{
  "id": 6761,
  "label": "epilepsy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005027",
  "properties": {
    "xrefs": [
      "DOID:1826",
      "EFO:0000474",
      "ICD10CM:G40",
      "ICD10WHO:G40",
      "ICD9:345",
      "ICD9:345.8",
      "ICD9:345.80",
      "ICD9:345.9",
      "ICD9:345.90",
      "ICD9:345.91",
      "MEDGEN:4506",
      "MESH:D004827",
      "NCIT:C3020",
      "SCTID:84757009",
      "UMLS:C0014544",
      "birnlex:12718"
    ],
    "synonyms": [
      "epilepsy",
      "seizure disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 7209,
      "label": "brain disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:936",
          "EFO:0005774",
          "ICD9:348.3",
          "ICD9:348.30",
          "ICD9:348.8",
          "ICD9:348.9",
          "MEDGEN:14214",
          "MESH:D001927",
          "NCIT:C96413",
          "SCTID:81308009",
          "UMLS:C0006111"
        ],
        "synonyms": [
          "brain disease",
          "brain disease or disorder",
          "disease of brain",
          "disease or disorder of brain",
          "disorder of brain",
          "encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease affecting the brain or part of the brain."
      },
      "child_count": 71,
      "reference_id": "MONDO:0005560"
    }
  ],
  "children": [
    {
      "id": 4442,
      "label": "extratemporal epilepsy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2544",
          "ICD9:345.80",
          "MEDGEN:78737",
          "NCIT:C7760",
          "SCTID:111498005",
          "UMLS:C0270849"
        ],
        "synonyms": [
          "extratemporal epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An epilepsy syndrome that is located in an area of the brain other than the temporal lobe."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002338"
    },
    {
      "id": 7064,
      "label": "focal epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2234",
          "EFO:0004263",
          "ICD9:345.50",
          "MEDGEN:41836",
          "MESH:D004828",
          "NCIT:C122812",
          "SCTID:230381009",
          "UMLS:C0014547"
        ],
        "synonyms": [
          "focal epilepsy",
          "partial epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A seizure caused by a localized disorder."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005384"
    },
    {
      "id": 16436,
      "label": "epilepsy syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020083",
          "MEDGEN:1371141",
          "Orphanet:166463",
          "UMLS:C4505072"
        ],
        "synonyms": [
          "epileptic syndrome",
          "syndromic epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A syndrome that has a characteristic cluster of clinical features and/or lectroencephalographic (EEG) findings that reflect underlying epileptic activity. It is often associated with a range of other health issues, including cognitive impairment, intellectual disability, physical gross motor and fine motor delays, speech and language deficits, and impacts to other bodily functions and may be supported by specific etiological findings—such as structural, genetic, metabolic, immune, or infectious causes or have an unknown etiology."
      },
      "child_count": 8,
      "reference_id": "MONDO:0015650"
    },
    {
      "id": 16437,
      "label": "monogenic epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020086",
          "MEDGEN:1842675",
          "Orphanet:166472",
          "UMLS:C5680430"
        ],
        "synonyms": [
          "monogenic disease with epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 18,
      "reference_id": "MONDO:0015653"
    },
    {
      "id": 17993,
      "label": "reflex epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2548",
          "EFO:1001146",
          "GARD:0018688",
          "ICD9:345.10",
          "MEDGEN:75726",
          "MESH:D020195",
          "NCIT:C85041",
          "Orphanet:310",
          "SCTID:79745005",
          "UMLS:C0270857",
          "icd11.foundation:276807111"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Reflex epilepsy refers to epilepsies where recurrent seizures are provoked by a clearly defined extrinsic (most commonly) or intrinsic triggering stimuli such as flashing lights (photosensitive epilepsy), startling noises (startle epilepsy), urinating (micturition induced seizures), exposure to hot-water (hot water epilepsy), eating, reading, and thinking, while being associated with an enduring abnormal predisposition to have such seizures (thereby meeting the conceptual definition of epilepsy)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0017768"
    },
    {
      "id": 23178,
      "label": "post-traumatic epilepsy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:4991",
          "MESH:D004834",
          "SCTID:75023009",
          "UMLS:C0014557"
        ],
        "synonyms": [
          "post-traumatic epilepsy",
          "Epilepsies, post-traumatic",
          "Epilepsies, traumatic",
          "PTE - post-traumatic epilepsy",
          "concussive convulsion",
          "concussive convulsions",
          "convulsion, concussive",
          "convulsions, concussive",
          "disorder, post-traumatic seizure",
          "disorders, post-traumatic seizure",
          "early post traumatic seizures",
          "early post-traumatic seizure",
          "early post-traumatic seizures",
          "epilepsy, post traumatic",
          "epilepsy, traumatic",
          "impact seizure",
          "impact seizures",
          "late post traumatic seizures",
          "late post-traumatic seizure",
          "late post-traumatic seizures",
          "post traumatic seizure disorder",
          "post-traumatic Epilepsies",
          "post-traumatic seizure disorder",
          "post-traumatic seizure disorders",
          "post-traumatic seizure, early",
          "post-traumatic seizure, late",
          "post-traumatic seizures, early",
          "post-traumatic seizures, late",
          "seizure disorder, post traumatic",
          "seizure disorder, post-traumatic",
          "seizure disorders, post-traumatic",
          "seizure, early post-traumatic",
          "seizure, late post-traumatic",
          "seizures, early post-traumatic",
          "seizures, late post-traumatic",
          "traumatic Epilepsies",
          "traumatic epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0043264"
    },
    {
      "id": 23785,
      "label": "immune epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1371634",
          "UMLS:C4510729"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Epilepsies that have a distinct immune-mediated etiology with evidence of central nervous system inflammation, that has been demonstrated to be associated with a substantially increased risk of developing epilepsy."
      },
      "child_count": 2,
      "reference_id": "MONDO:0100028"
    },
    {
      "id": 23787,
      "label": "metabolic epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1843497",
          "UMLS:C4524099"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Metabolic epilepsies are conceptualized as having a distinct metabolic abnormality that has been demonstrated to be associated with a substantially increased risk of developing epilepsy in appropriately designed studies. Metabolic disorders have genetic origin; however, the metabolic abnormalities are a separate disorder interposed between the genetic defect and the epilepsy."
      },
      "child_count": 4,
      "reference_id": "MONDO:0100033"
    },
    {
      "id": 23789,
      "label": "structural epilepsy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1843494",
          "UMLS:C4524097"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A type of epilepsy that is conceptualized as having a distinct structural brain abnormality that has been demonstrated to be associated with a substantially increased risk of epilepsy in appropriately designed studies. The structural brain abnormality can be acquired (such as due to stroke, trauma or infection) or may be of genetic origin; however, as we currently understand it, the structural brain abnormality is a separate disorder interposed between the acquired or genetic defect and the epilepsy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100035"
    },
    {
      "id": 23948,
      "label": "infantile-onset epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Epilepsy starting in the first 12 months of life, including self-limiting and refractory seizures, and epilepsies with and without developmental disorders."
      },
      "child_count": 2,
      "reference_id": "MONDO:0100207"
    },
    {
      "id": 24298,
      "label": "generalized epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:4507",
          "NCIT:C3021",
          "UMLS:C0014548"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Epilepsy that is characterized by generalized seizure types and may have typical interictal and/or ictal EEG findings that accompany generalized seizure types (for example generalized spike-wave)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0100574"
    },
    {
      "id": 24304,
      "label": "epilepsy, unknown whether focal or generalized",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "epilepsy, focal or generalized unknown",
          "epilepsy, onset unknown",
          "epilepsy, unclassified"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An epilepsy in which the type of seizure onset is unknown or unclear, making it uncertain whether it is a generalized or focal epilepsy. Seizures of unknown onset may still have features that can be classified."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100580"
    },
    {
      "id": 24340,
      "label": "developmental and epileptic encephalopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761,
        23791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027373",
          "MEDGEN:1830477",
          "UMLS:C5779964"
        ],
        "synonyms": [
          "DEE",
          "developmental and epileptic encephalopathy",
          "infantile spasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An epilepsy associated with developmental impairment that may be due to either the underlying etiology or the superimposed epileptic activity, or both."
      },
      "child_count": 6,
      "reference_id": "MONDO:0100620"
    }
  ],
  "roots": [
    {
      "id": 7209,
      "label": "brain disorder"
    }
  ]
}