{
  "id": 6786,
  "label": "keratinizing squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005056",
  "properties": {
    "xrefs": [
      "DOID:5521",
      "EFO:0000559",
      "ICDO:8071/3",
      "MEDGEN:137730",
      "NCIT:C4105",
      "UMLS:C0334247"
    ],
    "synonyms": [
      "keratinizing squamous cell carcinoma",
      "squamous cell carcinoma, keratinizing (morphologic abnormality)"
    ],
    "definition": "Squamous cell carcinomas with morphologically prominent production of keratin."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    }
  ],
  "children": [
    {
      "id": 5413,
      "label": "sarcomatoid squamous cell skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5536",
          "MEDGEN:87611",
          "NCIT:C4666",
          "SCTID:254653005",
          "UMLS:C0349656"
        ],
        "synonyms": [
          "spindle cell squamous carcinoma of skin",
          "spindle cell squamous carcinoma of the skin",
          "spindle cell squamous cell carcinoma",
          "spindle cell (sarcomatoid) squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the skin with a prominent spindle cell component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003499"
    },
    {
      "id": 5926,
      "label": "skin basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        5405,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7049",
          "MEDGEN:233446",
          "NCIT:C27543",
          "UMLS:C1335973"
        ],
        "synonyms": [
          "basaloid skin squamous cell carcinoma",
          "skin basaloid carcinoma",
          "skin basaloid squamous cell carcinoma",
          "zone of skin basaloid squamous cell carcinoma",
          "basaloid squamous cell skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A basaloid squamous cell carcinoma that involves the zone of skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004091"
    },
    {
      "id": 6021,
      "label": "vulvar keratinizing squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6786,
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7363",
          "GARD:0023872",
          "MEDGEN:378346",
          "NCIT:C40284",
          "UMLS:C2109334"
        ],
        "synonyms": [
          "vulvar keratinizing squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the vulva and is characterized by the presence of keratin pearls."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004199"
    },
    {
      "id": 6053,
      "label": "large cell keratinizing variant squamous cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6786,
        7640
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7461",
          "GARD:0023890",
          "MEDGEN:274269",
          "NCIT:C40357",
          "UMLS:C1519486"
        ],
        "synonyms": [
          "squamous cell breast carcinoma, large cell keratinizing variant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of large malignant cells that exhibit keratinization."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004232"
    },
    {
      "id": 6060,
      "label": "cervical keratinizing squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6786,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7483",
          "GARD:0023894",
          "MEDGEN:309255",
          "NCIT:C40187",
          "UMLS:C1517658"
        ],
        "synonyms": [
          "cervical keratinizing squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A variant of cervical squamous cell carcinoma characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004239"
    },
    {
      "id": 6132,
      "label": "acantholytic squamous cell skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7643",
          "MEDGEN:91065",
          "NCIT:C4460",
          "SCTID:254654004",
          "UMLS:C0345979"
        ],
        "synonyms": [
          "acantholytic squamous cell carcinoma of the skin",
          "acantholytic squamous cell skin carcinoma",
          "acantholytic squamous cell carcinoma of skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004316"
    },
    {
      "id": 6275,
      "label": "pseudovascular skin squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8122",
          "MEDGEN:233447",
          "NCIT:C27542",
          "UMLS:C1335974"
        ],
        "synonyms": [
          "pseudovascular skin squamous cell carcinoma",
          "skin pseudovascular squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004469"
    },
    {
      "id": 6324,
      "label": "clear cell squamous cell skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8288",
          "MEDGEN:91064",
          "NCIT:C4459",
          "SCTID:254652000",
          "UMLS:C0345978"
        ],
        "synonyms": [
          "clear cell squamous cell carcinoma of skin",
          "clear cell squamous cell carcinoma of the skin",
          "clear cell squamous cell skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the skin with a prominent clear cell component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004523"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    }
  ]
}