          "ICD10CM:J43",
          "ICD9:492",
          "ICD9:492.8",
          "MEDGEN:18764",
          "MESH:D004646",
          "MESH:D011656",
          "NCIT:C3348",
          "SCTID:87433001",
          "UMLS:C0034067"
        ],
        "synonyms": [
          "emphysema",
          "emphysema, pulmonary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A subcategory of chronic obstructive pulmonary disease (COPD). It occurs in people who smoke and suffer from chronic bronchitis. It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing."
      },
      "child_count": 5,
      "reference_id": "MONDO:0004849"
    },
    {
      "id": 7248,
      "label": "chronic bronchitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5660,
        6740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006505",
          "ICD9:491",
          "ICD9:491.8",
          "ICD9:491.9",
          "MEDGEN:3084",
          "MESH:D029481",
          "NCIT:C26722",
          "SCTID:63480004",
          "UMLS:C0008677",
          "icd11.foundation:290835130"
        ],
        "synonyms": [
          "bronchitis, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A type of chronic obstructive pulmonary disease characterized by chronic inflammation in the bronchial tree that results in edema, mucus production, obstruction, and reduced airflow to and from the lung alveoli. The most common cause is tobacco smoking. Signs and symptoms include coughing with excessive mucus production, and shortness of breath."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005607"
    },
    {
      "id": 12592,
      "label": "diffuse panbronchiolitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008526",
          "ICD9:491.8",
          "MEDGEN:163897",
          "MESH:C536174",
          "MedDRA:10062952",
          "OMIM:604809",
          "Orphanet:171700",
          "SCTID:430476004",
          "UMLS:C0878555",
          "icd11.foundation:291357751"
        ],
        "synonyms": [
          "DPb",
          "PBLT",
          "panbronchiolitis, diffuse"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Diffuse panbronchiolitis is a rare chronic inflammatory obstructive pulmonary disease primarily affecting the respiratory bronchioles throughout both lungs and inducing sinobronchial infection. Onset occurs in the second to fifth decade of life and manifests by chronic cough, exertional dyspnea, and sputum production. Most patients also have chronic paranasal sinusitis"
      },
      "child_count": 0,
      "reference_id": "MONDO:0011490"
    },
    {
      "id": 12837,
      "label": "COPD, severe early onset",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:376022",
          "UMLS:C1847014"
        ],
        "synonyms": [
          "COPD",
          "pulmonary disease, chronic obstructive",
          "COPD, rate of decline of lung function in",
          "COPD, severe early-onset",
          "pulmonary disease, chronic obstructive, severe early-onset"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011751"
    }
  ],
  "roots": [
    {
      "id": 4382,
      "label": "obstructive lung disease"
    },
    {
      "id": 4630,
      "label": "tracheal disorder"
    }
  ]
}