{
  "id": 6788,
  "label": "leiomyosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005058",
  "properties": {
    "xrefs": [
      "DOID:1967",
      "EFO:0000564",
      "GARD:0006880",
      "ICD9:171.9",
      "ICDO:8890/3",
      "MEDGEN:9711",
      "MESH:D007890",
      "MedDRA:10024189",
      "NANDO:2200064",
      "NCIT:C3158",
      "NORD:1356",
      "ONCOTREE:LMS",
      "Orphanet:64720",
      "SCTID:443719001",
      "UMLS:C0023269"
    ],
    "synonyms": [
      "Leiomyosarcomas",
      "leiomyosarcoma",
      "leiomyosarcoma (excluding uterine leiomyosarcoma)",
      "leiomyosarcoma - not uterine",
      "leiomyosarcoma, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 31,
  "parents": [
    {
      "id": 4931,
      "label": "smooth muscle cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7472,
        8400
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4230",
          "NCIT:C6511"
        ],
        "synonyms": [
          "cancer of smooth muscle",
          "cancer of the smooth muscle",
          "malignant neoplasm of smooth muscle",
          "malignant neoplasm of the smooth muscle",
          "malignant smooth muscle neoplasm",
          "malignant smooth muscle tumor",
          "malignant smooth muscle tumour",
          "malignant tumor of the smooth muscle",
          "malignant tumour of smooth muscle",
          "malignant tumour of the smooth muscle"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A malignant neoplasm arising from smooth muscle."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002924"
    },
    {
      "id": 17662,
      "label": "Epstein-Barr virus-associated mesenchymal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021149",
          "MEDGEN:1843096",
          "Orphanet:289656",
          "UMLS:C5679941"
        ],
        "synonyms": [
          "EBV-associated mesenchymal tumor",
          "EBV-associated mesenchymal tumour"
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0017345"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        21548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070663",
          "EFO:1001968",
          "GARD:0004898",
          "MEDGEN:1642116",
          "NCIT:C9306",
          "NORD:1953",
          "Orphanet:3394",
          "SCTID:424952003",
          "UMLS:C4551687"
        ],
        "synonyms": [
          "malignant soft tissue tumor",
          "malignant soft tissue tumour",
          "connective tissue sarcoma",
          "malignant mesenchymal tumor",
          "malignant mesenchymal tumour",
          "non-Rhabdo. soft tissue sarcoma",
          "sarcoma of soft tissue",
          "sarcoma of the soft tissue",
          "soft part sarcoma",
          "soft tissue sarcoma"
        ],
        "definition": "A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones."
      },
      "child_count": 92,
      "reference_id": "MONDO:0018078"
    }
  ],
  "children": [
    {
      "id": 4287,
      "label": "fallopian tube leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4286,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1965",
          "GARD:0023078",
          "MEDGEN:274488",
          "NCIT:C40128",
          "UMLS:C1517116"
        ],
        "synonyms": [
          "fallopian tube leiomyosarcoma",
          "leiomyosarcoma of fallopian tube"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the fallopian tube. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002159"
    },
    {
      "id": 4675,
      "label": "bone leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6788,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3367",
          "GARD:0023193",
          "MEDGEN:234043",
          "NCIT:C7154",
          "UMLS:C1332579"
        ],
        "synonyms": [
          "bone leiomyosarcoma",
          "bone tissue leiomyosarcoma",
          "leiomyosarcoma of bone",
          "leiomyosarcoma of bone tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare aggressive malignant smooth muscle neoplasm, arising from the bone. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002624"
    },
    {
      "id": 5282,
      "label": "inflammatory leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5251",
          "GARD:0023463",
          "MEDGEN:233554",
          "NCIT:C27495",
          "UMLS:C1334179"
        ],
        "synonyms": [
          "inflammatory leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A morphologic variant of leiomyosarcoma characterized by the presence of an inflammatory infiltrate admixed with malignant spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003347"
    },
    {
      "id": 5283,
      "label": "conventional leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5253",
          "GARD:0023464",
          "MEDGEN:232394",
          "NCIT:C9428",
          "UMLS:C1333157"
        ],
        "synonyms": [
          "classic leiomyosarcoma",
          "conventional leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An uncommon, aggressive malignant smooth muscle neoplasm. It is characterized by the presence of atypical large spindle or round cells, nuclear palisading, tumor cell necrosis, mitotic figures and may be associated with vascular invasion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003348"
    },
    {
      "id": 5284,
      "label": "central nervous system leiomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4336,
        6788,
        22971
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5254",
          "GARD:0023465",
          "MEDGEN:235254",
          "NCIT:C6999",
          "UMLS:C1334385"
        ],
        "synonyms": [
          "CNS leiomyosarcoma",
          "central nervous system leiomyosarcoma",
          "leiomyosarcoma of CNS",
          "leiomyosarcoma of central nervous system",
          "leiomyosarcoma of the CNS",
          "leiomyosarcoma of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the central nervous system. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003349"
    },
    {
      "id": 5286,
      "label": "colon leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5287,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5259",
          "GARD:0023467",
          "MEDGEN:232380",
          "NCIT:C5494",
          "UMLS:C1333093",
          "icd11.foundation:1612353121"
        ],
        "synonyms": [
          "colon leiomyosarcoma",
          "colonic leiomyosarcoma",
          "leiomyosarcoma of colon",
          "leiomyosarcoma of the colon"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm that arises from the colon. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003351"
    },
    {
      "id": 5288,
      "label": "heart leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5289,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5261",
          "GARD:0023468",
          "MEDGEN:234095",
          "NCIT:C5364",
          "UMLS:C1332848"
        ],
        "synonyms": [
          "Cardiac leiomyosarcoma",
          "heart leiomyosarcoma",
          "leiomyosarcoma of heart",
          "leiomyosarcoma of the heart"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the heart. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003353"
    },
    {
      "id": 5290,
      "label": "ovary leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4344,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5263",
          "EFO:0006718",
          "GARD:0023470",
          "MEDGEN:233275",
          "NCIT:C5234",
          "UMLS:C1335163"
        ],
        "synonyms": [
          "leiomyosarcoma of ovary",
          "leiomyosarcoma of the ovary",
          "ovarian leiomyosarcoma",
          "ovary leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the ovary. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003355"
    },
    {
      "id": 5291,
      "label": "epithelioid leiomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5264",
          "GARD:0023471",
          "ICDO:8891/3",
          "MEDGEN:61454",
          "NCIT:C3700",
          "UMLS:C0205815"
        ],
        "synonyms": [
          "epithelioid leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A morphologic variant of leiomyosarcoma characterized by the presence of epithelioid round cells with eosinophilic to clear cytoplasm."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003356"
    },
    {
      "id": 5292,
      "label": "lung leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4514,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5265",
          "GARD:0023472",
          "MEDGEN:232711",
          "NCIT:C5667",
          "UMLS:C1334448"
        ],
        "synonyms": [
          "leiomyosarcoma of lung",
          "leiomyosarcoma of the lung",
          "lung leiomyosarcoma",
          "pulmonary leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the lung. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003357"
    },
    {
      "id": 5294,
      "label": "myxoid leiomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5268",
          "GARD:0023474",
          "ICDO:8896/3",
          "MEDGEN:104725",
          "NCIT:C3701",
          "UMLS:C0205816"
        ],
        "synonyms": [
          "myxoid leiomyosarcoma",
          "myxoid leiomyosarcoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A morphologic variant of leiomyosarcoma characterized by the presence of cellular pleomorphism, malignant cells with large nuclei, and a myxoid stroma."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003359"
    },
    {
      "id": 5295,
      "label": "small intestine leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5296,
        6788,
        18539
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5271",
          "GARD:0019852",
          "MEDGEN:183086",
          "NCIT:C7085",
          "Orphanet:104076",
          "SCTID:716651004",
          "UMLS:C0920305",
          "icd11.foundation:389419378"
        ],
        "synonyms": [
          "leiomyosarcoma of small bowel",
          "leiomyosarcoma of small intestine",
          "leiomyosarcoma of the small bowel",
          "leiomyosarcoma of the small intestine",
          "small bowel leiomyosarcoma",
          "small intestinal leiomyosarcoma",
          "small intestine leiomyosarcoma",
          "smooth muscle connective tissue tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the small intestine. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003360"
    },
    {
      "id": 5297,
      "label": "cutaneous leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6788,
        7932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5273",
          "GARD:0023476",
          "HP:0006755",
          "MEDGEN:87534",
          "NCIT:C4484",
          "SCTID:254771006",
          "UMLS:C0346067",
          "icd11.foundation:1653448241"
        ],
        "synonyms": [
          "cutaneous leiomyosarcoma",
          "cutaneous leiomyosarcoma (disease)",
          "leiomyosarcoma of skin",
          "leiomyosarcoma of the skin",
          "leiomyosarcoma of zone of skin",
          "skin leiomyosarcoma",
          "zone of skin leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the skin. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003362"
    },
    {
      "id": 5299,
      "label": "gallbladder leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4871,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5275",
          "GARD:0023478",
          "MEDGEN:234291",
          "NCIT:C5841",
          "UMLS:C1333746"
        ],
        "synonyms": [
          "gall bladder leiomyosarcoma",
          "gallbladder leiomyosarcoma",
          "leiomyosarcoma of gall bladder",
          "leiomyosarcoma of gallbladder",
          "leiomyosarcoma of the gallbladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the gallbladder. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003364"
    },
    {
      "id": 5300,
      "label": "esophagus leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3444,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5276",
          "GARD:0023479",
          "MEDGEN:272589",
          "NCIT:C5334",
          "UMLS:C1333454",
          "icd11.foundation:1419925892"
        ],
        "synonyms": [
          "esophageal leiomyosarcoma",
          "esophagus leiomyosarcoma",
          "leiomyosarcoma of esophagus",
          "leiomyosarcoma of oesophagus",
          "leiomyosarcoma of the esophagus",
          "leiomyosarcoma of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the esophagus. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003365"
    },
    {
      "id": 5302,
      "label": "gastric leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3312,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5280",
          "GARD:0023480",
          "HP:0031025",
          "MEDGEN:196652",
          "NCIT:C27200",
          "SCTID:447785000",
          "UMLS:C0744295",
          "icd11.foundation:399434138"
        ],
        "synonyms": [
          "gastric leiomyosarcoma",
          "gastric leiomyosarcoma (disease)",
          "leiomyosarcoma of stomach",
          "stomach leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the stomach. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003367"
    },
    {
      "id": 5303,
      "label": "prostate leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4868,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5282",
          "GARD:0023481",
          "MEDGEN:233876",
          "NCIT:C5526",
          "UMLS:C1335511"
        ],
        "synonyms": [
          "leiomyosarcoma of prostate",
          "leiomyosarcoma of prostate gland",
          "leiomyosarcoma of the prostate",
          "prostate gland leiomyosarcoma",
          "prostate leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the prostate. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003368"
    },
    {
      "id": 5304,
      "label": "vagina leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4273,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5283",
          "GARD:0023482",
          "MEDGEN:277860",
          "NCIT:C6326",
          "UMLS:C1336940"
        ],
        "synonyms": [
          "leiomyosarcoma of the vagina",
          "leiomyosarcoma of vagina",
          "vagina leiomyosarcoma",
          "vaginal leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the vagina. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003369"
    },
    {
      "id": 5305,
      "label": "retroperitoneal leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3709,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5284",
          "GARD:0023483",
          "MEDGEN:412162",
          "NCIT:C27904",
          "UMLS:C2187547"
        ],
        "synonyms": [
          "leiomyosarcoma of retroperitoneal space",
          "retroperitoneal leiomyosarcoma",
          "retroperitoneal space leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the retroperitoneum. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003370"
    },
    {
      "id": 5306,
      "label": "breast leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4569,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5285",
          "GARD:0023484",
          "MEDGEN:234050",
          "NCIT:C5186",
          "UMLS:C1332631"
        ],
        "synonyms": [
          "breast leiomyosarcoma",
          "leiomyosarcoma of breast",
          "leiomyosarcoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the breast. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003371"
    },
    {
      "id": 5307,
      "label": "vulvar leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6788,
        6930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5286",
          "EFO:1001975",
          "GARD:0023485",
          "MEDGEN:378348",
          "NCIT:C40318",
          "UMLS:C2168304"
        ],
        "synonyms": [
          "leiomyosarcoma of mammalian vulva",
          "mammalian vulva leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the vulva. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003372"
    },
    {
      "id": 5308,
      "label": "kidney leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4936,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5287",
          "GARD:0023486",
          "MEDGEN:235545",
          "NCIT:C6183",
          "UMLS:C1335743"
        ],
        "synonyms": [
          "kidney leiomyosarcoma",
          "leiomyosarcoma of kidney",
          "leiomyosarcoma of the kidney",
          "renal leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the kidney. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003373"
    },
    {
      "id": 5309,
      "label": "laryngeal leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4531,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5288",
          "GARD:0023487",
          "MEDGEN:272791",
          "NCIT:C6022",
          "UMLS:C1334371"
        ],
        "synonyms": [
          "laryngeal leiomyosarcoma",
          "larynx leiomyosarcoma",
          "leiomyosarcoma of larynx",
          "leiomyosarcoma of the larynx"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the larynx. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003374"
    },
    {
      "id": 5310,
      "label": "mediastinum leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4866,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5292",
          "GARD:0023488",
          "MEDGEN:235310",
          "NCIT:C6619",
          "UMLS:C1334660"
        ],
        "synonyms": [
          "leiomyosarcoma of mediastinum",
          "leiomyosarcoma of the mediastinum",
          "mediastinal leiomyosarcoma",
          "mediastinum leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the mediastinum. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003376"
    },
    {
      "id": 5312,
      "label": "liver leiomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4487,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5296",
          "GARD:0023490",
          "MEDGEN:272707",
          "NCIT:C5756",
          "UMLS:C1333969"
        ],
        "synonyms": [
          "hepatic leiomyosarcoma",
          "leiomyosarcoma of liver",
          "leiomyosarcoma of the liver",
          "liver leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the liver. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003378"
    },
    {
      "id": 5313,
      "label": "rectum leiomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4294,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5297",
          "GARD:0023491",
          "MEDGEN:233391",
          "NCIT:C5549",
          "UMLS:C1335683",
          "icd11.foundation:905391296"
        ],
        "synonyms": [
          "leiomyosarcoma of rectum",
          "leiomyosarcoma of the rectum",
          "rectal leiomyosarcoma",
          "rectum leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm that arises from the rectum. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003379"
    },
    {
      "id": 6028,
      "label": "pulmonary vein leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6420,
        6788,
        17394,
        23003
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7388",
          "GARD:0023875",
          "MEDGEN:235513",
          "NCIT:C5374",
          "UMLS:C1335575"
        ],
        "synonyms": [
          "leiomyosarcoma of pulmonary vein",
          "leiomyosarcoma of the pulmonary vein",
          "pulmonary vein leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the pulmonary vein. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004206"
    },
    {
      "id": 6029,
      "label": "pulmonary artery leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2933,
        6788,
        17394,
        23003
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7389",
          "GARD:0023876",
          "MEDGEN:233372",
          "NCIT:C5373",
          "UMLS:C1335572"
        ],
        "synonyms": [
          "leiomyosarcoma of pulmonary artery",
          "leiomyosarcoma of the pulmonary artery",
          "pulmonary artery leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the pulmonary artery It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004207"
    },
    {
      "id": 6030,
      "label": "superior vena cava leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5025,
        6788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7390",
          "GARD:0023877",
          "MEDGEN:236963",
          "NCIT:C6745",
          "UMLS:C1336531"
        ],
        "synonyms": [
          "anterior vena cava leiomyosarcoma",
          "leiomyosarcoma of Superior vena cava",
          "leiomyosarcoma of anterior vena cava",
          "leiomyosarcoma of the Superior vena cava"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the superior vena cava. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004208"
    },
    {
      "id": 16826,
      "label": "leiomyosarcoma of the corpus uteri",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6327,
        6788,
        6926
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5289",
          "EFO:1001974",
          "GARD:0020477",
          "MEDGEN:83679",
          "NCIT:C6340",
          "NORD:1817",
          "ONCOTREE:ULMS",
          "Orphanet:213625",
          "SCTID:447389009",
          "UMLS:C0280631"
        ],
        "synonyms": [
          "Uterine Leiomyosarcoma",
          "body of uterus leiomyosarcoma",
          "corpus uteri leiomyosarcoma",
          "leiomyosarcoma - uterus",
          "leiomyosarcoma of body of uterus",
          "leiomyosarcoma of corpus uteri",
          "leiomyosarcoma of the body of uterus",
          "leiomyosarcoma of the corpus uteri",
          "leiomyosarcoma of the uterine body",
          "leiomyosarcoma of the uterine corpus",
          "leiomyosarcoma of the uterus",
          "leiomyosarcoma of uterine body",
          "leiomyosarcoma of uterine corpus",
          "leiomyosarcoma of uterus",
          "uterine body leiomyosarcoma",
          "uterine corpus leiomyosarcoma",
          "uterine leiomyosarcoma",
          "uterus leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from the uterine corpus. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016262"
    },
    {
      "id": 16842,
      "label": "leiomyosarcoma of the cervix uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6788,
        16839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020495",
          "MEDGEN:927349",
          "NCIT:C128047",
          "ONCOTREE:CELI",
          "Orphanet:213807",
          "SCTID:763771009",
          "UMLS:C4289817"
        ],
        "synonyms": [
          "cervical leiomyosarcoma",
          "leiomyosarcoma of uterine cervix",
          "uterine cervix leiomyosarcoma",
          "CELI"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Leiomyosarcoma of the cervix uteri is a rare, malignant mesenchymal tumor of smooth muscle origin, macroscopically appearing as a large, poorly circumscribed mass, often protruding from the cervical canal or expanding it circumferentially. The most common presenting symptoms are vaginal discharge or bleeding, pain in the lower abdomen and a bulky cervical mass. There is a reported tendency to metastatsize hematogenously, especially to the lungs, peritoneum, bones and the liver."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016283"
    }
  ],
  "roots": [
    {
      "id": 4931,
      "label": "smooth muscle cancer"
    },
    {
      "id": 17662,
      "label": "Epstein-Barr virus-associated mesenchymal tumor"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma"
    }
  ]
}