{
  "id": 6743,
  "label": "clear cell renal carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005005",
  "properties": {
    "xrefs": [
      "DOID:4467",
      "EFO:0000349",
      "GARD:0009574",
      "ICD9:189.0",
      "MEDGEN:76018",
      "NCIT:C4033",
      "ONCOTREE:CCRCC",
      "Orphanet:319276",
      "SCTID:254915003",
      "UMLS:C0279702"
    ],
    "synonyms": [
      "Grawitz tumor",
      "Grawitz tumour",
      "RCC, clear cell adenocarcinoma",
      "clear cell adenocarcinoma of kidney",
      "clear cell adenocarcinoma of the kidney",
      "clear cell adenocarcinoma, kidney",
      "clear cell carcinoma of kidney",
      "clear cell carcinoma of the kidney",
      "clear cell renal cell cancer",
      "clear cell renal cell carcinoma",
      "conventional (clear cell) renal cell adenocarcinoma",
      "conventional (clear cell) renal cell carcinoma",
      "conventional renal cell carcinoma",
      "kidney clear cell adenocarcinoma",
      "kidney clear cell carcinoma",
      "renal cell carcinoma, clear cell adenocarcinoma",
      "renal clear cell adenocarcinoma",
      "renal clear cell carcinoma",
      "clear-cell metastatic renal cell carcinoma",
      "hypernephroma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6742,
      "label": "clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4468",
          "EFO:0000348",
          "ICDO:8310/3",
          "MEDGEN:64629",
          "MESH:D018262",
          "NCIT:C3766",
          "UMLS:C0206681"
        ],
        "synonyms": [
          "adenocarcinoma, clear cell, malignant",
          "clear cell adenocarcinoma",
          "clear cell adenocarcinoma (morphologic abnormality)",
          "clear cell adenocarcinoma NOS (morphologic abnormality)",
          "mesonephroma NOS (morphologic abnormality)",
          "water-clear cell adenocarcinoma (morphologic abnormality)",
          "Wolffian duct neoplasm",
          "clear cell carcinoma",
          "malignant mesonephroma",
          "mesonephroid clear cell adenocarcinoma",
          "mesonephroid clear cell carcinoma",
          "mesonephroma, malignant",
          "mesonephroma, malignant (morphologic abnormality)",
          "water-clear cell carcinoma"
        ],
        "definition": "A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid."
      },
      "child_count": 11,
      "reference_id": "MONDO:0005004"
    },
    {
      "id": 7199,
      "label": "renal cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005708",
          "GARD:0024205",
          "ICDO:8311/1",
          "ICDO:8312/3",
          "NANDO:2200045",
          "NCIT:C9385"
        ],
        "synonyms": [
          "renal cell carcinoma",
          "RCC",
          "adenocarcinoma of kidney",
          "adenocarcinoma of the kidney",
          "carcinoma, renal cell, malignant",
          "kidney adenocarcinoma",
          "renal cell adenocarcinoma",
          "renal cell cancer",
          "renal cell carcinoma, stage unspecified"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005549"
    },
    {
      "id": 9112,
      "label": "nonpapillary renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050387",
          "GARD:0024575",
          "OMIM:144700"
        ],
        "synonyms": [
          "renal cell carcinoma",
          "renal carcinoma, chromophobe, somatic",
          "renal cell carcinoma, clear cell",
          "renal cell carcinoma, clear cell, somatic",
          "renal cell carcinoma, somatic",
          "CCRCC",
          "clear cell renal cell adenocarcinoma",
          "clear cell renal cell carcinoma",
          "RCC",
          "adenocarcinoma of kidney",
          "hypernephroma",
          "nonpapillary renal carcinoma 1 locus",
          "renal cell carcinoma, nonpapillary"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0007763"
    }
  ],
  "children": [
    {
      "id": 5008,
      "label": "multilocular clear cell renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6743
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4463",
          "GARD:0021417",
          "ICD9:189.0",
          "ICDO:8316/3",
          "MEDGEN:87547",
          "NCIT:C4524",
          "Orphanet:319287",
          "SCTID:254916002",
          "UMLS:C0346249"
        ],
        "synonyms": [
          "MCRCC",
          "multilocular clear cell adenocarcinoma",
          "multilocular clear cell carcinoma",
          "multilocular clear cell renal cell adenocarcinoma",
          "multilocular clear cell renal cell carcinoma",
          "multilocular cystic clear cell renal cell neoplasm of low malignant potential",
          "multilocular cystic renal cell adenocarcinoma",
          "multilocular cystic renal cell cancer",
          "multilocular cystic renal cell carcinoma",
          "renal cystadenocarcinoma",
          "multilocular cystic renal neoplasm of low malignant potential"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare type of renal cell carcinoma. It is a well-circumscribed multicystic mass without solid areas. The inner lining of the cystic structures is composed of clear cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003010"
    },
    {
      "id": 18529,
      "label": "hereditary clear cell renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5006,
        6743
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7192",
          "GARD:0009571",
          "MEDGEN:234343",
          "NCIT:C36260",
          "Orphanet:422526",
          "SCTID:764961009",
          "UMLS:C1333985"
        ],
        "synonyms": [
          "Hereditary clear cell renal cell cancer",
          "hereditary clear cell renal carcinoma",
          "hereditary clear cell renal cell adenocarcinoma",
          "hereditary clear cell renal cell carcinoma",
          "hereditary conventional (clear cell) renal cell carcinoma",
          "hereditary conventional renal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A manifestation of von Hippel-Lindau disease or other familial renal cell cancer syndromes that present as a malignant epithelial neoplasm of the kidney. It is characterized by the presence of lipid-containing clear cells within a vascular network. The tumor usually is bilateral and polycentric, and metastasizes to unusual sites. Late metastasis is common."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018492"
    }
  ],
  "roots": [
    {
      "id": 6742,
      "label": "clear cell adenocarcinoma"
    },
    {
      "id": 7199,
      "label": "renal cell adenocarcinoma"
    },
    {
      "id": 9112,
      "label": "nonpapillary renal cell carcinoma"
    }
  ]
}