{
  "id": 6742,
  "label": "clear cell adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005004",
  "properties": {
    "xrefs": [
      "DOID:4468",
      "EFO:0000348",
      "ICDO:8310/3",
      "MEDGEN:64629",
      "MESH:D018262",
      "NCIT:C3766",
      "UMLS:C0206681"
    ],
    "synonyms": [
      "adenocarcinoma, clear cell, malignant",
      "clear cell adenocarcinoma",
      "clear cell adenocarcinoma (morphologic abnormality)",
      "clear cell adenocarcinoma NOS (morphologic abnormality)",
      "mesonephroma NOS (morphologic abnormality)",
      "water-clear cell adenocarcinoma (morphologic abnormality)",
      "Wolffian duct neoplasm",
      "clear cell carcinoma",
      "malignant mesonephroma",
      "mesonephroid clear cell adenocarcinoma",
      "mesonephroid clear cell carcinoma",
      "mesonephroma, malignant",
      "mesonephroma, malignant (morphologic abnormality)",
      "water-clear cell carcinoma"
    ],
    "definition": "A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    }
  ],
  "children": [
    {
      "id": 5189,
      "label": "hepatocellular clear cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6742,
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5016",
          "GARD:0023418",
          "ICDO:8174/3",
          "MEDGEN:690059",
          "NCIT:C5754",
          "UMLS:C1266020"
        ],
        "synonyms": [
          "clear cell carcinoma of liver cells",
          "clear cell carcinoma of the liver cells",
          "clear cell hepatocellular cancer",
          "clear cell hepatocellular carcinoma",
          "hepatocellular clear cell carcinoma",
          "liver cell clear cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of hepatocellular carcinoma characterized by the presence of clear cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003243"
    },
    {
      "id": 5316,
      "label": "fallopian tube clear cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4781,
        6742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5301",
          "GARD:0023492",
          "MEDGEN:232184",
          "NCIT:C6280",
          "UMLS:C1333591"
        ],
        "synonyms": [
          "clear cell adenocarcinoma of fallopian tube",
          "clear cell adenocarcinoma of the fallopian tube",
          "clear cell carcinoma of fallopian tube",
          "clear cell carcinoma of the fallopian tube",
          "fallopian tube clear cell adenocarcinoma",
          "fallopian tube clear cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare adenocarcinoma of the fallopian tube composed of malignant glandular epithelium containing clear cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003383"
    },
    {
      "id": 5318,
      "label": "bladder clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4786,
        6742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5306",
          "MEDGEN:272370",
          "NCIT:C6179",
          "UMLS:C1332557"
        ],
        "synonyms": [
          "bladder clear cell adenocarcinoma",
          "urinary bladder clear cell adenocarcinoma",
          "clear cell adenocarcinoma of the bladder",
          "clear cell adenocarcinoma of the urinary bladder",
          "clear cell adenocarcinoma of urinary bladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells distributed in a tubulo-cystic, papillary, or diffuse pattern. There is a female predilection. Clinical presentation includes hematuria and dysuria."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003386"
    },
    {
      "id": 5319,
      "label": "urethra clear cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5159,
        6742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5307",
          "GARD:0027638",
          "MEDGEN:277846",
          "NCIT:C6172",
          "UMLS:C1336886"
        ],
        "synonyms": [
          "clear cell adenocarcinoma of the urethra",
          "clear cell adenocarcinoma of urethra",
          "urethra clear cell adenocarcinoma",
          "urethral clear cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A morphologic variant of urethral adenocarcinoma characterized by the presence of tubulocystic or papillary structures lined with clear cuboidal or hobnail cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003387"
    },
    {
      "id": 5322,
      "label": "glycogen-rich clear cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698,
        6742,
        23541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5310",
          "ICDO:8315/3",
          "MEDGEN:1785052",
          "NCIT:C40368",
          "UMLS:C2012261"
        ],
        "synonyms": [
          "glycogen-rich carcinoma",
          "glycogen-rich carcinoma (morphologic abnormality)",
          "glycogen-rich, clear cell breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An uncommon, usually aggressive adenocarcinoma of the breast characterized by the presence of clear cells that contain glycogen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003390"
    },
    {
      "id": 5917,
      "label": "extrahepatic bile duct clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        6742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7032",
          "GARD:0023808",
          "MEDGEN:167829",
          "NCIT:C5775",
          "UMLS:C0861855"
        ],
        "synonyms": [
          "bile duct clear cell adenocarcinoma",
          "clear cell adenocarcinoma of bile duct",
          "clear cell adenocarcinoma of the bile duct",
          "clear cell bile duct adenocarcinoma",
          "extrahepatic bile duct clear cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of extrahepatic bile duct adenocarcinoma characterized by the presence of malignant glandular epithelium composed of clear cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004081"
    },
    {
      "id": 6743,
      "label": "clear cell renal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6742,
        7199,
        9112
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4467",
          "EFO:0000349",
          "GARD:0009574",
          "ICD9:189.0",
          "MEDGEN:76018",
          "NCIT:C4033",
          "ONCOTREE:CCRCC",
          "Orphanet:319276",
          "SCTID:254915003",
          "UMLS:C0279702"
        ],
        "synonyms": [
          "Grawitz tumor",
          "Grawitz tumour",
          "RCC, clear cell adenocarcinoma",
          "clear cell adenocarcinoma of kidney",
          "clear cell adenocarcinoma of the kidney",
          "clear cell adenocarcinoma, kidney",
          "clear cell carcinoma of kidney",
          "clear cell carcinoma of the kidney",
          "clear cell renal cell cancer",
          "clear cell renal cell carcinoma",
          "conventional (clear cell) renal cell adenocarcinoma",
          "conventional (clear cell) renal cell carcinoma",
          "conventional renal cell carcinoma",
          "kidney clear cell adenocarcinoma",
          "kidney clear cell carcinoma",
          "renal cell carcinoma, clear cell adenocarcinoma",
          "renal clear cell adenocarcinoma",
          "renal clear cell carcinoma",
          "clear-cell metastatic renal cell carcinoma",
          "hypernephroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005005"
    },
    {
      "id": 7631,
      "label": "ovarian clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2987,
        4787,
        6742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5304",
          "EFO:1000042",
          "GARD:0021652",
          "MEDGEN:276659",
          "NCIT:C40078",
          "Orphanet:398971",
          "SCTID:763131005",
          "UMLS:C1518693",
          "icd11.foundation:315825558"
        ],
        "synonyms": [
          "clear cell adenocarcinoma of ovary",
          "ovarian clear cell adenocarcinoma",
          "ovary clear cell adenocarcinoma",
          "clear cell adenocarcinoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant glandular epithelial neoplasm characterized by the presence of clear and hobnail cells. It is highly associated with ovarian endometriosis, pelvic endometriosis and paraendocrine hypercalcemia."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006045"
    },
    {
      "id": 7699,
      "label": "cervical clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6742,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5303",
          "EFO:1000163",
          "GARD:0024304",
          "MEDGEN:234113",
          "NCIT:C6344",
          "ONCOTREE:CECC",
          "UMLS:C1332912"
        ],
        "synonyms": [
          "cervical clear cell adenocarcinoma",
          "cervical clear cell carcinoma",
          "cervix clear cell adenocarcinoma",
          "cervix clear cell carcinoma",
          "cervix uteri clear cell adenocarcinoma",
          "cervix uteri clear cell carcinoma",
          "clear cell adenocarcinoma of cervix",
          "clear cell adenocarcinoma of cervix uteri",
          "clear cell adenocarcinoma of the cervix",
          "clear cell adenocarcinoma of the cervix uteri",
          "clear cell adenocarcinoma of the uterine cervix",
          "clear cell adenocarcinoma of uterine cervix",
          "clear cell carcinoma of cervix",
          "clear cell carcinoma of cervix uteri",
          "clear cell carcinoma of the cervix",
          "clear cell carcinoma of the cervix uteri",
          "clear cell carcinoma of the uterine cervix",
          "clear cell carcinoma of uterine cervix",
          "uterine cervix clear cell adenocarcinoma",
          "uterine cervix clear cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare morphologic variant of cervical adenocarcinoma composed of clear and hobnail cells. It is associated with in utero exposure to diethylstilbestrol (DES)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006135"
    },
    {
      "id": 7747,
      "label": "endometrial clear cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6742,
        7120
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5299",
          "EFO:1000231",
          "MEDGEN:124655",
          "NCIT:C8028",
          "UMLS:C0279765",
          "icd11.foundation:388735319"
        ],
        "synonyms": [
          "clear cell carcinoma of endometrium",
          "clear cell carcinoma of the endometrium",
          "endometrial clear cell adenocarcinoma",
          "endometrium clear cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A clear cell adenocarcinoma that involves the endometrium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006191"
    },
    {
      "id": 7795,
      "label": "hidradenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6742,
        7178
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000295",
          "ICDO:8402/3",
          "MEDGEN:137746",
          "NCIT:C54664",
          "UMLS:C0334344"
        ],
        "synonyms": [
          "clear cell eccrine carcinoma",
          "hidradenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma with apocrine and less often eccrine differentiation, arising from the sweat glands. It usually presents as a solitary slow growing nodule in the dermis or subcutaneous tissues. It is characterized by a nodular growth pattern and it is often associated with necrotic changes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006245"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    }
  ]
}