{
  "id": 6758,
  "label": "ductal breast carcinoma in situ",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005023",
  "properties": {
    "xrefs": [
      "DOID:0060074",
      "EFO:0000432",
      "ICDO:8500/2",
      "MEDGEN:765",
      "MESH:D002285",
      "NCIT:C2924",
      "ONCOTREE:DCIS",
      "UMLS:C0007124"
    ],
    "synonyms": [
      "DCIS",
      "carcinoma in situ of mammary duct",
      "ductal breast carcinoma in situ",
      "ductal carcinoma in situ",
      "ductal carcinoma in situ (DCIS)",
      "ductal carcinoma in situ of breast",
      "ductal carcinoma in situ of the breast",
      "intraductal breast carcinoma",
      "intraductal carcinoma",
      "intraductal carcinoma of breast",
      "intraductal carcinoma of the breast",
      "mammary duct carcinoma in situ",
      "mammary duct in situ carcinoma",
      "non-infiltrating ductal adenocarcinoma of breast",
      "non-infiltrating ductal adenocarcinoma of the breast",
      "non-infiltrating ductal breast adenocarcinoma",
      "non-infiltrating ductal breast carcinoma",
      "non-infiltrating ductal carcinoma of breast",
      "non-infiltrating ductal carcinoma of the breast",
      "non-infiltrating intraductal adenocarcinoma",
      "non-infiltrating intraductal adenocarcinoma of breast",
      "non-infiltrating intraductal adenocarcinoma of the breast",
      "non-infiltrating intraductal breast adenocarcinoma",
      "non-infiltrating intraductal carcinoma",
      "non-invasive ductal adenocarcinoma of breast",
      "non-invasive ductal adenocarcinoma of the breast",
      "non-invasive ductal breast adenocarcinoma",
      "non-invasive ductal breast carcinoma",
      "non-invasive ductal carcinoma of breast",
      "non-invasive ductal carcinoma of the breast",
      "non-invasive intraductal adenocarcinoma of breast",
      "non-invasive intraductal adenocarcinoma of the breast",
      "non-invasive intraductal breast adenocarcinoma",
      "stage 0 mammary duct carcinoma",
      "breast ductal carcinoma in situ"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 5172,
      "label": "adenocarcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4943",
          "ICDO:8140/2",
          "MEDGEN:87203",
          "MESH:D065311",
          "NCIT:C4123",
          "ONCOTREE:AIS",
          "UMLS:C0334276"
        ],
        "synonyms": [
          "adenocarcinoma in situ",
          "AIS"
        ],
        "definition": "A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003218"
    },
    {
      "id": 5857,
      "label": "breast intraductal proliferative lesion",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4567
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6839",
          "MEDGEN:277343",
          "NCIT:C27942",
          "UMLS:C1334631"
        ],
        "synonyms": [
          "DIN",
          "ductal intraepithelial neoplasia",
          "intraductal proliferative lesion",
          "intraductal proliferative lesion of the breast",
          "mammary intraepithelial neoplasia, ductal type"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A group of non-invasive epithelial proliferations that occur in the ductal system of the breast. The vast majority of cases arise in the terminal ductal lobular units. This category includes atypical ductal hyperplasia, usual ductal hyperplasia, flat epithelial atypia, and ductal carcinoma in situ. There is an increased risk for subsequent development of invasive breast carcinoma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004007"
    },
    {
      "id": 6442,
      "label": "breast carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8791",
          "ICD10CM:D05",
          "ICD9:233.0",
          "MEDGEN:57817",
          "MESH:D000071960",
          "NCIT:C3641",
          "SCTID:189336000",
          "UMLS:C0154084",
          "icd11.foundation:1264360394"
        ],
        "synonyms": [
          "breast cancer in situ",
          "breast cancer stage 0",
          "breast carcinoma in situ",
          "breast in situ carcinoma",
          "carcinoma in situ of breast",
          "carcinoma in situ of the breast",
          "in situ breast cancer",
          "non-infiltrating breast carcinoma",
          "non-infiltrating carcinoma of breast",
          "non-infiltrating carcinoma of the breast",
          "non-invasive breast carcinoma",
          "non-invasive carcinoma of breast",
          "non-invasive carcinoma of the breast",
          "stage 0 breast cancer",
          "stage 0 breast cancer aJCC v6",
          "stage 0 breast cancer aJCC v6 and v7",
          "stage 0 breast cancer aJCC v7",
          "stage 0 breast carcinoma",
          "stage 0 breast carcinoma in situ",
          "stage 0 carcinoma of breast",
          "stage 0 carcinoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the breast."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004658"
    },
    {
      "id": 7234,
      "label": "breast ductal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3007",
          "EFO:0006318",
          "MEDGEN:315942",
          "MESH:D018270",
          "NCIT:C4017",
          "UMLS:C1527349"
        ],
        "synonyms": [
          "duct adenocarcinoma",
          "duct carcinoma",
          "ductal adenocarcinoma",
          "ductal carcinoma",
          "breast ductal carcinoma",
          "ductal breast adenocarcinoma",
          "ductal breast carcinoma",
          "ductal carcinoma of breast",
          "ductal carcinoma of the breast",
          "mammary duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast carcinoma arising from the ducts. While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast. Ductal carcinomas account for about two thirds of all breast cancers. Two types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. The latter often spreads to the axillary lymph nodes and other anatomic sites. The two forms of ductal carcinoma often coexist."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005590"
    }
  ],
  "children": [
    {
      "id": 23546,
      "label": "intraductal cribriform breast adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6758,
        23545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8201/2",
          "MEDGEN:233570",
          "NCIT:C5138",
          "UMLS:C1334248"
        ],
        "synonyms": [
          "DCIS of breast with cribriform pattern",
          "DCIS of the breast with cribriform pattern",
          "cribriform DCIS of breast",
          "cribriform DCIS of the breast",
          "cribriform ductal breast carcinoma in situ",
          "cribriform ductal carcinoma in situ of breast",
          "cribriform ductal carcinoma in situ of the breast",
          "ductal carcinoma in situ of breast with cribriform pattern",
          "ductal carcinoma in situ of the breast with cribriform pattern",
          "intraductal cribriform breast adenocarcinoma",
          "non-infiltrating cribriform ductal breast carcinoma",
          "non-invasive cribriform ductal breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A ductal carcinoma in situ of the breast characterized by the presence of a cribriform architectural pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0045060"
    }
  ],
  "roots": [
    {
      "id": 5172,
      "label": "adenocarcinoma in situ"
    },
    {
      "id": 5857,
      "label": "breast intraductal proliferative lesion"
    },
    {
      "id": 6442,
      "label": "breast carcinoma in situ"
    },
    {
      "id": 7234,
      "label": "breast ductal adenocarcinoma"
    }
  ]
}