{
  "id": 6787,
  "label": "large cell neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005057",
  "properties": {
    "xrefs": [
      "DOID:0050872",
      "EFO:0000563",
      "GARD:0024145",
      "ICDO:8013/3",
      "MEDGEN:220402",
      "NCIT:C6875",
      "ONCOTREE:LUNE",
      "UMLS:C1265996",
      "icd11.foundation:1278312485"
    ],
    "synonyms": [
      "LCNEC",
      "large cell NEC",
      "large cell neuroendocrine carcinoma",
      "large-cell neuroendocrine carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 6943,
      "label": "large cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4552",
          "ICDO:8012/3",
          "MEDGEN:61665",
          "MESH:D018287",
          "NCIT:C3780",
          "UMLS:C0206704"
        ],
        "synonyms": [
          "carcinoma, large cell",
          "large cell carcinoma"
        ],
        "definition": "A malignant epithelial neoplasm composed of large, atypical cells."
      },
      "child_count": 5,
      "reference_id": "MONDO:0005232"
    }
  ],
  "children": [
    {
      "id": 5038,
      "label": "thymic large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6787,
        19965
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4553",
          "GARD:0023344",
          "MEDGEN:235250",
          "NCIT:C6461",
          "UMLS:C1334364"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of Thymus",
          "large cell neuroendocrine carcinoma of the Thymus",
          "large cell neuroendocrine carcinoma of thymus",
          "thymic LCNEC",
          "thymic large cell neuroendocrine carcinoma",
          "thymus large cell carcinoma",
          "thymus large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive, non-small cell, poorly differentiated thymic neuroendocrine carcinoma, characterized by the presence of a high mitotic rate and, almost always, necrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003047"
    },
    {
      "id": 5039,
      "label": "ovarian large-cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4561,
        6787,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4555",
          "GARD:0023345",
          "MEDGEN:233809",
          "NCIT:C5238",
          "UMLS:C1335174"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of ovary",
          "large cell neuroendocrine carcinoma of the ovary",
          "large-cell neuroendocrine carcinoma of ovary",
          "large-cell neuroendocrine carcinoma of the ovary",
          "non-small-cell type neuroendocrine carcinoma of ovary",
          "non-small-cell type neuroendocrine carcinoma of the ovary",
          "ovarian large cell NEC",
          "ovarian large cell neuroendocrine carcinoma",
          "ovarian non-small-cell type neuroendocrine carcinoma",
          "ovary large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the ovary and is characterized by the presence of large malignant cells exhibiting neuroendocrine differentiation. The prognosis is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003049"
    },
    {
      "id": 5817,
      "label": "breast large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4564,
        6787,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6657",
          "GARD:0023753",
          "MEDGEN:307310",
          "NCIT:C40356",
          "UMLS:C1511316"
        ],
        "synonyms": [
          "breast large cell neuroendocrine carcinoma",
          "large cell neuroendocrine carcinoma of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A poorly differentiated neuroendocrine carcinoma that arises from the breast. It is characterized by the presence of large neuroendocrine cells and high mitotic activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003959"
    },
    {
      "id": 5818,
      "label": "pulmonary large cell neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5040,
        6787,
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6658",
          "GARD:0023754",
          "MEDGEN:233608",
          "NCIT:C5672",
          "UMLS:C1334363"
        ],
        "synonyms": [
          "LCNEC of the lung",
          "large cell lung carcinoma with neuroendocrine differentiation",
          "large cell lung neuroendocrine carcinoma",
          "large cell neuroendocrine carcinoma of lung",
          "large cell neuroendocrine carcinoma of the lung",
          "lung large cell neuroendocrine carcinoma",
          "pulmonary large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A large cell neuroendocrine carcinoma that involves the lung(s)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003960"
    },
    {
      "id": 7701,
      "label": "cervical large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6787,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6659",
          "EFO:1000167",
          "GARD:0024306",
          "MEDGEN:275711",
          "NCIT:C40214",
          "ONCOTREE:CENE",
          "UMLS:C1516417"
        ],
        "synonyms": [
          "cervical large cell neuroendocrine carcinoma",
          "cervical neuroendocrine tumor",
          "cervical neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, aggressive neuroendocrine carcinoma that arises from the cervix and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006138"
    },
    {
      "id": 7873,
      "label": "pancreatic large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6787,
        6912,
        7497
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000442",
          "GARD:0024376",
          "MEDGEN:459465",
          "NCIT:C95582",
          "UMLS:C2987239"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of pancreas",
          "pancreas large cell neuroendocrine carcinoma",
          "pancreatic large cell NEC",
          "pancreatic large cell NEC G3",
          "pancreatic large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant large cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006347"
    }
  ],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 6943,
      "label": "large cell carcinoma"
    }
  ]
}