{
  "id": 6750,
  "label": "cutaneous melanoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005012",
  "properties": {
    "xrefs": [
      "DOID:8923",
      "EFO:0000389",
      "HP:0012056",
      "ICD10CM:C43",
      "ICD9:172",
      "ICD9:172.0",
      "ICD9:172.2",
      "ICD9:172.3",
      "ICD9:172.4",
      "ICD9:172.5",
      "ICD9:172.8",
      "ICD9:172.9",
      "MEDGEN:57486",
      "NCIT:C3510",
      "ONCOTREE:SKCM",
      "SCTID:93655004",
      "UMLS:C0151779"
    ],
    "synonyms": [
      "cutaneous (skin) melanoma",
      "cutaneous melanoma",
      "cutaneous melanoma (disease)",
      "malignant cutaneous melanoma",
      "malignant melanoma (of skin), stage unspecified",
      "malignant melanoma of skin",
      "malignant melanoma of skin stage unspecified",
      "melanoma (disease) of zone of skin",
      "melanoma of skin",
      "melanoma of the skin",
      "skin melanoma",
      "skin, melanoma",
      "zone of skin melanoma",
      "zone of skin melanoma (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 4907,
      "label": "skin cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        4599
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4159",
          "ICD10CM:C43-C44",
          "ICD9:173.8",
          "ICD9:173.9",
          "MEDGEN:40101",
          "NCIT:C2920",
          "SCTID:372130007",
          "UMLS:C0007114",
          "icd11.foundation:1706880799"
        ],
        "synonyms": [
          "cancer of zone of skin",
          "malignant neoplasm of skin",
          "malignant neoplasm of the skin",
          "malignant neoplasm of zone of skin",
          "malignant skin neoplasm",
          "malignant skin tumor",
          "malignant skin tumour",
          "malignant tumor of skin",
          "malignant tumor of the skin",
          "malignant tumour of skin",
          "malignant tumour of the skin",
          "malignant zone of skin neoplasm",
          "melanoma and non-melanoma skin cancer",
          "skin cancer",
          "skin cancer, Including melanoma",
          "skin neoplasm, malignant",
          "zone of skin cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the zone of skin"
      },
      "child_count": 26,
      "reference_id": "MONDO:0002898"
    },
    {
      "id": 6832,
      "label": "melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1909",
          "EFO:0000756",
          "HP:0002861",
          "ICDO:8720/3",
          "MEDGEN:9944",
          "MESH:D008545",
          "NANDO:2200077",
          "NCIT:C3224",
          "ONCOTREE:MEL",
          "Orphanet:411533",
          "SCTID:372244006",
          "UMLS:C0025202"
        ],
        "synonyms": [
          "malignant melanoma",
          "melanoma",
          "melanoma (disease)",
          "melanoma, malignant"
        ],
        "definition": "A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain."
      },
      "child_count": 15,
      "reference_id": "MONDO:0005105"
    },
    {
      "id": 20680,
      "label": "melanocytic skin neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4599,
        20380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:138096",
          "NCIT:C7161",
          "UMLS:C0349501"
        ],
        "synonyms": [
          "cutaneous melanocytic neoplasm",
          "melanocytic neoplasm of skin",
          "melanocytic neoplasm of zone of skin",
          "melanocytic skin neoplasm",
          "zone of skin melanocytic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A melanocytic neoplasm that involves the zone of skin."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021583"
    }
  ],
  "children": [
    {
      "id": 3198,
      "label": "eyelid melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750,
        7858,
        20495
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10040",
          "GARD:0022848",
          "ICD9:172.1",
          "MEDGEN:90937",
          "NCIT:C4358",
          "SCTID:231834005",
          "UMLS:C0339116"
        ],
        "synonyms": [
          "eyelid melanoma",
          "eyelid melanoma (disease)",
          "malignant eyelid melanoma",
          "malignant melanoma of eyelid",
          "malignant melanoma of the eyelid",
          "melanoma (disease) of eyelid",
          "melanoma of eyelid",
          "melanoma of the eyelid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma that arises from the upper or lower eyelid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000928"
    },
    {
      "id": 3199,
      "label": "balloon cell malignant melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10044",
          "ICDO:8722/3",
          "MEDGEN:90780",
          "NCIT:C4227",
          "SCTID:403922007",
          "UMLS:C0334426"
        ],
        "synonyms": [
          "balloon cell cutaneous (skin) melanoma",
          "balloon cell malignant melanoma of skin",
          "balloon cell malignant melanoma of the skin",
          "balloon cell malignant skin melanoma",
          "balloon cell melanoma",
          "balloon cell skin melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A rare variant of melanoma with a vertical growth phase. It presents as a nodular or polypoid skin lesion. It is characterized by the presence of nodules which contain large melanoma cells with clear, foamy or finely vacuolated cytoplasm. The prognosis is similar to that of other melanomas matched for depth of invasion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000929"
    },
    {
      "id": 3200,
      "label": "nodular malignant melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10047",
          "EFO:0008515",
          "GARD:0009961",
          "ICDO:8721/3",
          "MEDGEN:83144",
          "NCIT:C4225",
          "SCTID:254731001",
          "UMLS:C0334424"
        ],
        "synonyms": [
          "nodular cutaneous (skin) melanoma",
          "nodular malignant melanoma of skin",
          "nodular malignant melanoma of the skin",
          "nodular malignant skin melanoma",
          "nodular melanoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An aggressive form of melanoma, frequently metastasizing to the lymph nodes. It presents as a papular or nodular raised skin lesion. It comprises approximately 10-15% of melanomas. Morphologically, it often displays an epithelioid appearance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000930"
    },
    {
      "id": 5730,
      "label": "acral lentiginous melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6367",
          "HP:0012060",
          "ICDO:8744/3",
          "MEDGEN:87530",
          "NCIT:C4022",
          "ONCOTREE:ACRM",
          "SCTID:254732008",
          "UMLS:C0346037"
        ],
        "synonyms": [
          "acral lentiginous malignant melanoma",
          "acral lentiginous melanoma",
          "acral lentiginous melanoma (disease)",
          "acral lentiginous melanoma, malignant",
          "acral lentiginous melanoma, malignant (morphologic abnormality)",
          "ALM",
          "acral lentiginous malignant melanoma of skin",
          "acral melanoma",
          "palmar/plantar melanoma",
          "subungual melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A form of melanoma occurring most often on the plantar, palmar, subungual, and periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, it consists of atypical spindled and dendritic melanocytes. The epidermis is often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003865"
    },
    {
      "id": 6925,
      "label": "amelanotic skin melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4975,
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10054",
          "EFO:0002894",
          "MEDGEN:91149",
          "NCIT:C4633",
          "UMLS:C0349515",
          "Wikipedia:Amelanotic_melanoma"
        ],
        "synonyms": [
          "amelanotic cutaneous (skin) melanoma",
          "amelanotic malignant melanoma (of skin)",
          "amelanotic malignant melanoma of skin",
          "amelanotic malignant melanoma of the skin",
          "amelanotic malignant skin melanoma",
          "amelanotic melanoma of skin",
          "amelanotic melanoma of the skin",
          "amelanotic melanoma of zone of skin",
          "amelanotic skin melanoma",
          "skin amelanotic melanoma",
          "zone of skin amelanotic melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An amelanotic melanoma that involves the zone of skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005208"
    },
    {
      "id": 20053,
      "label": "superficial spreading melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8743/3",
          "MEDGEN:87242",
          "NCIT:C9152",
          "SCTID:254730000",
          "UMLS:C0334438",
          "icd11.foundation:208661037"
        ],
        "synonyms": [
          "SSM",
          "cutaneous superficial spreading melanoma",
          "pagetoid melanoma",
          "superficial spreading cutaneous (skin) melanoma",
          "superficial spreading malignant melanoma of skin",
          "superficial spreading malignant melanoma of the skin",
          "superficial spreading malignant skin melanoma",
          "superficial spreading melanoma",
          "superficial spreading melanoma of skin",
          "superficial spreading melanoma of the skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A type of melanoma that typically occurs in light-skinned individuals ranging in age from young adults to the elderly. Risk factors include extensive sun exposure during childhood, a family history of melanoma, and the presence of dysplastic nevi."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020638"
    },
    {
      "id": 21251,
      "label": "lentigo maligna melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:172.8",
          "ICDO:8742/3",
          "MEDGEN:439437",
          "NCIT:C9151",
          "ONCOTREE:SKLMM",
          "SCTID:302837001",
          "UMLS:C2739810",
          "icd11.foundation:2011782924"
        ],
        "synonyms": [
          "lentigo maligna melanoma",
          "malignant lentigo melanoma",
          "Hutchison melanotic freckle",
          "LMM",
          "SKLMM"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin cancer that usually develops in older, fair-skinned adults. The average age of diagnosis is 65. LMM is thought to be caused by a history of sun exposure to the affected area. Treatment includes surgery to remove as much of the LMM as possible."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023619"
    },
    {
      "id": 23439,
      "label": "desmoplastic melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750,
        7943,
        20076
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:232127",
          "NCIT:C37257",
          "ONCOTREE:DESM",
          "UMLS:C1333280"
        ],
        "synonyms": [
          "desmoplastic cutaneous (skin) melanoma",
          "desmoplastic melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044785"
    },
    {
      "id": 25139,
      "label": "spitzoid melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070326",
          "MEDGEN:1713307",
          "NCIT:C165497",
          "UMLS:C3495721"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850101"
    },
    {
      "id": 25148,
      "label": "melanoma in congenital melanocytic nevus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070327",
          "MEDGEN:313976",
          "NCIT:C48613",
          "UMLS:C1711221"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850110"
    }
  ],
  "roots": [
    {
      "id": 4907,
      "label": "skin cancer"
    },
    {
      "id": 6832,
      "label": "melanoma"
    },
    {
      "id": 20680,
      "label": "melanocytic skin neoplasm"
    }
  ]
}