{
  "id": 6780,
  "label": "pancreatic insulin-producing neuroendocrine tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005048",
  "properties": {
    "xrefs": [
      "EFO:0000549",
      "GARD:0003010",
      "ICDO:8151/0",
      "ICDO:8151/1",
      "MEDGEN:1844884",
      "NCIT:C3140",
      "Orphanet:97279",
      "UMLS:C5848150"
    ],
    "synonyms": [
      "Beta cell tumor",
      "Beta cell tumor of pancreas",
      "Beta cell tumor of the pancreas",
      "Beta cell tumour",
      "Beta cell tumour of pancreas",
      "Beta cell tumour of the pancreas",
      "beta cell neoplasm",
      "beta cell tumor of the pancreas",
      "beta cell tumour of the pancreas",
      "insulin-producing islet cell tumor",
      "insulin-producing islet cell tumour",
      "insulin-producing tumor of islet cells",
      "insulin-producing tumor of the islet cells",
      "insulin-producing tumour of islet cells",
      "insulin-producing tumour of the islet cells",
      "pancreatic Beta cell tumor",
      "pancreatic Beta cell tumour",
      "pancreatic insulin producing NET",
      "pancreatic insulin producing neoplasm",
      "pancreatic insulin producing tumor",
      "pancreatic insulin producing tumour",
      "pancreatic insulin-producing neuroendocrine tumor",
      "pancreatic insulin-producing tumor",
      "pancreatic insulin-producing tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. It may or may not be associated with inappropriate secretion of insulin and an associated clinical syndrome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        7431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000045",
          "GARD:0013034",
          "ICDO:8150/1",
          "MEDGEN:277875",
          "NCIT:C27720",
          "ONCOTREE:PANET",
          "Orphanet:97253",
          "UMLS:C1337011"
        ],
        "synonyms": [
          "islet cell tumor",
          "islet cell tumors - pancreas",
          "islet cell tumors of the pancreas",
          "islet cell tumour",
          "islet cell tumours - pancreas",
          "islet cell tumours of the pancreas",
          "pancreatic NET",
          "pancreatic neuroendocrine tumor",
          "well differentiated pancreatic endocrine neoplasm",
          "well differentiated pancreatic endocrine tumor",
          "well differentiated pancreatic endocrine tumour",
          "well-differentiated NEN of pancreas",
          "well-differentiated neuroendocrine neoplasm of pancreas",
          "well-differentiated pancreatic NEN",
          "well-differentiated pancreatic neuroendocrine neoplasm",
          "PANET",
          "neuroendocrine tumor of pancreas",
          "neuroendocrine tumour of pancreas",
          "pancreatic endocrine tumor",
          "pancreatic endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)."
      },
      "child_count": 22,
      "reference_id": "MONDO:0019954"
    }
  ],
  "children": [
    {
      "id": 21578,
      "label": "pancreatic insulinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6780,
        21182
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3892",
          "GARD:0025458",
          "HP:0012197",
          "MEDGEN:43907",
          "MESH:D007340",
          "MedDRA:10022498",
          "NANDO:2200398",
          "NCIT:C95598",
          "SCTID:302822000",
          "UMLS:C0021670",
          "icd11.foundation:193813168"
        ],
        "synonyms": [
          "insulinoma",
          "pancreatic insulinoma",
          "Insulinomas",
          "Insulomas",
          "adenoma, beta cell",
          "adenoma, beta-cell",
          "adenomas, beta-cell",
          "beta cell tumor",
          "beta cell tumour",
          "beta-cell adenoma",
          "beta-cell adenomas",
          "beta-cell tumor",
          "beta-cell tumors",
          "beta-cell tumour",
          "beta-cell tumours",
          "insulin-producing tumour of islet cells",
          "insulinoma tumor suppressor GENE locus",
          "insulinoma tumour suppressor GENE locus",
          "insuloma",
          "islet cell adenoma",
          "tumor, beta-cell",
          "tumors, beta-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024677"
    }
  ],
  "roots": [
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor"
    }
  ]
}