{
  "id": 6767,
  "label": "ganglioneuroma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005033",
  "properties": {
    "xrefs": [
      "DOID:4817",
      "EFO:0000500",
      "GARD:0020731",
      "HP:0003005",
      "ICD9:215.9",
      "ICDO:9490/0",
      "MEDGEN:6545",
      "MedDRA:10017709",
      "NCIT:C3049",
      "ONCOTREE:GN",
      "Orphanet:251992",
      "SCTID:116371000119107",
      "UMLS:C0017075",
      "birnlex:12617"
    ],
    "synonyms": [
      "ganglioneuroma",
      "ganglioneuroma (Schwannian Stroma-dominant)",
      "ganglioneuroma (disease)",
      "ganglioneuroma, benign",
      "neural Crest tumor, benign",
      "GN"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A benign neuroblastic tumor of the sympathetic nervous system that occurs in childhood. Ganglioneuroma typically arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 3043,
      "label": "central nervous system primitive neuroectodermal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        7121
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060103",
          "GARD:0027536",
          "MEDGEN:854517",
          "NANDO:2200099",
          "NANDO:2200100",
          "NCIT:C5398",
          "UMLS:C3887678",
          "icd11.foundation:1711526170"
        ],
        "synonyms": [
          "CNS PNET",
          "CNS primitive neuroectodermal neoplasm",
          "CNS primitive neuroectodermal tumor",
          "CNS primitive neuroectodermal tumour",
          "central nervous system PNET",
          "central nervous system neuroectodermal tumor",
          "central nervous system neuroectodermal tumour",
          "central nervous system primitive neuroectodermal neoplasm",
          "central nervous system primitive neuroectodermal tumor",
          "central nervous system primitive neuroectodermal tumor (WHO grade IV)",
          "central nervous system primitive neuroectodermal tumour",
          "central nervous system primitive neuroectodermal tumour (WHO grade IV)",
          "central primitive neuroectodermal neoplasm",
          "central primitive neuroectodermal tumor",
          "central primitive neuroectodermal tumour",
          "primitive neuroectodermal tumor of central nervous system",
          "primitive neuroectodermal tumour of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroectodermal tumor that involves the central nervous system."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000640"
    },
    {
      "id": 4464,
      "label": "autonomic nervous system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3525,
        3627,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2621",
          "MEDGEN:231389",
          "NCIT:C5112",
          "UMLS:C1332356"
        ],
        "synonyms": [
          "autonomic nervous system neoplasm",
          "autonomic nervous system neoplasm (disease)",
          "autonomic nervous system neoplasms",
          "autonomic nervous system tumor",
          "autonomic nervous system tumour",
          "neoplasm of autonomic nervous system",
          "neoplasm of the autonomic nervous system",
          "tumor of autonomic nervous system",
          "tumor of the autonomic nervous system",
          "tumour of autonomic nervous system",
          "tumour of the autonomic nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Benign and malignant neoplasms which arise from or directly involve the central or peripheral elements of the autonomic nervous system."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002366"
    },
    {
      "id": 7851,
      "label": "neuroblastic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7121
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000393",
          "MEDGEN:233228",
          "NCIT:C6963",
          "UMLS:C1334953"
        ],
        "synonyms": [
          "neuroblastic tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of nervous system tumors which display neuronal differentiation. It includes tumors that are composed of immature round cells and tumors that display advanced differentiation and the formation of ganglion cells."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006316"
    },
    {
      "id": 17182,
      "label": "mixed neuronal-glial tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20418
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020728",
          "MEDGEN:105377",
          "NCIT:C4747",
          "Orphanet:251934",
          "UMLS:C0474844",
          "icd11.foundation:1792897751"
        ],
        "synonyms": [
          "neuronal and Glio-neuronal neoplasm",
          "neuronal and Glio-neuronal tumor",
          "neuronal and Glio-neuronal tumour",
          "neuronal and mixed neuronal-glial tumor",
          "neuronal and mixed neuronal-glial tumors",
          "neuronal and mixed neuronal-glial tumour",
          "neuronal and mixed neuronal-glial tumours"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of central nervous system neoplasms with a variable amount of neuronal and, less consistently, glial differentiation. They occur at a low frequency and usually carry a favorable prognosis. Representative examples include dysplastic cerebellar gangliocytoma, desmoplastic infantile ganglioglioma, desmoplastic infantile astrocytoma, and dysembryoplastic neuroepithelial tumor. (Adapted from WHO)"
      },
      "child_count": 12,
      "reference_id": "MONDO:0016729"
    },
    {
      "id": 20329,
      "label": "peripheral nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3627,
        7479
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:171.9",
          "MEDGEN:155556",
          "NCIT:C4961",
          "SCTID:254986007",
          "UMLS:C0751428"
        ],
        "synonyms": [
          "cancer of peripheral nervous system",
          "malignant PNS neoplasm",
          "malignant PNS tumor",
          "malignant PNS tumour",
          "malignant neoplasm of PNS",
          "malignant neoplasm of peripheral nerve",
          "malignant neoplasm of peripheral nervous system",
          "malignant neoplasm of the PNS",
          "malignant neoplasm of the peripheral nerve",
          "malignant neoplasm of the peripheral nervous system",
          "malignant neoplasms, peripheral nerve",
          "malignant peripheral nerve neoplasm",
          "malignant peripheral nerve tumor",
          "malignant peripheral nerve tumour",
          "malignant peripheral nervous system neoplasm",
          "malignant peripheral nervous system tumor",
          "malignant peripheral nervous system tumour",
          "malignant tumor of PNS",
          "malignant tumor of peripheral nerve",
          "malignant tumor of peripheral nervous system",
          "malignant tumor of the PNS",
          "malignant tumor of the peripheral nerve",
          "malignant tumor of the peripheral nervous system",
          "malignant tumour of PNS",
          "malignant tumour of peripheral nerve",
          "malignant tumour of peripheral nervous system",
          "malignant tumour of the PNS",
          "malignant tumour of the peripheral nerve",
          "malignant tumour of the peripheral nervous system",
          "peripheral nervous system cancer",
          "peripheral nervous system neoplasms, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location"
      },
      "child_count": 36,
      "reference_id": "MONDO:0021089"
    },
    {
      "id": 23497,
      "label": "sympathetic nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:148206",
          "SCTID:50330009",
          "UMLS:C0750946"
        ],
        "synonyms": [
          "disease of sympathetic nervous system",
          "disease or disorder of sympathetic nervous system",
          "disorder of sympathetic nervous system",
          "sympathetic nervous system disease",
          "sympathetic nervous system disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the sympathetic nervous system."
      },
      "child_count": 2,
      "reference_id": "MONDO:0044993"
    }
  ],
  "children": [
    {
      "id": 4404,
      "label": "cutaneous ganglioneuroma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4907,
        6767
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2425",
          "GARD:0023108",
          "MEDGEN:91077",
          "NCIT:C4481",
          "SCTID:254766004",
          "UMLS:C0346063"
        ],
        "synonyms": [
          "cutaneous ganglioneuroma",
          "ganglioneuroma of skin",
          "ganglioneuroma of the skin",
          "skin ganglioneuroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A ganglioneuroma arising from the skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002293"
    }
  ],
  "roots": [
    {
      "id": 3043,
      "label": "central nervous system primitive neuroectodermal neoplasm"
    },
    {
      "id": 4464,
      "label": "autonomic nervous system neoplasm"
    },
    {
      "id": 7851,
      "label": "neuroblastic tumor"
    },
    {
      "id": 17182,
      "label": "mixed neuronal-glial tumor"
    },
    {
      "id": 20329,
      "label": "peripheral nervous system cancer"
    },
    {
      "id": 23497,
      "label": "sympathetic nervous system disorder"
    }
  ]
}