{
  "id": 6762,
  "label": "esophageal adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005028",
  "properties": {
    "xrefs": [
      "DOID:4914",
      "EFO:0000478",
      "GARD:0016927",
      "MEDGEN:124636",
      "NCIT:C4025",
      "ONCOTREE:ESCA",
      "Orphanet:99976",
      "SCTID:276803003",
      "UMLS:C0279628",
      "icd11.foundation:829915640"
    ],
    "synonyms": [
      "adenocarcinoma - esophagus",
      "adenocarcinoma - oesophagus",
      "adenocarcinoma of esophagus",
      "adenocarcinoma of oesophagus",
      "adenocarcinoma of the esophagus",
      "adenocarcinoma of the oesophagus",
      "esophageal adenocarcinoma",
      "esophagus adenocarcinoma",
      "oesophageal adenocarcinoma",
      "oesophagus adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7738,
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1107",
          "EFO:0002916",
          "GARD:0006383",
          "MEDGEN:56256",
          "MedDRA:10030155",
          "NCIT:C3513",
          "Orphanet:70482",
          "SCTID:372138000",
          "UMLS:C0152018"
        ],
        "synonyms": [
          "Esophageal cancer",
          "carcinoma of esophagus",
          "carcinoma of the esophagus",
          "carcinoma of the oesophagus",
          "esophageal carcinoma",
          "esophagus carcinoma",
          "oesophagus carcinoma",
          "cancer of esophagus",
          "cancer of oesophagus",
          "cancer of the esophagus",
          "cancer of the oesophagus",
          "esophageal cancer",
          "esophageal cancer, NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0019086"
    }
  ],
  "children": [
    {
      "id": 5079,
      "label": "mucoepidermoid esophageal carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5029,
        6762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4686",
          "GARD:0023366",
          "MEDGEN:234232",
          "NCIT:C5343",
          "UMLS:C1333461"
        ],
        "synonyms": [
          "esophagus mucoepidermoid carcinoma",
          "mucoepidermoid carcinoma of the esophagus",
          "mucoepidermoid carcinoma of the oesophagus",
          "oesophagus mucoepidermoid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare carcinoma of the esophagus which contains squamous cells, mucus secreting cells, and cells of an intermediate type. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003093"
    },
    {
      "id": 5146,
      "label": "esophageal adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4878",
          "GARD:0023403",
          "MEDGEN:232468",
          "NCIT:C5342",
          "UMLS:C1333441"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of esophagus",
          "adenoid cystic carcinoma of oesophagus",
          "adenoid cystic carcinoma of the esophagus",
          "adenoid cystic carcinoma of the oesophagus",
          "adenoid cystic carcinoma, esophagus",
          "adenoid cystic carcinoma, oesophagus",
          "adenoid cystic esophagus carcinoma",
          "adenoid cystic oesophagus carcinoma",
          "esophageal adenoid cystic cancer",
          "esophageal adenoid cystic carcinoma",
          "esophagus adenoid cystic carcinoma",
          "oesophagus adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An infrequent esophageal carcinoma arising from esophageal glands. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003186"
    },
    {
      "id": 6214,
      "label": "Barrett adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7941",
          "EFO:1001939",
          "GARD:0023984",
          "MEDGEN:272350",
          "NCIT:C7027",
          "SCTID:721617001",
          "UMLS:C1332460",
          "icd11.foundation:1934528268"
        ],
        "synonyms": [
          "Barrett adenocarcinoma",
          "Barrett's adenocarcinoma",
          "adenocarcinoma arising in Barrett's mucosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from Barrett metaplastic epithelium in the esophagus. There is evidence supporting the idea that the Barrett adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy. Adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. In terms of grading, they are well or moderately differentiated adenocarcinomas. -- 2002"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004405"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus"
    }
  ]
}