{
  "id": 6770,
  "label": "gastric adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005036",
  "properties": {
    "xrefs": [
      "DOID:3717",
      "EFO:0000503",
      "GARD:0027713",
      "MEDGEN:82961",
      "NCIT:C4004",
      "ONCOTREE:STAD",
      "Orphanet:464463",
      "SCTID:408647009",
      "UMLS:C0278701",
      "icd11.foundation:1855471719"
    ],
    "synonyms": [
      "adenocarcinoma - stomach",
      "adenocarcinoma of stomach",
      "adenocarcinoma of the stomach",
      "gastric (stomach) adenocarcinoma",
      "gastric adenocarcinoma",
      "stomach adenocarcinoma",
      "STAD"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A carcinoma that arises from glandular epithelial cells of the stomach"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6695,
      "label": "gastric carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3312,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10538",
          "DOID:5517",
          "EFO:0000178",
          "GARD:0027710",
          "ICD9:151.3",
          "MEDGEN:147066",
          "NCIT:C4911",
          "SCTID:187741001",
          "UMLS:C0699791",
          "icd11.foundation:1503707183"
        ],
        "synonyms": [
          "cancer of stomach",
          "cancer of the stomach",
          "gastric (stomach) cancer",
          "gastric cancer",
          "gastric cancer, NOS",
          "stomach cancer",
          "carcinoma of stomach",
          "carcinoma of the stomach",
          "gastric carcinoma",
          "stomach carcinoma",
          "Ca fundus - stomach",
          "cancer of fundus of stomach",
          "fundus of stomach cancer",
          "gastric fundus cancer",
          "malignant fundus of stomach neoplasm",
          "malignant neoplasm of fundus of stomach",
          "malignant tumor of fundus of stomach",
          "malignant tumour of fundus of stomach"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the stomach."
      },
      "child_count": 24,
      "reference_id": "MONDO:0004950"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    }
  ],
  "children": [
    {
      "id": 3315,
      "label": "microinvasive gastric cancer",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6770
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10541",
          "GARD:0027565",
          "MEDGEN:138098",
          "NCIT:C27131",
          "SCTID:276809004",
          "UMLS:C0349530"
        ],
        "synonyms": [
          "EGC",
          "early gastric cancer",
          "superficial gastric cancer",
          "superficial spreading gastric cancer",
          "surface gastric cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma confined to the mucosa or mucosa and submucosa of the gastric wall. The regional lymph nodes may or may not be involved. It usually occurs in the lesser curvature. The 5-year survival rate following resection is between 80 percent and 95 percent, and remains high even when lymph node metastases are present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001060"
    },
    {
      "id": 5703,
      "label": "gastric cardia adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5702,
        6770
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6271",
          "GARD:0027650",
          "MEDGEN:232543",
          "NCIT:C5247",
          "UMLS:C1333762",
          "icd11.foundation:323129890"
        ],
        "synonyms": [
          "adenocarcinoma of cardia of stomach",
          "adenocarcinoma of the cardia of the stomach",
          "adenocarcinoma of the gastric cardia",
          "cardia of stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the cardia of stomach."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003835"
    },
    {
      "id": 6754,
      "label": "diffuse gastric adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6770,
        20704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6217",
          "EFO:0000402",
          "GARD:0027712",
          "MEDGEN:79019",
          "NCIT:C9159",
          "ONCOTREE:DSTAD",
          "UMLS:C0279635"
        ],
        "synonyms": [
          "adenocarcinoma of linitis plastica type",
          "adenocarcinoma of the linitis plastica type",
          "carcinoma, diffuse type",
          "carcinoma, diffuse type (morphologic abnormality)",
          "diffuse adenocarcinoma of stomach",
          "diffuse adenocarcinoma of the stomach",
          "diffuse gastric adenocarcinoma",
          "diffuse stomach adenocarcinoma",
          "gastric diffuse adenocarcinoma",
          "stomach diffuse type adenocarcinoma",
          "diffuse type stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the stomach. Microscopically, it is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. Many cells contain mucin droplets, producing a signet-ring configuration."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005017"
    },
    {
      "id": 6771,
      "label": "gastric intestinal type adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6770,
        7430,
        7801
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000504",
          "GARD:0027714",
          "MEDGEN:79017",
          "NCIT:C9157",
          "ONCOTREE:ISTAD",
          "UMLS:C0279633"
        ],
        "synonyms": [
          "gastric intestinal type adenocarcinoma",
          "gastric intestinal-type adenocarcinoma",
          "intestinal adenocarcinoma of stomach",
          "intestinal adenocarcinoma of the stomach",
          "intestinal gastric adenocarcinoma",
          "intestinal stomach adenocarcinoma",
          "intestinal type stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma of the stomach arising on a background of intestinal metaplasia. Microscopically, it is characterized by a glandular pattern and it closely resembles a colonic adenocarcinoma. Grossly, it tends to be nodular, polypoid or ulcerated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005037"
    },
    {
      "id": 7621,
      "label": "gastric tubular adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6770,
        7247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6595",
          "EFO:1000030",
          "GARD:0027735",
          "MEDGEN:234303",
          "NCIT:C5473",
          "ONCOTREE:TSTAD",
          "UMLS:C1333791"
        ],
        "synonyms": [
          "gastric tubular adenocarcinoma",
          "stomach tubular adenocarcinoma",
          "tubular adenocarcinoma of stomach",
          "tubular adenocarcinoma of the stomach",
          "tubular stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A variant of gastric adenocarcinoma characterized by prominent dilated or slit-like tubules."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006035"
    },
    {
      "id": 7781,
      "label": "gastric papillary adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        6770
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5593",
          "EFO:1000276",
          "GARD:0027744",
          "MEDGEN:232550",
          "NCIT:C5472",
          "ONCOTREE:PSTAD",
          "UMLS:C1333785"
        ],
        "synonyms": [
          "gastric papillary adenocarcinoma",
          "papillary adenocarcinoma of stomach",
          "papillary adenocarcinoma of the stomach",
          "stomach papillary adenocarcinoma",
          "papillary stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A variant of gastric adenocarcinoma with exophytic growth and elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006228"
    },
    {
      "id": 7846,
      "label": "mucinous gastric adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6700,
        6770
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3716",
          "EFO:1000386",
          "GARD:0027748",
          "MEDGEN:235338",
          "NCIT:C5248",
          "ONCOTREE:MSTAD",
          "UMLS:C1334809"
        ],
        "synonyms": [
          "mucinous adenocarcinoma of stomach",
          "mucinous adenocarcinoma of the stomach",
          "mucinous gastric adenocarcinoma",
          "mucinous stomach adenocarcinoma",
          "stomach mucinous adenocarcinoma",
          "MSTAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A variant of gastric adenocarcinoma with more than half of the tumor containing extracellular mucinous pools."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006309"
    },
    {
      "id": 7928,
      "label": "signet ring cell gastric adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6770,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8025",
          "EFO:1000524",
          "GARD:0027754",
          "MEDGEN:234782",
          "NCIT:C5250",
          "ONCOTREE:SSRCC",
          "UMLS:C1335965"
        ],
        "synonyms": [
          "gastric signet Ring cell adenocarcinoma",
          "gastric signet ring cell adenocarcinoma",
          "signet Ring cell adenocarcinoma of stomach",
          "signet Ring cell adenocarcinoma of the stomach",
          "signet Ring cell stomach adenocarcinoma",
          "signet ring cell gastric adenocarcinoma",
          "signet ring cell carcinoma of the stomach"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006409"
    },
    {
      "id": 23994,
      "label": "CTNNA1-related diffuse gastric and lobular breast cancer syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2991,
        6770,
        16935,
        18536
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026099"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Germline pathogenic or likely pathogenic variants in the CTNNA1 gene predispose to hereditary diffuse gastric cancer and lobular breast cancer, a cancer susceptibility syndrome inherited in an autosomal dominant pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100256"
    }
  ],
  "roots": [
    {
      "id": 6695,
      "label": "gastric carcinoma"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma"
    }
  ]
}