{
  "id": 6768,
  "label": "thyroid gland follicular carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005034",
  "properties": {
    "xrefs": [
      "DOID:3962",
      "EFO:0000501",
      "GARD:0024144",
      "HP:0006731",
      "ICDO:8330/3",
      "ICDO:8331/3",
      "MEDGEN:64630",
      "MESH:D018263",
      "NCIT:C8054",
      "ONCOTREE:THFO",
      "SCTID:255028004",
      "UMLS:C0206682"
    ],
    "synonyms": [
      "follicular cancer of the thyroid",
      "follicular cancer of the thyroid gland",
      "follicular cancer of thyroid",
      "follicular cancer of thyroid gland",
      "thyroid gland follicular cancer",
      "well-differentiated follicular carcinoma",
      "carcinoma of thyroid follicle",
      "carcinoma, follicular cell, malignant",
      "follicular carcinoma",
      "follicular carcinoma of the thyroid",
      "follicular carcinoma of the thyroid gland",
      "follicular carcinoma of thyroid",
      "follicular carcinoma of thyroid gland",
      "follicular thyroid cancer",
      "follicular thyroid carcinoma",
      "follicular thyroid gland carcinoma",
      "thyroid follicle carcinoma",
      "thyroid follicular carcinoma",
      "thyroid gland follicular carcinoma",
      "well-differentiated follicular adenocarcinoma",
      "follicular adenocarcinoma",
      "follicular adenocarcinoma (morphologic abnormality)",
      "follicular adenocarcinoma, well differentiated",
      "follicular adenocarcinoma, well differentiated (morphologic abnormality)",
      "thyroid gland adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. The nuclear features which characterize the thyroid gland papillary carcinoma are absent. Radiation exposure is a risk factor and it comprises approximately 10% to 15% of thyroid cancers. Clinically, it usually presents as a solitary mass in the thyroid gland. It is generally unifocal and thickly encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures include thyroid ultrasound and fine needle biopsy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 16290,
      "label": "differentiated thyroid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080525",
          "EFO:1002017",
          "GARD:0012027",
          "MEDGEN:277876",
          "NCIT:C7153",
          "ONCOTREE:WDTC",
          "Orphanet:146",
          "UMLS:C1337013"
        ],
        "synonyms": [
          "differentiated thyroid cancer",
          "differentiated thyroid carcinoma",
          "differentiated thyroid gland cancer",
          "differentiated thyroid gland carcinoma",
          "papillary or follicular thyroid carcinoma",
          "thyroid gland differentiated carcinoma",
          "thyroid gland well differentiated carcinoma",
          "well differentiated thyroid carcinoma",
          "well differentiated thyroid gland carcinoma",
          "well-differentiated thyroid cancer",
          "well-differentiated thyroid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Differentiated thyroid carcinoma (DTC), also known as papillary or follicular thyroid carcinoma, is a slow-growing malignancy usually presenting in adults as an asymptomatic thyroid mass."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015447"
    },
    {
      "id": 21537,
      "label": "thyroid gland adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080524",
          "GARD:0025440",
          "MEDGEN:309935",
          "NCIT:C27380",
          "UMLS:C1704228"
        ],
        "synonyms": [
          "thyroid adenocarcinoma",
          "thyroid gland adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024622"
    }
  ],
  "children": [
    {
      "id": 4844,
      "label": "trabecular follicular adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3964",
          "GARD:0023254",
          "MEDGEN:569646",
          "UMLS:C0334327"
        ],
        "synonyms": [
          "follicular adenocarcinoma, trabecular (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002821"
    },
    {
      "id": 8324,
      "label": "thyroid gland papillary and follicular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6768,
        6803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3968",
          "EFO:1001083",
          "GARD:0024498",
          "MEDGEN:64631",
          "MESH:D018265",
          "NCIT:C7380",
          "UMLS:C0206683"
        ],
        "synonyms": [
          "papillary and follicular adenocarcinoma",
          "papillary and follicular carcinoma",
          "thyroid gland papillary and follicular carcinoma",
          "papillary follicular thyroid adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0006886"
    },
    {
      "id": 9853,
      "label": "thyroid cancer, nonmedullary, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6768,
        18105
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005206",
          "MEDGEN:904175",
          "MESH:C572845",
          "OMIM:188470",
          "UMLS:C4225426"
        ],
        "synonyms": [
          "thyroid cancer, nonmedullary, 2",
          "thyroid cancer, nonmedullary, 2, autosomal dominant, somatic mutation",
          "thyroid cancer, nonmedullary, type 2",
          "thyroid carcinoma, follicular, autosomal dominant, somatic mutation",
          "thyroid carcinoma, follicular, somatic",
          "FTC",
          "NMTC2",
          "thyroid cancer, follicular",
          "thyroid carcinoma, follicular"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008566"
    },
    {
      "id": 12917,
      "label": "thyroid Hurthle cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8161",
          "GARD:0009428",
          "MEDGEN:196672",
          "MESH:C536913",
          "NCIT:C4946",
          "OMIM:607464",
          "ONCOTREE:THHC",
          "SCTID:423158009",
          "UMLS:C0749424"
        ],
        "synonyms": [
          "Hurthle cell carcinoma of the thyroid",
          "Hurthle cell carcinoma of the thyroid gland",
          "Hurthle cell carcinoma of thyroid",
          "Hurthle cell carcinoma of thyroid gland",
          "Hurthle cell thyroid gland carcinoma",
          "oncocytic carcinoma of the thyroid",
          "oncocytic carcinoma of thyroid",
          "thyroid Hurthle cell carcinoma",
          "thyroid carcinoma, Hurthle cell",
          "thyroid gland Hurthle cell carcinoma",
          "thyroid gland oncocytic follicular carcinoma",
          "thyroid oncocytic carcinoma",
          "Hurthle cell thyroid cancer",
          "Hurthle cell thyroid neoplasia",
          "follicular thyroid cancer, Hurthle cell type",
          "thyroid cancer, Hurthle cell",
          "thyroid cancer, follicular, Hurthle cell type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011836"
    },
    {
      "id": 15676,
      "label": "thyroid cancer, nonmedullary, 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6768,
        18105
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016132",
          "MEDGEN:907624",
          "OMIM:616534",
          "UMLS:C4225293"
        ],
        "synonyms": [
          "FOXE1 thyroid cancer, nonmedullary",
          "thyroid cancer, nonmedullary caused by mutation in FOXE1",
          "thyroid cancer, nonmedullary, 4",
          "thyroid cancer, nonmedullary, type 4",
          "NMTC4"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any thyroid cancer, nonmedullary in which the cause of the disease is a mutation in the FOXE1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014681"
    },
    {
      "id": 15677,
      "label": "thyroid cancer, nonmedullary, 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6768,
        18105
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016133",
          "MEDGEN:895900",
          "OMIM:616535",
          "UMLS:C4225292"
        ],
        "synonyms": [
          "HABP2 thyroid cancer, nonmedullary",
          "thyroid cancer, nonmedullary caused by mutation in HABP2",
          "thyroid cancer, nonmedullary, 5",
          "thyroid cancer, nonmedullary, type 5",
          "NMTC5"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any thyroid cancer, nonmedullary in which the cause of the disease is a mutation in the HABP2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014682"
    },
    {
      "id": 16159,
      "label": "medullary thyroid gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3973",
          "GARD:0007004",
          "HP:0002865",
          "MEDGEN:66772",
          "MedDRA:10027101",
          "NANDO:2201054",
          "NCIT:C3879",
          "ONCOTREE:THME",
          "Orphanet:1332",
          "SCTID:255032005",
          "UMLS:C0238462",
          "icd11.foundation:578519098"
        ],
        "synonyms": [
          "C cell carcinoma",
          "MTC",
          "carcinoma of parafollicular cell",
          "carcinoma, C-cell, malignant",
          "medullary carcinoma",
          "medullary carcinoma of the thyroid",
          "medullary carcinoma of the thyroid gland",
          "medullary carcinoma of thyroid",
          "medullary carcinoma of thyroid gland",
          "medullary thyroid cancer",
          "medullary thyroid carcinoma",
          "medullary thyroid gland carcinoma",
          "parafollicular cell carcinoma",
          "thyroid gland medullary cancer",
          "thyroid gland medullary carcinoma",
          "thyroid gland neuroendocrine carcinoma",
          "thyroid medullary carcinoma",
          "THME",
          "medullary thyroid cancer (MTC)",
          "thyroid cancer, medullary",
          "thyroid carcinoma, medullary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015277"
    }
  ],
  "roots": [
    {
      "id": 16290,
      "label": "differentiated thyroid carcinoma"
    },
    {
      "id": 21537,
      "label": "thyroid gland adenocarcinoma"
    }
  ]
}