{
  "id": 6746,
  "label": "colorectal adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005008",
  "properties": {
    "xrefs": [
      "DOID:0050861",
      "DOID:0050913",
      "EFO:0000365",
      "MEDGEN:230816",
      "NCIT:C5105",
      "ONCOTREE:COADREAD",
      "SCTID:408645001",
      "UMLS:C1319315"
    ],
    "synonyms": [
      "adenocarcinoma of large bowel",
      "adenocarcinoma of large intestine",
      "adenocarcinoma of the large bowel",
      "adenocarcinoma of the large intestine",
      "colorectal (colon or rectal) adenocarcinoma",
      "colorectal adenocarcinoma",
      "colorectum adenocarcinoma",
      "large bowel adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 21360,
      "label": "colorectal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7221,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080199",
          "EFO:1001951",
          "MEDGEN:3170",
          "NCIT:C2955",
          "UMLS:C0009402"
        ],
        "synonyms": [
          "cancer of large bowel",
          "cancer of large intestine",
          "cancer of the large bowel",
          "cancer of the large intestine",
          "colorectal (colon or rectal) cancer",
          "colorectal cancer",
          "large bowel cancer",
          "large intestine cancer",
          "CRC",
          "carcinoma of colorectum",
          "carcinoma of large bowel",
          "carcinoma of large intestine",
          "carcinoma of the large bowel",
          "carcinoma of the large intestine",
          "colorectal carcinoma",
          "colorectum carcinoma",
          "large bowel carcinoma",
          "large intestine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024331"
    }
  ],
  "children": [
    {
      "id": 4295,
      "label": "rectum adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1996",
          "EFO:0005631",
          "MEDGEN:56214",
          "NCIT:C9383",
          "ONCOTREE:READ",
          "SCTID:254582000",
          "UMLS:C0149978",
          "icd11.foundation:1316028436"
        ],
        "synonyms": [
          "adenocarcinoma - rectum",
          "adenocarcinoma of rectum",
          "adenocarcinoma of the rectum",
          "rectal adenocarcinoma",
          "rectum adenocarcinoma",
          "read"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002169"
    },
    {
      "id": 4386,
      "label": "colon adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4179,
        6746
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:234",
          "EFO:1001949",
          "MEDGEN:137834",
          "NCIT:C4349",
          "ONCOTREE:COAD",
          "UMLS:C0338106",
          "icd11.foundation:773139368"
        ],
        "synonyms": [
          "adenocarcinoma - colon",
          "adenocarcinoma of colon",
          "adenocarcinoma of the colon",
          "colon adenocarcinoma",
          "colonic adenocarcinoma",
          "COAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the colon"
      },
      "child_count": 10,
      "reference_id": "MONDO:0002271"
    },
    {
      "id": 7724,
      "label": "colorectal serrated adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6746
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000196",
          "ICDO:8213/3",
          "MEDGEN:474442",
          "NCIT:C96485",
          "UMLS:C3272809"
        ],
        "synonyms": [
          "colorectal serrated adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare, invasive colorectal adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006163"
    },
    {
      "id": 20193,
      "label": "colorectal medullary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:317525",
          "NCIT:C43590",
          "UMLS:C1707438"
        ],
        "synonyms": [
          "colorectal medullary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare, invasive colorectal adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020794"
    },
    {
      "id": 23338,
      "label": "colorectal signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:313040",
          "NCIT:C43586",
          "UMLS:C1707440"
        ],
        "synonyms": [
          "colorectal signet Ring cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive colorectal adenocarcinoma characterized by the presence of malignant glandular epithelial cells with prominent intracytoplasmic mucin resulting in the displacement of the nuclei. The malignant glandular cells with intracytoplasmic mucin constitute more than 50% of the malignant cellular infiltrate."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044336"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 21360,
      "label": "colorectal carcinoma"
    }
  ]
}